Streptobacillus moniliformis - Revision history

Aidan: /* Diagnosis */

2025-11-12T18:54:28Z

Diagnosis

← Older revision		Revision as of 18:54, 12 November 2025
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	* [[Diarrhea]] and weight loss in children		* [[Diarrhea]] and weight loss in children
	* Mortality as high as 13% if untreated		* Mortality as high as 13% if untreated

			== Differential Diagnosis ==
		⚫	* Often on the differential with [[leptospirosis]], and can mimic [[RMSF]], secondary [[syphilis]], [[Neisseria gonorrhoeae\|gonococcal infection]], [[Borrelia burgdorferi\|Lyme disease]], [[brucellosis]], [[septic arthritis]], and other

	== Diagnosis ==		== Diagnosis ==
⚫	* Often on the differential with leptospirosis, and can mimic RMSF, secondary syphilis, gonococcal infection, Lyme disease, brucellosis, septic arthritis, and other
	* On microscopy, the bacilli stain with Giemsa, acridine orange, or Gram stain		* On microscopy, the bacilli stain with Giemsa, acridine orange, or Gram stain
	* Must be cultured with specific enriched media		* Must be cultured with specific enriched media

Aidan: capitalization and links

2022-10-17T13:44:15Z

capitalization and links

← Older revision		Revision as of 13:44, 17 October 2022
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	* However, can develop a relapsing-remitting course over months, and arthritis can persist for years		* However, can develop a relapsing-remitting course over months, and arthritis can persist for years

	=== Haverhill ~~fever~~ ===		=== Haverhill Fever ===
	* When acquired from oral ingestion, can present with pharyngitis and severe vomiting, then progress to the usual		* When acquired from oral ingestion, can present with pharyngitis and severe vomiting, then progress to the usual

	=== Rare ~~sequelae~~ ===		=== Rare Sequelae ===
	* Endocarditis, myocarditis, pericarditis, sepsis, systemic vasculitis, meningitis, pneumonia, hepatitis, septic arthritis, amnionitis, and anemia		* [[Endocarditis]], [[myocarditis]], [[pericarditis]], [[sepsis]], systemic [[vasculitis]], [[meningitis]], [[pneumonia]], [[hepatitis]], [[septic arthritis]], [[amnionitis]], and [[anemia]]
	* Abscesses in any organ, including brain, liver, spleen, kidney, epidural space, bone, skin, muscle, and genital tract		* Abscesses in any organ, including brain, liver, spleen, kidney, epidural space, bone, skin, muscle, and genital tract
	* Diarrhea and weight loss in children		* [[Diarrhea]] and weight loss in children
	* Mortality as high as 13% if untreated		* Mortality as high as 13% if untreated

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	== Treatment ==		== Treatment ==
	* Penicillin G ~~12m~~ units total daily dose IV, step down to oral after a week if well		* [[Penicillin G]] 12 million units total daily dose IV, step down to oral after a week if well
	* Alternative: tetracycline 500 mg po q6h, streptomycin 7.5 mg/kg IM q12h		* Alternative: [[tetracycline]] 500 mg po q6h, [[streptomycin]] 7.5 mg/kg IM q12h
	* Duration 10 to 14 days		* Duration 10 to 14 days

	== Prevention ==		== Prevention ==
	* Rat bites should be cleansed thoroughly		* Rat bites should be cleansed thoroughly
	* Tetanus prophylaxis if appropriate		* [[Tetanus]] prophylaxis if appropriate
	* Can do 3 days of prophylactic penicillin 2 g daily divided		* Can do 3 days of prophylactic [[penicillin]] 2 g daily divided

	== Further Reading ==		== Further Reading ==

Aidan: Text replacement - "[[Has cell shape::" to "[[Shape::"

2020-10-13T02:43:30Z

Text replacement - "[[Has cell shape::" to "[[Shape::"

← Older revision		Revision as of 02:43, 13 October 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Pleomorphic, [[Has motility::non-motile]], non-sporulating, non-encapsulated filamentous [[Stain::Gram-negative]] [[~~Has cell shape~~::bacillus]]		* Pleomorphic, [[Has motility::non-motile]], non-sporulating, non-encapsulated filamentous [[Stain::Gram-negative]] [[Shape::bacillus]]
	** Often long, but can even be coccoid		** Often long, but can even be coccoid
	** Lateral bulbar swellings		** Lateral bulbar swellings

Aidan: /* Clinical Manifestations */

2020-08-05T13:58:30Z

Clinical Manifestations

← Older revision		Revision as of 13:58, 5 August 2020
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	== Clinical Manifestations ==		== Clinical Manifestations ==
	* Incubation period 10 days (range 1 to 22 days)		* Incubation period [[Usual incubation period::10 days]] (range [[Incubation period range::1 to 22 days]])
	* Fever, chills, headache, nausea/vomiting, severe migratory arthralgias and myalgias		* Fever, chills, headache, nausea/vomiting, severe migratory arthralgias and myalgias
	** Wound has often healed by presentation		** Wound has often healed by presentation

Aidan: Text replacement - "== Clinical Presentation" to "== Clinical Manifestations"

2020-08-02T10:51:23Z

Text replacement - "== Clinical Presentation" to "== Clinical Manifestations"

← Older revision		Revision as of 10:51, 2 August 2020
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	* Autopsy shows erythrophagocytosis, hepatosplenomegaly, interstitial pneumonia, and lymph node sinus hyperplasia		* Autopsy shows erythrophagocytosis, hepatosplenomegaly, interstitial pneumonia, and lymph node sinus hyperplasia

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Incubation period 10 days (range 1 to 22 days)		* Incubation period 10 days (range 1 to 22 days)
	* Fever, chills, headache, nausea/vomiting, severe migratory arthralgias and myalgias		* Fever, chills, headache, nausea/vomiting, severe migratory arthralgias and myalgias

Aidan: Text replacement - " Stain::Gram" to " [[Stain::Gram"

2020-07-29T00:51:36Z

Text replacement - " Stain::Gram" to " [[Stain::Gram"

← Older revision		Revision as of 00:51, 29 July 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Pleomorphic, [[Has motility::non-motile]], non-sporulating, non-encapsulated filamentous Stain::Gram-negative]] [[Has cell shape::bacillus]]		* Pleomorphic, [[Has motility::non-motile]], non-sporulating, non-encapsulated filamentous [[Stain::Gram-negative]] [[Has cell shape::bacillus]]
	** Often long, but can even be coccoid		** Often long, but can even be coccoid
	** Lateral bulbar swellings		** Lateral bulbar swellings

Aidan: Text replacement - "[[Has Gram stain::" to "Stain::"

2020-07-05T19:44:56Z

Text replacement - "[[Has Gram stain::" to "Stain::"

← Older revision		Revision as of 19:44, 5 July 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Pleomorphic, [[Has motility::non-motile]], non-sporulating, non-encapsulated filamentous ~~[[Has Gram stain~~::Gram-negative]] [[Has cell shape::bacillus]]		* Pleomorphic, [[Has motility::non-motile]], non-sporulating, non-encapsulated filamentous Stain::Gram-negative]] [[Has cell shape::bacillus]]
	** Often long, but can even be coccoid		** Often long, but can even be coccoid
	** Lateral bulbar swellings		** Lateral bulbar swellings

Aidan at 15:01, 8 February 2020

2020-02-08T15:01:01Z

← Older revision		Revision as of 15:01, 8 February 2020
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	* Causes '''[[Causes ~~syndrome~~::rat-bite fever]]'''		* Causes '''[[Causes::rat-bite fever]]'''

	== Background ==		== Background ==

Aidan: /* Further Reading */ added section

2019-12-12T16:10:47Z

Aidan at 15:02, 24 October 2019

2019-10-24T15:02:32Z

← Older revision		Revision as of 15:02, 24 October 2019
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	* Causes '''[[rat-bite fever]]'''		* Causes '''[[Causes syndrome::rat-bite fever]]'''

	== Background ==		== Background ==

← Older revision		Revision as of 16:10, 12 December 2019
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	* Tetanus prophylaxis if appropriate		* Tetanus prophylaxis if appropriate
	* Can do 3 days of prophylactic penicillin 2 g daily divided		* Can do 3 days of prophylactic penicillin 2 g daily divided

			== Further Reading ==
			* Rat Bite Fever and ''Streptobacillus moniliformis''. ''Clin Microbiol Rev''. 2007;20(1):13-22. doi: [https://doi.org/10.1128/CMR.00016-06 10.1128/CMR.00016-06]


	{{DISPLAYTITLE:''Streptobacillus moniliformis''}}		{{DISPLAYTITLE:''Streptobacillus moniliformis''}}