Aidan at 14:50, 22 February 2021

2021-02-22T14:50:50Z

← Older revision		Revision as of 14:50, 22 February 2021
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	== Alpha and Beta Thalassemias ==		==Alpha and Beta Thalassemias==

			{\| class="wikitable"
	{\|
	!		!
	! Alpha thalassemia		!Alpha thalassemia
	! Beta thalassemia		!Beta thalassemia
	\|-		\|-
	\| Epidemiology		\|Epidemiology
	\| Southern China, Malaysia, and Thailand, as well as trait in Africa		\|Southern China, Malaysia, and Thailand, as well as trait in Africa
	\| Africa and the Mediterranean		\|Africa and the Mediterranean
	\|-		\|-
	\| Genetics		\|Genetics
	\| Affects one (minima/carrier), two (minor/trait), three (HbH), or four (hydrops fetalis) of the alpha globin genes		\|Affects one (minima/carrier), two (minor/trait), three (HbH), or four (hydrops fetalis) of the alpha globin genes
	\| Affect one (minor) or both (major) of the beta globin genes; can have an intermedia with decreased function		\|Affect one (minor) or both (major) of the beta globin genes; can have an intermedia with decreased function
	\|-		\|-
	\| CBC and film		\|CBC and film
	\| Normal (carrier), or mild (minor) to moderate (HbH) microcytic anemia		\|Normal (carrier), or mild (minor) to moderate (HbH) microcytic anemia
	\| Mild (minor) to moderate (intermedia) to severe (major) microcytic anemia; target cells in major		\|Mild (minor) to moderate (intermedia) to severe (major) microcytic anemia; target cells in major
	\|-		\|-
	\| Hemoglobinalysis		\|Hemoglobinalysis
	\| Can show HbH (up to 30%) in HbH disease, or 3-8% Hb Barts in minor; silent carrier has normal		\|Can show HbH (up to 30%) in HbH disease, or 3-8% Hb Barts in minor; silent carrier has normal
	\| HbF elevated (up to 95% in major, 50% in intermedia, 5% minor); elevation of HbA2 >3.5%		\|HbF elevated (up to 95% in major, 50% in intermedia, 5% minor); elevation of HbA2 >3.5%
	\|}		\|}

	== Investigations ==		==Investigations==

	* CBC, peripheral blood film, and iron studies		*CBC, peripheral blood film, and iron studies
	** Microcytosis		**Microcytosis
	** Elevated RBC count		**Elevated RBC count
	** Normal WBC and platelet counts		**Normal WBC and platelet counts

	[[Category:Hematology]]		[[Category:Hematology]]

Maintenance script: Imported from text file

2020-07-04T01:17:58Z

Imported from text file

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== Alpha and Beta Thalassemias ==

{|
!
! Alpha thalassemia
! Beta thalassemia
|-
| Epidemiology
| Southern China, Malaysia, and Thailand, as well as trait in Africa
| Africa and the Mediterranean
|-
| Genetics
| Affects one (minima/carrier), two (minor/trait), three (HbH), or four (hydrops fetalis) of the alpha globin genes
| Affect one (minor) or both (major) of the beta globin genes; can have an intermedia with decreased function
|-
| CBC and film
| Normal (carrier), or mild (minor) to moderate (HbH) microcytic anemia
| Mild (minor) to moderate (intermedia) to severe (major) microcytic anemia; target cells in major
|-
| Hemoglobinalysis
| Can show HbH (up to 30%) in HbH disease, or 3-8% Hb Barts in minor; silent carrier has normal
| HbF elevated (up to 95% in major, 50% in intermedia, 5% minor); elevation of HbA2 >3.5%
|}

== Investigations ==

* CBC, peripheral blood film, and iron studies
** Microcytosis
** Elevated RBC count
** Normal WBC and platelet counts

[[Category:Hematology]]

Thalassemia - Revision history

Aidan at 14:50, 22 February 2021

Maintenance script: Imported from text file