Wernicke encephalopathy - Revision history

Aidan at 14:44, 16 October 2020

2020-10-16T14:44:43Z

← Older revision		Revision as of 14:44, 16 October 2020
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	== ~~Definition~~ ==		==Background==

	* Syndrome of cerebellar ataxia, ophthalmoplegia (usually bilateral CN VI palsies), and global confusion caused by vitamin B1 deficiency		*Syndrome of cerebellar ataxia, ophthalmoplegia (usually bilateral CN VI palsies), and global confusion caused by vitamin B1 deficiency, usually in the context of chronic alcohol use, and often in the context of a combined [[Wernicke-Korsakoff syndrome]]
	** Often has horizontal nystagmus
⚫	* When there is additional amnesia, with or without confabulation, the syndrome is known as '''Wernicke-Korsakoff''' syndrome

			===Pathophysiology===
	== Etiology ==

	* Thiamine (vitamin B1) deficiency, often associated with chronic alcohol abuse		*Thiamine (vitamin B1) deficiency, often associated with chronic alcohol abuse

		⚫	==Clinical Manifestations==
⚫	== Differential Diagnosis ==

			*Only a third present with the classic triad of [[cerebellar ataxia]], [[ophthalmoplegia]] (usually bilateral CN VI palsies), and global confusion
⚫	* Alcohol ~~abuse~~ is most common
		⚫	*Most are disoriented and inattentive
⚫	* Other causes of malnutrition, including hyperemesis, starvation, dialysis, cancer, HIV/AIDS, or rarely gastric surgery
		⚫	*Ophthalmoplegia
		⚫	**Horizontal nystagmus
		⚫	**Lateral rectus (CN VI) palsy (usually bilateral)
		⚫	**Conjugate gaze palsies
		⚫	**Ptosis
		⚫	*[[Gait ataxia]]
		⚫	*Spares pupils unless severe
		⚫	*When there is additional [[amnesia]], with or without [[confabulation]], the syndrome is known as '''Wernicke-Korsakoff''' syndrome

		⚫	==Differential Diagnosis==
⚫	== Clinical Manifestations ==

		⚫	*[[Alcohol use disorder]] is most common
	* Only a third present with the classic triad
		⚫	*Other causes of [[malnutrition]], including [[hyperemesis]], [[starvation]], [[dialysis]], [[cancer]], [[HIV\|HIV/AIDS]], or rarely gastric surgery
⚫	* Most are disoriented and inattentive
⚫	* Ophthalmoplegia
⚫	** Horizontal nystagmus
⚫	** Lateral rectus (CN VI) palsy (usually bilateral)
⚫	** Conjugate gaze palsies
⚫	** Ptosis
⚫	* Gait ataxia
⚫	* Spares pupils unless severe

	== Management ==		==Management==

	* Thamine 200-500mg IV/IM TID x3 days		*[[Thamine]] 200 to 500mg IV/IM TID x3 days

	== Prognosis ==		==Prognosis==

	* Often leads to Korsakoff syndrome		*Often leads to Korsakoff syndrome

	[[Category:Neurology]]		[[Category:Neurology]]

Aidan: Text replacement - "== Clinical Presentation" to "== Clinical Manifestations"

2020-08-02T13:55:03Z

Text replacement - "== Clinical Presentation" to "== Clinical Manifestations"

← Older revision		Revision as of 13:55, 2 August 2020
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	* Other causes of malnutrition, including hyperemesis, starvation, dialysis, cancer, HIV/AIDS, or rarely gastric surgery		* Other causes of malnutrition, including hyperemesis, starvation, dialysis, cancer, HIV/AIDS, or rarely gastric surgery

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==

	* Only a third present with the classic triad		* Only a third present with the classic triad

Maintenance script: Imported from text file

2020-07-04T01:18:02Z

Imported from text file

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== Definition ==

* Syndrome of cerebellar ataxia, ophthalmoplegia (usually bilateral CN VI palsies), and global confusion caused by vitamin B1 deficiency
** Often has horizontal nystagmus
* When there is additional amnesia, with or without confabulation, the syndrome is known as '''Wernicke-Korsakoff''' syndrome

== Etiology ==

* Thiamine (vitamin B1) deficiency, often associated with chronic alcohol abuse

== Differential Diagnosis ==

* Alcohol abuse is most common
* Other causes of malnutrition, including hyperemesis, starvation, dialysis, cancer, HIV/AIDS, or rarely gastric surgery

== Clinical Presentation ==

* Only a third present with the classic triad
* Most are disoriented and inattentive
* Ophthalmoplegia
** Horizontal nystagmus
** Lateral rectus (CN VI) palsy (usually bilateral)
** Conjugate gaze palsies
** Ptosis
* Gait ataxia
* Spares pupils unless severe

== Management ==

* Thamine 200-500mg IV/IM TID x3 days

== Prognosis ==

* Often leads to Korsakoff syndrome

[[Category:Neurology]]
[[Category:Gastroenterology]]