Tigecycline - Revision history

Aidan at 12:56, 26 April 2021

2021-04-26T12:56:54Z

← Older revision		Revision as of 12:56, 26 April 2021
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	== Background ==		==Background==

	*Glycylcycline antibiotic		*Glycylcycline antibiotic
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	*Does cover [[Acinetobacter]] and [[Stenotrophomonas]]		*Does cover [[Acinetobacter]] and [[Stenotrophomonas]]

	=== Pharmacokinetics and Pharmacodynamics ===		===Pharmacokinetics and Pharmacodynamics===

	* Rapidly concentrates in tissue, but poor concentration in urine and lung tissue		*Rapidly concentrates in tissue, but poor concentration in urine and lung tissue

	== Dosing ==		==Dosing==

	* ~~High~~ ~~dosing~~ ~~may~~ be ~~useful~~ in ~~HAP/VAP~~ ~~with 100~~ mg IV q12h		*'''Intraabdominal infection:''' 100 mg IV load followed by 50 mg IV q12h
			*'''Pneumonia:''' 100 mg IV load followed by 50 mg IV q12h
			**High dosing may be useful in HAP/VAP with 100 mg IV q12h
			*'''Skin and soft tissue infection:''' 100 mg IV load followed by 50 mg IV q12h

	== Safety ==		==Safety==

	* Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP		*Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP
			*Commonly causes nausea, vomiting, and diarrhea
			*Also anemia, thrombocytopenia, hepatitis, jaundice, AKI

	[[Category:Glycylcyclines]]		[[Category:Glycylcyclines]]

Aidan at 13:29, 3 February 2021

2021-02-03T13:29:48Z

← Older revision		Revision as of 13:29, 3 February 2021
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			== Background ==

	*Glycylcycline antibiotic		*Glycylcycline antibiotic

	== Spectrum of Activity ==		===Spectrum of Activity===

	*Related to [[tetracycline]] and [[doxycycline]], with expanded coverage to include [[streptococci]] and [[Enterobacteriaceae]], but without coverage for unusual [[Gram-negative bacteria]] or [[Chlamydia trachomatis]]		*Related to [[tetracycline]] and [[doxycycline]], with expanded coverage to include [[streptococci]] and [[Enterobacteriaceae]], but without coverage for unusual [[Gram-negative bacteria]] or [[Chlamydia trachomatis]]
	*Does cover [[Acinetobacter]] and [[Stenotrophomonas]]		*Does cover [[Acinetobacter]] and [[Stenotrophomonas]]

			=== Pharmacokinetics and Pharmacodynamics ===

			* Rapidly concentrates in tissue, but poor concentration in urine and lung tissue

			== Dosing ==

			* High dosing may be useful in HAP/VAP with 100 mg IV q12h

			== Safety ==

			* Black box warning for increased all-cause mortality (4 vs 3%), likely driven by standard dosing tigecycline in VAP

	[[Category:Glycylcyclines]]		[[Category:Glycylcyclines]]

Aidan at 17:26, 20 August 2020

2020-08-20T17:26:46Z

← Older revision		Revision as of 17:26, 20 August 2020
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	*Does cover [[Acinetobacter]] and [[Stenotrophomonas]]		*Does cover [[Acinetobacter]] and [[Stenotrophomonas]]

	[[Category:~~Glycyclcyclines~~]]		[[Category:Glycylcyclines]]

Aidan at 17:25, 20 August 2020

2020-08-20T17:25:46Z

← Older revision		Revision as of 17:25, 20 August 2020
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	* Glycylcycline antibiotic		*Glycylcycline antibiotic

⚫	* Related to [[tetracycline]] and [[doxycycline]], with expanded coverage to include [[streptococci]]~~, [[Enterobacteriaceae]],~~ and [[~~Acinetobacter~~]], but without coverage for unusual [[Gram-negative bacteria]] or [[Chlamydia trachomatis]]
			== Spectrum of Activity ==

		⚫	*Related to [[tetracycline]] and [[doxycycline]], with expanded coverage to include [[streptococci]] and [[Enterobacteriaceae]], but without coverage for unusual [[Gram-negative bacteria]] or [[Chlamydia trachomatis]]
			*Does cover [[Acinetobacter]] and [[Stenotrophomonas]]

	[[Category:Glycyclcyclines]]		[[Category:Glycyclcyclines]]

Aidan: Created page with "* Glycylcycline antibiotic * Related to tetracycline and doxycycline, with expanded coverage to include streptococci, Enterobacteriaceae, and Acinetobacter..."

2020-08-20T17:24:51Z

Created page with "* Glycylcycline antibiotic * Related to tetracycline and doxycycline, with expanded coverage to include streptococci, Enterobacteriaceae, and Acinetobacter..."

New page

* Glycylcycline antibiotic
* Related to [[tetracycline]] and [[doxycycline]], with expanded coverage to include [[streptococci]], [[Enterobacteriaceae]], and [[Acinetobacter]], but without coverage for unusual [[Gram-negative bacteria]] or [[Chlamydia trachomatis]]

[[Category:Glycyclcyclines]]