Aidan: Created page with "== Background == * Drug used in solid organ transplantation that has a narrow therapeutic window == Safety == === Adverse Drug Reactions === * Nephrotoxic and neurotoxic,..."

2020-09-14T16:02:46Z

Created page with "== Background == * Drug used in solid organ transplantation that has a narrow therapeutic window == Safety == === Adverse Drug Reactions === * Nephrotoxic and neurotoxic,..."

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== Background ==

* Drug used in solid organ transplantation that has a narrow therapeutic window

== Safety ==

=== Adverse Drug Reactions ===

* Nephrotoxic and neurotoxic, with risk that is proportion to serum levels
*

=== Drug-Drug Interactions ===

* It is a substrate for CYP 3A4
** [[Erythromycin]], [[clarithromycin]], [[clotrimazole]], [[fluconazole]], and [[ketoconazole]] can increase tacrolimus levels
*** Interaction with [[macrolides]] is lowest with [[azithromycin]], which should be preferred
** [[Rifampin]] can decrease tacrolimus levels and precipitate acute rejection
* Other interactions include
** [[Quinupristin-dalfopristin]] and [[chloramphenicol]] can increase tacrolimus levels
** [[Sulfonamides]] and [[vancomycin]] can increase risk of nephrotoxicity, so creatinine should be monitored closely

[[Category:Medications]]

Tacrolimus - Revision history

Aidan: Created page with "== Background == * Drug used in solid organ transplantation that has a narrow therapeutic window == Safety == === Adverse Drug Reactions === * Nephrotoxic and neurotoxic,..."