Tumour necrosis factor-α inhibitors - Revision history

Aidan at 00:40, 17 March 2022

2022-03-17T00:40:31Z

← Older revision		Revision as of 00:40, 17 March 2022
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	* Baseline [[TST]], ±CXR, prior to starting medications, with patients identified as having [[LTBI]] being offered prophylaxis		* Baseline [[TST]], ±CXR, prior to starting medications, with patients identified as having [[LTBI]] being offered prophylaxis
	** Cutoff for TST is 5 mm		** Cutoff for TST is 5 mm
			*Assess for [[hepatitis B prophylaxis]]

	=== Adverse Effects ===		=== Adverse Effects ===
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	* Bacteria: [[septic arthritis]], [[Listeria monocytogenes]], [[Legionella]], [[Nocardia]], [[Actinomyces]], [[Salmonella]]		* Bacteria: [[septic arthritis]], [[Listeria monocytogenes]], [[Legionella]], [[Nocardia]], [[Actinomyces]], [[Salmonella]]
	* Mycobacteria: [[Mycobacterium tuberculosis\|'''Mycobacterium tuberculosis''']], [[Mycobacterium avium]], [[Mycobacterium bovis]], BCG		* Mycobacteria: [[Mycobacterium tuberculosis\|'''Mycobacterium tuberculosis''']], [[Mycobacterium avium]], [[Mycobacterium bovis]], BCG
			**Risk of TB is higher for [[infliximab]] and [[adalimumab]] compared to [[etanercept]]
	* Fungi: [[Aspergillus fumigatus]], [[Histoplasma capsulatum]], [[Coccidioides]], [[Cryptococcus neoformans]], [[Candida albicans]]		* Fungi: [[Aspergillus fumigatus]], [[Histoplasma capsulatum\|'''Histoplasma capsulatum''']], [[Coccidioides]], [[Cryptococcus neoformans]], [[Candida albicans]]
	* Parasites: [[Toxoplasma gondii]]		* Parasites: [[Toxoplasma gondii]]
	* Viruses: [[hepatitis B virus]], [[hepatitis C virus]], [[varicella-zoster virus]]		* Viruses: [[hepatitis B virus\|'''hepatitis B virus''']], [[hepatitis C virus]], [[varicella-zoster virus]]
	* Screening prior to use should be done for [[LTBI]] (TST or IGRA), [[hepatitis B]], [[hepatitis C]], and [[HIV]]		* Screening prior to use should be done for [[LTBI]] (TST or IGRA), [[hepatitis B]], [[hepatitis C]], and [[HIV]]

Aidan at 00:36, 17 March 2022

2022-03-17T00:36:58Z

← Older revision		Revision as of 00:36, 17 March 2022
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			== Background ==

			* TNF-α is a cytokine involved in the inflammatory response to infection
			* Has soluble and transmembrane forms
			* Produced by macrophages, NK cells, granulocytes, fibroblasts, and T cells
			* Receptors for TNF-α (TNFR1 and TNFR2) are found on most human cells, and are involved in cell activation and proliferation, cytokine production, and granuloma formation

			== Medications ==

			* [[Adalimumab]]
			* [[Infliximab]]
			* [[Certolizumab pegol]]
			* [[Etanercept]]

	== Contraindications ==		== Contraindications ==

	* Active bacterial infection, active tuberculosis or untreated LTBI, active herpes zoster infection, active invasive fungal infection, infected skin ulcers, acute hepatitis B or C, untreated chronic hepatitis B, or chronic hepatitis B or C with Child-Pugh B or C		* Active bacterial infection, active tuberculosis or untreated LTBI, active herpes zoster infection, active invasive fungal infection, infected skin ulcers, acute hepatitis B or C, untreated chronic hepatitis B, or chronic hepatitis B or C with Child-Pugh B or C

	== ~~Infections~~ ==		== Safety ==

			* Baseline [[TST]], ±CXR, prior to starting medications, with patients identified as having [[LTBI]] being offered prophylaxis
			** Cutoff for TST is 5 mm

			=== Adverse Effects ===

			==== Infections ====

	* Bacteria: [[septic arthritis]], [[Listeria monocytogenes]], [[Legionella]], [[Nocardia]], [[Actinomyces]], [[Salmonella]]		* Bacteria: [[septic arthritis]], [[Listeria monocytogenes]], [[Legionella]], [[Nocardia]], [[Actinomyces]], [[Salmonella]]
	* Mycobacteria: [[Mycobacterium tuberculosis]], [[Mycobacterium avium]], [[Mycobacterium bovis]], BCG		* Mycobacteria: [[Mycobacterium tuberculosis\|'''Mycobacterium tuberculosis''']], [[Mycobacterium avium]], [[Mycobacterium bovis]], BCG
	* Fungi: [[Aspergillus fumigatus]], [[Histoplasma capsulatum]], [[Coccidioides]], [[Cryptococcus neoformans]], [[Candida albicans]]		* Fungi: [[Aspergillus fumigatus]], [[Histoplasma capsulatum]], [[Coccidioides]], [[Cryptococcus neoformans]], [[Candida albicans]]
	* Parasites: [[Toxoplasma gondii]]		* Parasites: [[Toxoplasma gondii]]

Aidan: Text replacement - " species]]" to "]]"

2022-02-08T02:49:03Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 02:49, 8 February 2022
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	== Infections ==		== Infections ==

	* Bacteria: [[septic arthritis]], [[Listeria monocytogenes]], [[Legionella ~~species~~]], [[Nocardia ~~species~~]], [[Actinomyces ~~species~~]], [[Salmonella ~~species~~]]		* Bacteria: [[septic arthritis]], [[Listeria monocytogenes]], [[Legionella]], [[Nocardia]], [[Actinomyces]], [[Salmonella]]
	* Mycobacteria: [[Mycobacterium tuberculosis]], [[Mycobacterium avium]], [[Mycobacterium bovis]], BCG		* Mycobacteria: [[Mycobacterium tuberculosis]], [[Mycobacterium avium]], [[Mycobacterium bovis]], BCG
	* Fungi: [[Aspergillus fumigatus]], [[Histoplasma capsulatum]], [[Coccidioides ~~species~~]], [[Cryptococcus neoformans]], [[Candida albicans]]		* Fungi: [[Aspergillus fumigatus]], [[Histoplasma capsulatum]], [[Coccidioides]], [[Cryptococcus neoformans]], [[Candida albicans]]
	* Parasites: [[Toxoplasma gondii]]		* Parasites: [[Toxoplasma gondii]]
	* Viruses: [[hepatitis B virus]], [[hepatitis C virus]], [[varicella-zoster virus]]		* Viruses: [[hepatitis B virus]], [[hepatitis C virus]], [[varicella-zoster virus]]

Aidan: Created page with "== Contraindications == * Active bacterial infection, active tuberculosis or untreated LTBI, active herpes zoster infection, active invasive fungal infection, infected skin u..."

2020-08-16T19:42:28Z

Created page with "== Contraindications == * Active bacterial infection, active tuberculosis or untreated LTBI, active herpes zoster infection, active invasive fungal infection, infected skin u..."

New page

== Contraindications ==

* Active bacterial infection, active tuberculosis or untreated LTBI, active herpes zoster infection, active invasive fungal infection, infected skin ulcers, acute hepatitis B or C, untreated chronic hepatitis B, or chronic hepatitis B or C with Child-Pugh B or C

== Infections ==

* Bacteria: [[septic arthritis]], [[Listeria monocytogenes]], [[Legionella species]], [[Nocardia species]], [[Actinomyces species]], [[Salmonella species]]
* Mycobacteria: [[Mycobacterium tuberculosis]], [[Mycobacterium avium]], [[Mycobacterium bovis]], BCG
* Fungi: [[Aspergillus fumigatus]], [[Histoplasma capsulatum]], [[Coccidioides species]], [[Cryptococcus neoformans]], [[Candida albicans]]
* Parasites: [[Toxoplasma gondii]]
* Viruses: [[hepatitis B virus]], [[hepatitis C virus]], [[varicella-zoster virus]]
* Screening prior to use should be done for [[LTBI]] (TST or IGRA), [[hepatitis B]], [[hepatitis C]], and [[HIV]]

[[Category:Immunocompromised hosts]]
[[Category:Rheumatology]]
[[Category:Medications]]