https://idwiki.org/index.php?action=history&feed=atom&title=Thrombotic_thrombocytopenia_purpuraThrombotic thrombocytopenia purpura - Revision history2026-04-29T17:00:14ZRevision history for this page on the wikiMediaWiki 1.43.8https://idwiki.org/index.php?title=Thrombotic_thrombocytopenia_purpura&diff=5981&oldid=prevAidan: Created page with "== Background == * One of the thrombotic microangiopathies === Pathophysiology === * Caused by acquired or inherited deficiency of the ADAMTS..."2020-08-15T11:12:31Z<p>Created page with "== Background == * One of the <a href="/Thrombotic_microangiopathy" title="Thrombotic microangiopathy">thrombotic microangiopathies</a> === Pathophysiology === * Caused by acquired or inherited deficiency of the ADAMTS..."</p>
<p><b>New page</b></p><div>== Background ==<br />
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* One of the [[Thrombotic microangiopathy|thrombotic microangiopathies]]<br />
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=== Pathophysiology ===<br />
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* Caused by acquired or inherited deficiency of the ADAMTS13 metalloprotease<br />
** Acquired is via autoantibody<br />
* ADAMTS13 normally breaks larger von Willebrand factor multimers into smaller particles<br />
* This deficiency results in increased high-molecular-weight vWF, which aggregates and activates platelets<br />
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== Clinical Manifestations ==<br />
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* Presents as a triad of [[fever]], [[thrombocytopenia]], [[microangiopathic hemolytic anemia]], neurologic deficits, and [[acute renal failure]]<br />
* AKI is typically less severe than [[HUS]]<br />
* Coagulation parameters are typically less abnormal than in [[DIC]]<br />
* In inherited ADAMTS13 deficiency, symptoms tend to start during adolescence and present in episodes<br />
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[[Category:Hematology]]<br />
[[Category:Thrombosis]]<br />
[[Category:Thrombotic microangiopathies]]</div>Aidan