https://idwiki.org/index.php?action=history&feed=atom&title=Wolfram_syndrome 2026-05-13T00:00:59Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Wolfram_syndrome&diff=5441&oldid=prev 2020-08-02T12:23:43Z

<p>Text replacement - &quot;== Clinical Presentation&quot; to &quot;== Clinical Manifestations&quot;</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:23, 2 August 2020</td> </tr><tr> <td colspan="2" class="diff-lineno">Line 26:</td> <td colspan="2" class="diff-lineno">Line 26:</td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>** 1/150 cases of T1DM are Wolfram syndrome</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>** 1/150 cases of T1DM are Wolfram syndrome</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <del style="font-weight: bold; text-decoration: none;">Presentation</del> ==</div></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <ins style="font-weight: bold; text-decoration: none;">Manifestations</ins> ==</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Diabetes mellitus presents in childhood</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Diabetes mellitus presents in childhood</div></td> </tr> <!-- diff cache key site7_mediawiki:diff:1.41:old-4530:rev-5441:wikidiff2=table:1.13.0:bc2a06be --> </table>

Aidan https://idwiki.org/index.php?title=Wolfram_syndrome&diff=4530&oldid=prev 2020-07-04T01:18:02Z

<p>Imported from text file</p> <p><b>New page</b></p><div>== Definition ==<br /> <br /> * Congenital syndrome characterized by diabetes mellitus and optic atrophy, along with other associated issues<br /> * Also known as DIDMOAD<br /> ** Diabetes insipidus (central)<br /> ** Diabetes mellitus (non-autoimmune type 1)<br /> ** Optic atrophy<br /> ** Deafness<br /> * There is also Type 2 Wolfram syndrome<br /> ** GI ulcers with resulting bleeds<br /> ** No DI<br /> <br /> == Pathophysiology ==<br /> <br /> * WFS1 mutation (encodes Wolframin protein)<br /> * Transmembrane protein present in many systems<br /> ** Pancreas, brain, spinal cord, heart, muscle &amp;gt;&amp;gt; liver, kidneys<br /> * Putative functions include membrane trafficking, secreation, processing, and regulation of ER calcium homeostasis<br /> <br /> == Epidemiology ==<br /> <br /> * Prevalence 1/750,000; highest in Lebanese (1/68,000)<br /> * DM<br /> ** Insulin-dependent, T1DM-style from destruction of pancreatic cell<br /> ** Presents in childhood<br /> ** 1/150 cases of T1DM are Wolfram syndrome<br /> <br /> == Clinical Presentation ==<br /> <br /> * Diabetes mellitus presents in childhood<br /> * Diabetes insipidus is central and presents in teenage years or early adulthood<br /> * Hypogonadism M&amp;gt;F<br /> * Hypothalamic pituitarism: GH deficiency, cotricotropin deficiency<br /> <br /> [[Category:Endocrinology]]<br /> [[Category:Pediatrics]]</div>

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