Yellow fever virus - Revision history

Aidan: /* Prevention */

2020-09-17T00:38:00Z

Prevention

← Older revision		Revision as of 00:38, 17 September 2020
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	*RNA virus and member of the [[Flaviviridae]] family		*RNA virus and member of the [[Flaviviridae]] family

	=== Epidemiology ===		===Epidemiology===

	* Worldwide, about 200,000 cases and 30,000 deaths annually		*Worldwide, about 200,000 cases and 30,000 deaths annually

	== Clinical Manifestations ==		==Clinical Manifestations==

	* Spectrum of illness from asymptomatic to fatal		*Spectrum of illness from asymptomatic to fatal
	* Acute illness starts with fever, chills, headache, backache, myalgias, arthralgias, nausea, vomiting, photophobia, mild jaundice, and epigastric pain		*Acute illness starts with fever, chills, headache, backache, myalgias, arthralgias, nausea, vomiting, photophobia, mild jaundice, and epigastric pain
	* After the acute illness subsides, about 85% of infections are resolved, and 15% progress		*After the acute illness subsides, about 85% of infections are resolved, and 15% progress
	* In those who progress, a brief remission of hours to days is followed by return of symptoms with progression to renal failure, hemorrhage, and thrombocytopenia		*In those who progress, a brief remission of hours to days is followed by return of symptoms with progression to renal failure, hemorrhage, and thrombocytopenia

	=== Vaccine-Related Disease ===		===Vaccine-Related Disease===

	* [[Yellow fever vaccine-associated neurotropic disease]], which includes [[meningoencephalitis]], [[Guillain-Barré syndrome]], and acute bulbar palsy		*[[Yellow fever vaccine-associated neurotropic disease]], which includes [[meningoencephalitis]], [[Guillain-Barré syndrome]], and acute bulbar palsy
	* [[Yellow fever vaccine-associated viscerotropic disease]], which causes multi-organ failure similar to wildtype virus		*[[Yellow fever vaccine-associated viscerotropic disease]], which causes multi-organ failure similar to wildtype virus

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	== Management ==		==Management==

	* Supportive care		*Supportive care

	==Prevention==		==Prevention==

	*A live attenuated vaccine strain is available		*A live attenuated vaccine strain is available, with a single dose provided at least decades of and possibly life-long immunity
			*Antibodies develop within 28 days
	*Contraindications		*Contraindications
	**Allergy to any component of the vaccine		**Allergy to any component of the vaccine
			**Immunocompromised state, including HIV with CD4 <200 or <15%, B-cell deficiency (except isolated [[IgA deficiency]], [[IgG subclass deficiency]], and [[specific antibody deficiency]]), and combined B- and T-cell deficiency
	**Infants less than 6 to 9 months of age, due to the high risk of [[Yellow fever vaccine-associated neurotropic disease\|neurotropic disease]] following immunization		**Infants less than 6 to 9 months of age, due to the high risk of [[Yellow fever vaccine-associated neurotropic disease\|neurotropic disease]] following immunization
	**People age 60 years and older, due to the high risk of adverse events following immunization		**People age 60 years and older, due to the high risk of adverse events following immunization
	***Booster doses may stll be given, if indicated		***Booster doses may stll be given, if indicated
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	**Thymus disease, including [[thymoma]], [[thymectomy]], and [[myasthenia gravis]], given the high risk of [[Yellow fever vaccine-associated viscerotropic disease\|viscerotropic disease]]		**Thymus disease, including [[thymoma]], [[thymectomy]], and [[myasthenia gravis]], given the high risk of [[Yellow fever vaccine-associated viscerotropic disease\|viscerotropic disease]]
	**Moderate or severe acute illness		**Moderate or severe acute illness
			*Booster doses
			**No longer routinely indicated
			**May be indicated if the original dose was given when the recipient was unlikely to mount a full immune response
			***Vaccinated during pregnancy, while on immunosuppressants, or other immunocompromise like HIV
			****One-time booster for most, and booster every 10 years for HIV
			***Hematopoietic stem cell transplant since last vaccination
			****One-time full dose
			***Last dose was fractional, given improperly, undocumented, or underdocumented
			****One-time full dose
			**May be indicated for individuals at particularly high risk of exposure
			***Travel to an area experiencing an outbreak
			***Frequent or prolonged travel to areas with high endemicity, particularly West Africa
			***One-time booster if 10 or more years since primary vaccination
			**May be indicated for individuals with regular and ongoing exposure
			***Laboratory workers working on yellow fever virus
			***Booster every 10 years unless antibody titres confirm ongoing immunity
	*Vaccination can cause [[Yellow fever vaccine-associated neurotropic disease\|YF vaccine-associated neurotropic disease]] and [[Yellow fever vaccine-associated viscerotropic disease\|YF vaccine-associated viscerotropic disease]]		*Vaccination can cause [[Yellow fever vaccine-associated neurotropic disease\|YF vaccine-associated neurotropic disease]] and [[Yellow fever vaccine-associated viscerotropic disease\|YF vaccine-associated viscerotropic disease]]

Aidan at 00:24, 17 September 2020

2020-09-17T00:24:17Z

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Microbiology ===
+===Microbiology===
-* RNA virus and member of the [[Flaviviridae]] family
+*RNA virus and member of the [[Flaviviridae]] family
-== Prevention ==
+=== Epidemiology ===
 [[Category:Flaviviridae]]

Aidan at 12:42, 14 August 2020

2020-08-14T12:42:31Z

← Older revision		Revision as of 12:42, 14 August 2020
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	* Vaccination can cause [[Yellow fever vaccine-associated neurotropic disease\|YF vaccine-associated neurotropic disease]] and [[Yellow fever vaccine-associated viscerotropic disease\|YF vaccine-associated viscerotropic disease]], primarily in older people		* Vaccination can cause [[Yellow fever vaccine-associated neurotropic disease\|YF vaccine-associated neurotropic disease]] and [[Yellow fever vaccine-associated viscerotropic disease\|YF vaccine-associated viscerotropic disease]], primarily in older people

	[[Category:~~RNA viruses~~]]		[[Category:Flaviviridae]]
	[[Category:Infectious diseases]]		[[Category:Infectious diseases]]

Aidan: Created page with "== Background == === Microbiology === * RNA virus and member of the Flaviviridae family == Prevention == * Vaccination can cause Yellow fever vaccine-associated neur..."

2020-08-10T20:57:01Z

Created page with "== Background == === Microbiology === * RNA virus and member of the Flaviviridae family == Prevention == * Vaccination can cause Yellow fever vaccine-associated neur..."

New page

== Background ==

=== Microbiology ===

* RNA virus and member of the [[Flaviviridae]] family

== Prevention ==

* Vaccination can cause [[Yellow fever vaccine-associated neurotropic disease|YF vaccine-associated neurotropic disease]] and [[Yellow fever vaccine-associated viscerotropic disease|YF vaccine-associated viscerotropic disease]], primarily in older people

[[Category:RNA viruses]]
[[Category:Infectious diseases]]