Vibrio vulnificus - Revision history

Aidan: /* Clinical Presentation */

2022-09-27T16:13:02Z

Clinical Presentation

← Older revision		Revision as of 16:13, 27 September 2022
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	*Presents as [[Causes::gastroenteritis]], skin infection, and [[Causes::bacteremia]] in an immunocompromised patient (usually cirrhosis)		*Presents as [[Causes::gastroenteritis]], skin infection, and [[Causes::bacteremia]] in an immunocompromised patient (usually cirrhosis)
	*1 to 3 days following ingestion of ~~ulcers~~		*1 to 3 days following ingestion of oysters
	*Severe, rapidly-progressing soft tissue infection		*Severe, rapidly-progressing soft tissue infection
	**Erythematous lesions that develop into [[Causes::hemorrhagic bullae]] then necrotic ulcers		**Erythematous lesions that develop into [[Causes::hemorrhagic bullae]] then necrotic ulcers

Aidan: /* Management */

2020-09-16T23:13:37Z

Management

← Older revision		Revision as of 23:13, 16 September 2020
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	*Needs antibiotics, ideally early, as well as surgical debridement of the nectrotizing soft tissue infection		*Needs antibiotics, ideally early, as well as surgical debridement of the nectrotizing soft tissue infection
	*Fluoroquinolones, third-~~gen~~ cephalosporins, and doxycycline all work		*[[Fluoroquinolones]], third-generation [[cephalosporins]], and [[doxycycline]] all work
			*Should typically start with combination of third-generation [[Cephalosporins\|cephalosporin]] and either [[ciprofloxacin]] or [[doxycycline]]

	==Prevention==		==Prevention==

Aidan: /* Clinical Presentation */

2020-08-24T12:08:09Z

Clinical Presentation

← Older revision		Revision as of 12:08, 24 August 2020
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	* Halophilic (salt-loving) marine pleomorphic Gram-negative rod that causes severe rapidly-progressing soft tissue infections		*Halophilic (salt-loving) marine pleomorphic Gram-negative rod that causes severe rapidly-progressing soft tissue infections

	==Background==		==Background==
	===Pathophysiology===		===Pathophysiology===

	* Polysaccharide capsule is resistant to phagocytosis and triggers cytokine release including TNF-alpha		*Polysaccharide capsule is resistant to phagocytosis and triggers cytokine release including TNF-alpha
	* It can sequester iron from hemoglobin and highly-saturated transferrin		*It can sequester iron from hemoglobin and highly-saturated transferrin

	===Epidemiology===		===Epidemiology===

	* Mostly found in saltwater estuaries, associated with springtime plankton blooms		*Mostly found in saltwater estuaries, associated with springtime plankton blooms
	* Normal microbiotia of molluscs, including oysters and crabs		*Normal microbiotia of molluscs, including oysters and crabs

	===Risk Factors===		===Risk Factors===

	* Cirrhosis		*[[Cirrhosis]]
	* Other liver disease		*Other liver disease
	* Iron-overload states including hemochromatosis, hemolytic anemia, chronic renal failure		*Iron-overload states including [[hemochromatosis]], [[hemolytic anemia]], [[chronic renal failure]]
	* Malignancy		*[[Malignancy]]
	* HIV		*[[HIV]]
	* Immunosuppressing medications		*Immunosuppressing medications

	==Clinical Presentation==		==Clinical Presentation==

	* Presents as ~~sepsis and~~ skin infection in an immunocompromised patient (usually cirrhosis) ~~1 to 3 days following ingestion of ulcers~~		*Presents as [[Causes::gastroenteritis]], skin infection, and [[Causes::bacteremia]] in an immunocompromised patient (usually cirrhosis)
⚫	* Severe, rapidly-progressing soft tissue infection
			*1 to 3 days following ingestion of ulcers
⚫	** Erythematous lesions that develop into hemorrhagic bullae then necrotic ulcers
		⚫	*Severe, rapidly-progressing soft tissue infection
⚫	** Metastatic cutaneous lesions develop at 36 hours
		⚫	**Erythematous lesions that develop into [[Causes::hemorrhagic bullae]] then necrotic ulcers
⚫	** Often related to a wound contaminated with salt water, often in the Golf Coast
		⚫	**Metastatic cutaneous lesions develop at 36 hours
⚫	* Bacteremia is common
		⚫	**Often related to a wound contaminated with salt water, often in the Golf Coast
⚫	** Associated with oyster consumption in 90% of cases
		⚫	*Bacteremia is common
⚫	* 25% case-fatality rate, up to 50% in cases of bacteremia
		⚫	**Associated with oyster consumption in 90% of cases
		⚫	*25% case-fatality rate, up to 50% in cases of bacteremia

	==Management==		==Management==

	* Needs antibiotics, ideally early, as well as surgical debridement of the nectrotizing soft tissue infection		*Needs antibiotics, ideally early, as well as surgical debridement of the nectrotizing soft tissue infection
	* Fluoroquinolones, third-gen cephalosporins, and doxycycline all work		*Fluoroquinolones, third-gen cephalosporins, and doxycycline all work

	==Prevention==		==Prevention==

	* Patients with cirrhosis should avoid eating raw oysters		*Patients with cirrhosis should avoid eating raw oysters

	{{DISPLAYTITLE:''Vibrio vulnificus''}}		{{DISPLAYTITLE:''Vibrio vulnificus''}}

Aidan at 02:16, 17 June 2020

2020-06-17T02:16:10Z

← Older revision		Revision as of 02:16, 17 June 2020
Line 1:		Line 1:
	* Halophilic (salt-loving) marine pleomorphic Gram-negative rod that causes severe rapidly-progressing soft tissue infections		* Halophilic (salt-loving) marine pleomorphic Gram-negative rod that causes severe rapidly-progressing soft tissue infections

			==Background==
	== Pathophysiology ==		===Pathophysiology===

	* Polysaccharide capsule is resistant to phagocytosis and triggers cytokine release including TNF-alpha		* Polysaccharide capsule is resistant to phagocytosis and triggers cytokine release including TNF-alpha
	* It can sequester iron from hemoglobin and highly-saturated transferrin		* It can sequester iron from hemoglobin and highly-saturated transferrin

	== Epidemiology ==		===Epidemiology===

	* Mostly found in saltwater estuaries, associated with springtime plankton blooms		* Mostly found in saltwater estuaries, associated with springtime plankton blooms
	* Normal microbiotia of molluscs, including oysters and crabs		* Normal microbiotia of molluscs, including oysters and crabs

	== Risk Factors ==		===Risk Factors===

	* Cirrhosis		* Cirrhosis
	* Other liver disease		* Other liver disease
Line 20:		Line 18:
	* Immunosuppressing medications		* Immunosuppressing medications

	== Presentation ==		==Clinical Presentation==

	* Presents as sepsis and skin infection in an immunocompromised patient (usually cirrhosis) 1 to 3 days following ingestion of ulcers		* Presents as sepsis and skin infection in an immunocompromised patient (usually cirrhosis) 1 to 3 days following ingestion of ulcers
	* Severe, rapidly-progressing soft tissue infection		* Severe, rapidly-progressing soft tissue infection
Line 31:		Line 28:
	* 25% case-fatality rate, up to 50% in cases of bacteremia		* 25% case-fatality rate, up to 50% in cases of bacteremia

	== Management ==		==Management==

	* Needs antibiotics, ideally early, as well as surgical debridement of the nectrotizing soft tissue infection		* Needs antibiotics, ideally early, as well as surgical debridement of the nectrotizing soft tissue infection
	* Fluoroquinolones, third-gen cephalosporins, and doxycycline all work		* Fluoroquinolones, third-gen cephalosporins, and doxycycline all work

	== Prevention ==		==Prevention==

	* Patients with cirrhosis should avoid eating raw oysters		* Patients with cirrhosis should avoid eating raw oysters

	{{DISPLAYTITLE:''Vibrio ~~vulnificans~~''}}		{{DISPLAYTITLE:''Vibrio vulnificus''}}
	[[Category:Gram-negative bacilli]]		[[Category:Gram-negative bacilli]]

Aidan: Aidan moved page Vibrio vulnificans to Vibrio vulnificus without leaving a redirect: oops

2020-06-17T02:15:09Z

Aidan moved page Vibrio vulnificans to Vibrio vulnificus without leaving a redirect: oops

← Older revision		Revision as of 02:15, 17 June 2020
(No difference)

Aidan at 12:04, 16 August 2019

2019-08-16T12:04:43Z

← Older revision		Revision as of 12:04, 16 August 2019
Line 40:		Line 40:
	* Patients with cirrhosis should avoid eating raw oysters		* Patients with cirrhosis should avoid eating raw oysters

			{{DISPLAYTITLE:''Vibrio vulnificans''}}
	[[Category:Gram-negative bacilli]]		[[Category:Gram-negative bacilli]]

Aidan: Created page with "* Halophilic (salt-loving) marine pleomorphic Gram-negative rod that causes severe rapidly-progressing soft tissue infections == Pathophysiology == * Polysaccharide capsule..."

2019-08-16T12:04:27Z

Created page with "* Halophilic (salt-loving) marine pleomorphic Gram-negative rod that causes severe rapidly-progressing soft tissue infections == Pathophysiology == * Polysaccharide capsule..."

New page

* Halophilic (salt-loving) marine pleomorphic Gram-negative rod that causes severe rapidly-progressing soft tissue infections

== Pathophysiology ==

* Polysaccharide capsule is resistant to phagocytosis and triggers cytokine release including TNF-alpha
* It can sequester iron from hemoglobin and highly-saturated transferrin

== Epidemiology ==

* Mostly found in saltwater estuaries, associated with springtime plankton blooms
* Normal microbiotia of molluscs, including oysters and crabs

== Risk Factors ==

* Cirrhosis
* Other liver disease
* Iron-overload states including hemochromatosis, hemolytic anemia, chronic renal failure
* Malignancy
* HIV
* Immunosuppressing medications

== Presentation ==

* Presents as sepsis and skin infection in an immunocompromised patient (usually cirrhosis) 1 to 3 days following ingestion of ulcers
* Severe, rapidly-progressing soft tissue infection
** Erythematous lesions that develop into hemorrhagic bullae then necrotic ulcers
** Metastatic cutaneous lesions develop at 36 hours
** Often related to a wound contaminated with salt water, often in the Golf Coast
* Bacteremia is common
** Associated with oyster consumption in 90% of cases
* 25% case-fatality rate, up to 50% in cases of bacteremia

== Management ==

* Needs antibiotics, ideally early, as well as surgical debridement of the nectrotizing soft tissue infection
* Fluoroquinolones, third-gen cephalosporins, and doxycycline all work

== Prevention ==

* Patients with cirrhosis should avoid eating raw oysters

[[Category:Gram-negative bacilli]]