Tocilizumab - Revision history

Aidan at 14:58, 6 May 2025

2025-05-06T14:58:10Z

@@ Line 6: / Line 6: @@
 ==Dosing==
-*[[SARS-CoV-2]] with acutely declining patients, as a single dose infused over 60 minutes
+*Severe or critical [[COVID-19]], as a single dose infused over 60 minutes
 ==Safety==
@@ Line 20: / Line 45: @@
 ===Infections===
-*In one cohort study, serious bacterial infections occured in about 7%, with no viral or fungal infections seen[[CiteRef::lang2011ri]]
+*In one cohort study, serious bacterial infections occurred in about 7%, with no viral or fungal infections seen[[CiteRef::lang2011ri]]
 *Compared to [[TNF-α inhibitors]], has a higher risk of serious bacterial infection, [[skin and soft tissue infection]], and [[diverticulitis]][[CiteRef::pawar2019ri]]

Aidan at 23:00, 13 January 2022

2022-01-13T23:00:42Z

← Older revision		Revision as of 23:00, 13 January 2022
Line 2:		Line 2:

	*IL-6 antagonist		*IL-6 antagonist
			*Indicated for [[COVID-19]]

	==Dosing==		==Dosing==
Line 12:		Line 13:

	==Safety==		==Safety==

			=== Contraindications ===

			* Contraindications and relative contraindications include hypersensitivity, co-existing infection, immunosuppression, increase liver enzymes.

	===Infections===		===Infections===

Aidan: /* Infections */

2021-02-25T18:53:56Z

Infections

← Older revision		Revision as of 18:53, 25 February 2021
Line 11:		Line 11:
	**Weight >90 kg: 800 mg		**Weight >90 kg: 800 mg

	== Safety ==		==Safety==

	=== Infections ===		===Infections===

			*In one cohort study, serious bacterial infections occured in about 7%, with no viral or fungal infections seen[[CiteRef::lang2011ri]]
	* Compared to [[TNF-α inhibitors]], has a higher risk of serious bacterial infection, [[skin and soft tissue infection]], and [[diverticulitis]][[CiteRef::pawar2019ri]]
	* ~~There~~ ~~does~~ ~~not~~ ~~appear~~ to ~~be an increased~~ risk of ~~non-~~bacterial ~~infections~~[[CiteRef::~~lang2011ri~~]]		*Compared to [[TNF-α inhibitors]], has a higher risk of serious bacterial infection, [[skin and soft tissue infection]], and [[diverticulitis]][[CiteRef::pawar2019ri]]

	[[Category:Medications]]		[[Category:Medications]]

Aidan at 18:50, 25 February 2021

2021-02-25T18:50:40Z

← Older revision		Revision as of 18:50, 25 February 2021
Line 10:		Line 10:
	**Weight >65 and ≤90 kg: 600 mg		**Weight >65 and ≤90 kg: 600 mg
	**Weight >90 kg: 800 mg		**Weight >90 kg: 800 mg

			== Safety ==

			=== Infections ===

			* Compared to [[TNF-α inhibitors]], has a higher risk of serious bacterial infection, [[skin and soft tissue infection]], and [[diverticulitis]][[CiteRef::pawar2019ri]]
			* There does not appear to be an increased risk of non-bacterial infections[[CiteRef::lang2011ri]]

	[[Category:Medications]]		[[Category:Medications]]

Aidan: /* Dosing */

2021-02-24T18:50:33Z

Dosing

← Older revision		Revision as of 18:50, 24 February 2021
Line 1:		Line 1:
	== Background ==		==Background==

	* IL-6 antagonist		*IL-6 antagonist

	== Dosing ==		==Dosing==

	* ~~COVID~~-19, as a single dose infused over 60 minutes		*[[SARS-CoV-2]] with acutely declining patients, as a single dose infused over 60 minutes
	** Weight ≤40 kg: 8 mg/kg		**Weight ≤40 kg: 8 mg/kg
	** Weight >40 and ≤65 kg: 400 mg		**Weight >40 and ≤65 kg: 400 mg
	** Weight >65 and ≤90 kg: 600 mg		**Weight >65 and ≤90 kg: 600 mg
	** Weight >90 kg: 800 mg		**Weight >90 kg: 800 mg

	[[Category:Medications]]		[[Category:Medications]]

Aidan: Created page with "== Background == * IL-6 antagonist == Dosing == * COVID-19, as a single dose infused over 60 minutes Weight ≤40 kg: 8 mg/kg Weight >40 and ≤65 kg: 400 mg ** Weigh..."

2021-02-16T02:17:27Z

Created page with "== Background == * IL-6 antagonist == Dosing == * COVID-19, as a single dose infused over 60 minutes ** Weight ≤40 kg: 8 mg/kg ** Weight >40 and ≤65 kg: 400 mg ** Weigh..."

New page

== Background ==

* IL-6 antagonist

== Dosing ==

* COVID-19, as a single dose infused over 60 minutes
** Weight ≤40 kg: 8 mg/kg
** Weight >40 and ≤65 kg: 400 mg
** Weight >65 and ≤90 kg: 600 mg
** Weight >90 kg: 800 mg

[[Category:Medications]]