Tick-borne relapsing fever - Revision history

Aidan: Text replacement - " species]]" to "]]"

2022-02-08T02:52:15Z

Text replacement - " species]]" to "]]"

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	===Microbiology===		===Microbiology===

	*Tick-borne relapsing fever is caused by multiple non-Lyme ''Borrelia'' species with global distribution, usually carried by [[Ornithodorus ~~species~~]] ticks		*Tick-borne relapsing fever is caused by multiple non-Lyme ''Borrelia'' species with global distribution, usually carried by [[Ornithodorus]] ticks
	*Other non-Lyme ''Borrelia'' species include ''B. miyamotoi'' and ''B. lonestari'', although ''B. lonestari'' may also be able to cause TBRF		*Other non-Lyme ''Borrelia'' species include ''B. miyamotoi'' and ''B. lonestari'', although ''B. lonestari'' may also be able to cause TBRF
	*''Borrelia'' are [[Shape::spirochete\|spirochetes]]		*''Borrelia'' are [[Shape::spirochete\|spirochetes]]
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	===Epidemiology===		===Epidemiology===

	*TBRF is transmitted by [[Vector::Ornithodoros ~~species~~]] ticks, with rodent reservoirs		*TBRF is transmitted by [[Vector::Ornithodoros]] ticks, with rodent reservoirs
	*Present on every continent except Australia and Antarctica		*Present on every continent except Australia and Antarctica
	*In North America, it is mostly in the Rocky Mountain regions above 1500 feet elevation		*In North America, it is mostly in the Rocky Mountain regions above 1500 feet elevation

Aidan: Text replacement - "[[Cellular shape::" to "[[Shape::"

2020-10-08T14:22:00Z

Text replacement - "[[Cellular shape::" to "[[Shape::"

← Older revision		Revision as of 14:22, 8 October 2020
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	*Tick-borne relapsing fever is caused by multiple non-Lyme ''Borrelia'' species with global distribution, usually carried by [[Ornithodorus species]] ticks		*Tick-borne relapsing fever is caused by multiple non-Lyme ''Borrelia'' species with global distribution, usually carried by [[Ornithodorus species]] ticks
	*Other non-Lyme ''Borrelia'' species include ''B. miyamotoi'' and ''B. lonestari'', although ''B. lonestari'' may also be able to cause TBRF		*Other non-Lyme ''Borrelia'' species include ''B. miyamotoi'' and ''B. lonestari'', although ''B. lonestari'' may also be able to cause TBRF
	*''Borrelia'' are [[~~Cellular shape~~::spirochete\|spirochetes]]		*''Borrelia'' are [[Shape::spirochete\|spirochetes]]
	*Serotypes are determined by the outer membrane variable major proteins (vmp)		*Serotypes are determined by the outer membrane variable major proteins (vmp)
	*Grow in modified Kelly medium and stained by Wright stain (in peripheral blood film)		*Grow in modified Kelly medium and stained by Wright stain (in peripheral blood film)

Aidan: /* Tick-borne relapsing fever */

2020-09-04T00:42:22Z

Tick-borne relapsing fever

← Older revision		Revision as of 00:42, 4 September 2020
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	==Management==		==Management==
	===Tick-borne relapsing fever===

	*First-line: [[Is treated by::doxycycline]] 100 mg po bid for 7 to 10 days		*First-line: [[Is treated by::doxycycline]] 100 mg po bid for 7 to 10 days

Aidan: /* Clinical Presentation */

2020-09-03T09:47:12Z

Clinical Presentation

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	*May be septic, with multiple organ involvement		*May be septic, with multiple organ involvement
	*Can cause spontaneous abortion in pregnant women		*Can cause spontaneous abortion in pregnant women
	*May have a Jarisch-Herxheimer reaction following ~~empiric~~ antibiotics		*May have a [[Causes::Jarisch-Herxheimer]] reaction following antibiotics

	==Differential Diagnosis==		==Differential Diagnosis==

Aidan: /* Clinical Presentation */

2020-08-29T10:33:30Z

Clinical Presentation

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	**A minority of patients will have lymphadenopathy, hepatosplenomegaly, a rash, dysuria, jaundice		**A minority of patients will have lymphadenopathy, hepatosplenomegaly, a rash, dysuria, jaundice
	*Rare complications include lymphocytic meningitis, Bell palsy and other cranial nerve palsies, paralysis, seizure, uveitis, endophthalmitis, ARDS, and myocarditis		*Rare complications include lymphocytic meningitis, Bell palsy and other cranial nerve palsies, paralysis, seizure, uveitis, endophthalmitis, ARDS, and myocarditis
			*[[Causes::Thrombocytopenia]] on bloodwork
	*May be septic, with multiple organ involvement		*May be septic, with multiple organ involvement
	*Can cause spontaneous abortion in pregnant women		*Can cause spontaneous abortion in pregnant women

Aidan: /* Clinical Presentation */

2020-08-29T10:26:24Z

Clinical Presentation

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	*TBRF can relapse up to 30 times, whereas LBRF is usually self-limited after a single relapse		*TBRF can relapse up to 30 times, whereas LBRF is usually self-limited after a single relapse
	**Febrile periods may be associated with [[Causes::headache]], [[Causes::myalgias]], [[Causes::chills]], [[Causes::arthralgias]], [[Causes::dizziness]], and [[Causes::vomiting]]		**Febrile periods may be associated with [[Causes::headache]], [[Causes::myalgias]], [[Causes::chills]], [[Causes::arthralgias]], [[Causes::dizziness]], and [[Causes::vomiting]]
	**Sometimes [[Causes:abdominal pain]], [[Causes::confusion]], [[Causes::non-productive cough]], [[Causes::eye pain]], [[Causes::diarrhea]], [[Causes::photophobia]], and [[Causes::neck pain]]		**Sometimes [[Causes::abdominal pain]], [[Causes::confusion]], [[Causes::non-productive cough]], [[Causes::eye pain]], [[Causes::diarrhea]], [[Causes::photophobia]], and [[Causes::neck pain]]
	**Each relapse is usually less severe		**Each relapse is usually less severe
	**A minority of patients will have lymphadenopathy, hepatosplenomegaly, a rash, dysuria, jaundice		**A minority of patients will have lymphadenopathy, hepatosplenomegaly, a rash, dysuria, jaundice

Aidan at 10:26, 29 August 2020

2020-08-29T10:26:13Z

Aidan: /* Clinical Presentation */

2020-08-05T13:57:20Z

Clinical Presentation

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	==Clinical Presentation==		==Clinical Presentation==

	*Incubation period of 7 days (range 2 to 18 days)		*Incubation period of [[Usual incubation period::7 days]] (range [[Incubation period range::2 to 18 days]])
	*Relapsing fevers: febrile for 3 days, afebrile for 7 days		*Relapsing fevers: febrile for 3 days, afebrile for 7 days
	*TBRF can relapse up to 30 times, whereas LBRF is usually self-limited after a single relapse		*TBRF can relapse up to 30 times, whereas LBRF is usually self-limited after a single relapse

Aidan: /* Microbiology */ linkified

2020-08-02T12:10:30Z

Microbiology: linkified

Show changes

Aidan: /* Prevention */

2019-10-28T17:37:41Z

Prevention

← Older revision		Revision as of 17:37, 28 October 2019
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	== Prevention ==		== Prevention ==
	* Can do post-exposure prophylaxis with doxycycline 200 mg po once followed by 100 mg daily for 4 days		* Can do post-exposure prophylaxis with [[doxycycline]] 200 mg po once followed by 100 mg daily for 4 days

	[[Category:Borrelioses]]		[[Category:Borrelioses]]

← Older revision		Revision as of 10:26, 29 August 2020
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	!Species!!Vector!!Distribution!!Reservoir		!Species!!Vector!!Distribution!!Reservoir
	\|-		\|-
	\|''[[Borrelia hermsii\|B. hermsii]]''\|\|''O. hermsii''\|\|Western US and Canada (most common)\|\|~~Rodent~~		\|''[[Borrelia hermsii\|B. hermsii]]''\|\|''O. hermsii''\|\|Western US and Canada (most common)\|\|squirrels and chipmucks
	\|-		\|-
	\|''[[Borrelia turicatae\|B. turicatae]]''\|\|''O. turicata''\|\|Southwestern US\|\|Rodent		\|''[[Borrelia turicatae\|B. turicatae]]''\|\|''O. turicata''\|\|Southwestern US\|\|Rodent
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	*Incubation period of [[Usual incubation period::7 days]] (range [[Incubation period range::2 to 18 days]])		*Incubation period of [[Usual incubation period::7 days]] (range [[Incubation period range::2 to 18 days]])
	*Relapsing ~~fevers~~: febrile for 3 days, afebrile for 7 days		*[[Causes::Relapsing fever]]: febrile for 3 days (range 12 hours to 17 days), afebrile for 7 days
	*TBRF can relapse up to 30 times, whereas LBRF is usually self-limited after a single relapse		*TBRF can relapse up to 30 times, whereas LBRF is usually self-limited after a single relapse
	**Febrile periods may be associated with headache, ~~myalgia~~, ~~arthralgia~~, dizziness, and vomiting		**Febrile periods may be associated with [[Causes::headache]], [[Causes::myalgias]], [[Causes::chills]], [[Causes::arthralgias]], [[Causes::dizziness]], and [[Causes::vomiting]]
			**Sometimes [[Causes:abdominal pain]], [[Causes::confusion]], [[Causes::non-productive cough]], [[Causes::eye pain]], [[Causes::diarrhea]], [[Causes::photophobia]], and [[Causes::neck pain]]
	**Each relapse is usually less severe		**Each relapse is usually less severe
	*~~Some~~ patients will have lymphadenopathy, hepatosplenomegaly, ~~and~~ a rash		**A minority of patients will have lymphadenopathy, hepatosplenomegaly, a rash, dysuria, jaundice
	*Rare complications include lymphocytic meningitis, Bell palsy and other cranial nerve palsies, paralysis, seizure, uveitis, endophthalmitis, ARDS, and myocarditis		*Rare complications include lymphocytic meningitis, Bell palsy and other cranial nerve palsies, paralysis, seizure, uveitis, endophthalmitis, ARDS, and myocarditis
⚫	*Can cause spontaneous abortion in pregnant women
	*May be septic, with multiple organ involvement		*May be septic, with multiple organ involvement
		⚫	*Can cause spontaneous abortion in pregnant women
	*May have a Jarisch-Herxheimer reaction following empiric antibiotics		*May have a Jarisch-Herxheimer reaction following empiric antibiotics