Trimethoprim-sulfamethoxazole - Revision history

Aidan at 19:38, 31 December 2025

2025-12-31T19:38:32Z

← Older revision		Revision as of 19:38, 31 December 2025
Line 43:		Line 43:
	** Other infections: 8 to 12 mg/kg/day IV/PO divided q8-12h (max 960 mg total daily dose)		** Other infections: 8 to 12 mg/kg/day IV/PO divided q8-12h (max 960 mg total daily dose)
	*[[Nocardia]]: 10 mg/kg TDD		*[[Nocardia]]: 10 mg/kg TDD
	*[[Pneumocystis jirovecii]]~~: 15-20 mg/kg TDD~~		*[[Pneumocystis jirovecii]]
			**Treatment: 15-20 mg/kg TDD
			**Prophylaxis: DS tab once daily; or SS tab once daily; or DS tab three times weekly
	*CNS infections: 15-20 mg/kg TDD		*CNS infections: 15-20 mg/kg TDD

Aidan: /* Intravenous Dosing */

2024-09-27T16:37:01Z

Intravenous Dosing

← Older revision		Revision as of 16:37, 27 September 2024
Line 54:		Line 54:
	* 10 to 20 mg/kg TMP total daily dose, split TID to QID		* 10 to 20 mg/kg TMP total daily dose, split TID to QID

	{\| class="wikitable"		{\| class="wikitable sortable"
	!Dose (TMP)		!Dose (TMP)
	! Weight (kg)		! Weight (kg)

Aidan at 18:04, 20 August 2024

2024-08-20T18:04:33Z

← Older revision		Revision as of 18:04, 20 August 2024
Line 53:		Line 53:

	* 10 to 20 mg/kg TMP total daily dose, split TID to QID		* 10 to 20 mg/kg TMP total daily dose, split TID to QID

	==== TMP 10 mg/kg per day ====

	{\| class="wikitable"		{\| class="wikitable"
		⚫	!Dose (TMP)
	! Weight (kg)		! Weight (kg)
	! Total dose TMP (mg/day)		! Total dose TMP (mg/day)
Line 62:		Line 61:
	!Dose (PO)		!Dose (PO)
	\|-		\|-
			\| rowspan="5" \|10 mg/kg
	\| 40-49		\| 40-49
	\| 480		\| 480
Line 86:		Line 86:
	\| 20 mL q6h		\| 20 mL q6h
	\|2 DS tabs q6h		\|2 DS tabs q6h
	\|}

	==== TMP 15 mg/kg per day ====

	{\| class="wikitable"
	! Weight (kg)
	! Total dose TMP (mg/day)
	! Dose (IV)
⚫	!Dose (PO)
	\|-		\|-
			\| rowspan="9" \|15 mg/kg
	\| 40-44		\|40-44
	\| 640		\|640
	\| 10 mL q6h		\|10 mL q6h
	\|1 DS tab q6h, or 2 DS tabs q12h		\|1 DS tab q6h, or 2 DS tabs q12h
	\|-		\|-
	\| 45-49		\|45-49
	\| 720		\|720
	\| 15 mL q8h		\|15 mL q8h
	\|3 SS tabs q8h		\|3 SS tabs q8h
	\|-		\|-
	\| 50-69		\|50-69
	\| 960		\|960
	\| 15 mL q6h		\|15 mL q6h
	\|2 DS tabs q8h, or 3 SS tabs q6h		\|2 DS tabs q8h, or 3 SS tabs q6h
	\|-		\|-
	\| 70-79		\|70-79
	\| 1200		\|1200
	\| 25 mL q8h		\|25 mL q8h
	\|5 SS tabs q8h		\|5 SS tabs q8h
	\|-		\|-
	\| 80-89		\|80-89
	\| 1280		\|1280
	\| 20 mL q6h		\|20 mL q6h
	\|2 DS tabs q6h		\|2 DS tabs q6h
	\|-		\|-
	\| 90-99		\|90-99
	\| 1440		\|1440
	\| 30 mL q8h		\|30 mL q8h
	\|3 DS tabs q8h		\|3 DS tabs q8h
	\|-		\|-
	\| 100-109		\|100-109
	\| 1600		\|1600
	\| 25 mL q6h		\|25 mL q6h
	\|2/2/3/3 DS tabs q6h, or 5 SS tabs q6h		\|2/2/3/3 DS tabs q6h, or 5 SS tabs q6h
	\|-		\|-
	\| 110-119		\|110-119
	\| 1680		\|1680
	\| 35 mL q8h		\|35 mL q8h
	\|7 SS tabs q8h		\|7 SS tabs q8h
	\|-		\|-
	\| 120-129		\|120-129
	\| 1920		\|1920
	\| 30 mL q6h		\|30 mL q6h
	\|3 DS tabs q6h		\|3 DS tabs q6h
	\|}

	==== TMP 20 mg/kg per day ====

	{\| class="wikitable"
	! Weight (kg)
	! Total dose TMP (mg/day)
	! Dose (IV)
	!Dose (PO)
	\|-		\|-
			\| rowspan="7" \|20 mg/kg
	\| 40-54		\|40-54
	\| 960		\|960
	\| 15 mL q6h		\|15 mL q6h
	\|2 DS tabs q8h, or 3 SS tabs q6h		\|2 DS tabs q8h, or 3 SS tabs q6h
	\|-		\|-
	\| 55-69		\|55-69
	\| 1280		\|1280
	\| 20 mL q6h		\|20 mL q6h
	\|2 DS tabs q6h		\|2 DS tabs q6h
	\|-		\|-
	\| 70-79		\|70-79
	\| 1440		\|1440
	\| 30 mL q8h		\|30 mL q8h
	\|3 DS tabs q8h		\|3 DS tabs q8h
	\|-		\|-
	\| 80-89		\|80-89
	\| 1600		\|1600
	\| 25 mL q6h		\|25 mL q6h
	\|2/2/3/3 DS tabs q6h, or 5 SS tabs q6h		\|2/2/3/3 DS tabs q6h, or 5 SS tabs q6h
	\|-		\|-
	\| 90-104		\|90-104
	\| 1920		\|1920
	\| 30 mL q6h		\|30 mL q6h
	\|3 DS tabs q6h		\|3 DS tabs q6h
	\|-		\|-
	\| 105-119		\|105-119
	\| 2240		\|2240
	\| 35 mL q6h		\|35 mL q6h
	\|3/3/4/4 DS tabs q6h, or 7 SS tabs q6h		\|3/3/4/4 DS tabs q6h, or 7 SS tabs q6h
	\|-		\|-
	\| 120-134		\|120-134
	\| 2560		\|2560
	\| 40 mL q6h		\|40 mL q6h
	\|4 DS tabs q6h		\|4 DS tabs q6h
	\|}		\|}

	=== Renal Dosing ===		==== Renal Dosing ====

	{\| class="wikitable"		{\| class="wikitable"

Aidan at 04:00, 16 July 2024

2024-07-16T04:00:27Z

← Older revision		Revision as of 04:00, 16 July 2024
Line 40:		Line 40:

	* Resistant Gram-negative infections		* Resistant Gram-negative infections
	** [[Cystitis]]: 160 mg (1 SS tab) IV/PO q12h		** [[Cystitis]] or [[pyelonephritis]]: 160 mg/800 mg (1 DS tab) IV/PO q12h
	** Other infections: 8 to 12 mg/kg/day IV/PO divided q8-12h (max 960 mg total daily dose)		** Other infections: 8 to 12 mg/kg/day IV/PO divided q8-12h (max 960 mg total daily dose)
	*[[Nocardia]]: 10 mg/kg TDD		*[[Nocardia]]: 10 mg/kg TDD

Aidan: added some dosing guidelines

2022-03-30T14:00:53Z

added some dosing guidelines

← Older revision		Revision as of 14:00, 30 March 2022
Line 42:		Line 42:
	** [[Cystitis]]: 160 mg (1 SS tab) IV/PO q12h		** [[Cystitis]]: 160 mg (1 SS tab) IV/PO q12h
	** Other infections: 8 to 12 mg/kg/day IV/PO divided q8-12h (max 960 mg total daily dose)		** Other infections: 8 to 12 mg/kg/day IV/PO divided q8-12h (max 960 mg total daily dose)
			*[[Nocardia]]: 10 mg/kg TDD
			*[[Pneumocystis jirovecii]]: 15-20 mg/kg TDD
			*CNS infections: 15-20 mg/kg TDD

	=== Oral Dosing ===		=== Oral Dosing ===

Aidan: added weight based oral dosing equivalents

2022-03-30T13:58:19Z

added weight based oral dosing equivalents

Show changes

Aidan: /* Adverse Drug Reactions */

2022-03-30T13:38:31Z

Adverse Drug Reactions

← Older revision		Revision as of 13:38, 30 March 2022
Line 187:		Line 187:
	* [[Adverse drug reaction::GI upset]], including nausea at higher doses		* [[Adverse drug reaction::GI upset]], including nausea at higher doses
	* [[Adverse drug reaction::Drug-drug interactions]]		* [[Adverse drug reaction::Drug-drug interactions]]
	** Increases warfarin levels		** Increases [[warfarin]] levels
	* [[Adverse drug reaction::Anemia]], [[Adverse drug reaction::neutropenia]] and [[Adverse drug reaction::thrombocytopenia]]		* [[Adverse drug reaction::Anemia]], [[Adverse drug reaction::neutropenia]] and [[Adverse drug reaction::thrombocytopenia]]
	** It is a mild folate antagonist		** It is a mild folate antagonist

Aidan at 19:20, 24 November 2021

2021-11-24T19:20:09Z

← Older revision		Revision as of 19:20, 24 November 2021
Line 1:		Line 1:
	== ~~Identification~~ ==		== Background ==

	* Sulfonamide antibiotic		* Sulfonamide antibiotic

	== Brand Names ==		=== Brand Names ===

	* Septra		* Septra
Line 11:		Line 10:
	== Dosing ==		== Dosing ==

	~~Based~~ on the trimethroprim component.		* Traditionally based on the trimethroprim component

	{\| class="wikitable"		{\| class="wikitable"
Line 35:		Line 34:
	\|}		\|}

	Conversion: 2 SS tabs = 1 DS tab = 20 mL oral suspension = 10 mL IV		* Conversion: 2 SS tabs = 1 DS tab = 20 mL oral suspension = 10 mL IV
			* Resistant Gram-negative infections
			** [[Cystitis]]: 160 mg (1 SS tab) IV/PO q12h
			** Other infections: 8 to 12 mg/kg/day IV/PO divided q8-12h (max 960 mg total daily dose)

	=== Oral Dosing ===		=== Oral Dosing ===

Aidan: /* Further Reading */

2020-08-03T11:29:12Z

Aidan: /* Notable Side Effects */

2020-02-18T14:03:31Z

Notable Side Effects

← Older revision		Revision as of 14:03, 18 February 2020
Line 181:		Line 181:
	\|}		\|}

	== ~~Notable~~ ~~Side~~ ~~Effects~~ ==		== Adverse Drug Reactions ==
		⚫	* Allergic reactions, including [[Adverse drug reaction::anaphylaxis]] and a relatively high rate of [[Adverse drug reaction::SJS]]/[[Adverse drug reaction::TEN]]

		⚫	* [[Adverse drug reaction::GI upset]], including nausea at higher doses
⚫	* Allergic reactions, including anaphylaxis and a relatively high rate of SJS/TEN
			* [[Adverse drug reaction::Drug-drug interactions]]
⚫	* GI upset, including nausea at higher doses
	* Interactions
	** Increases warfarin levels		** Increases warfarin levels
	* Anemia, neutropenia and thrombocytopenia		* [[Adverse drug reaction::Anemia]], [[Adverse drug reaction::neutropenia]] and [[Adverse drug reaction::thrombocytopenia]]
	** It is a mild folate antagonist		** It is a mild folate antagonist
	* Hepatotoxicity		* [[Adverse drug reaction::Hepatotoxicity]]
	* Hyperkalemia		* [[Adverse drug reaction::Hyperkalemia]]
	* Hypoglycemia		* [[Adverse drug reaction::Hypoglycemia]]
	* Acute kidney injury, though it also increases tubular creatinine reabsorption		* [[Adverse drug reaction::Acute kidney injury]], though it also increases tubular creatinine reabsorption
	* Renal tubular acidosis		* [[Adverse drug reaction::Renal tubular acidosis]]

	== Further Reading ==		== Further Reading ==

← Older revision		Revision as of 11:29, 3 August 2020
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	== Further Reading ==		== Further Reading ==

	* ~~Review of adverse effects: [https://doi.org/10.1503/cmaj.111152~~ Considerations when prescribing trimethoprim-sulfamethoxazole]. ''CMAJ''. 2011(16):1851-1858		* Considerations when prescribing trimethoprim-sulfamethoxazole. ''CMAJ''. 2011;183(16):1851-1858. doi: [https://doi.org/10.1503/cmaj.111152 10.1503/cmaj.111152]
			** Review of adverse events

	[[Category:Antibiotics]]		[[Category:Antibiotics]]