Aidan: Created page with "== Background == * Previously known as ''Penicillium marneffei'' * Dimorphic fungus within the Genus::Talaromyces == Clinical Manifestations == * Most common in patients with advanced HIV, in whom it most commonly causes disseminated infection Subacute constitutional symptoms with hepatosplenomegaly, lymphadenopathy, and respiratory and GI issues Skin lesions are a late manifestation, with central-umbilicated papules that start on face and spread to trunk an..."

2025-12-29T19:54:36Z

Created page with "== Background == * Previously known as ''Penicillium marneffei'' * Dimorphic fungus within the Genus::Talaromyces == Clinical Manifestations == * Most common in patients with advanced HIV, in whom it most commonly causes disseminated infection ** Subacute constitutional symptoms with hepatosplenomegaly, lymphadenopathy, and respiratory and GI issues ** Skin lesions are a late manifestation, with central-umbilicated papules that start on face and spread to trunk an..."

New page

== Background ==

* Previously known as ''Penicillium marneffei''
* Dimorphic fungus within the [[Genus::Talaromyces]]

== Clinical Manifestations ==

* Most common in patients with advanced HIV, in whom it most commonly causes disseminated infection
** Subacute constitutional symptoms with hepatosplenomegaly, lymphadenopathy, and respiratory and GI issues
** Skin lesions are a late manifestation, with central-umbilicated papules that start on face and spread to trunk and extremities
** Often have cytopenias from bone marrow involvement

== Diagnosis ==

* Microscopy shows round-to-oval extracellular and intramacrophage yeast-like organisms measuring 3 to 6 mum in diameter with presence of a clear midline septum in dividing yeast cell
* Culture
** Grows readily in standard BACTEC blood culture media than other dimorphic fungi
** Filamentous hyphae with characteristic spore-bearing conidiophores and conidia
** Transitions from mold to yeast at 32 to 37ºC
* Histopathology may show one of three forms:
** Granulomatous reaction formed by histiocytes, lymphocytes, epithelioid, and giant cells within the reticuloendothelial organs
** Suppurative reaction that develops with the joining of multiple abscesses seen in the lung and subcutaneous tissues
** Anergic, necrotizing reaction characterized by focal necrosis surrounded by distended histiocytes containing proliferating fungi

== Management ==

* High susceptibility to [[amphotericin B]], [[voriconazole]], [[itraconazole]][[CiteRef::devi2018a]]

Talaromyces marneffei - Revision history