Stenotrophomonas maltophilia - Revision history

Aidan: Text replacement - "[[Cellular shape::" to "[[Shape::"

2020-10-13T18:24:22Z

Text replacement - "[[Cellular shape::" to "[[Shape::"

← Older revision		Revision as of 18:24, 13 October 2020
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	===Microbiology===		===Microbiology===

	*Aerobic, non-fermentive, catalase [[Catalase::positive]], oxidase [[Oxidase::negative]], [[Stain::Gram-negative]] [[~~Cellular shape~~::bacillus]]		*Aerobic, non-fermentive, catalase [[Catalase::positive]], oxidase [[Oxidase::negative]], [[Stain::Gram-negative]] [[Shape::bacillus]]
	*Multiple mechanisms of resistance		*Multiple mechanisms of resistance
	**RND, MfsA, and Sme-related efflux pumps		**RND, MfsA, and Sme-related efflux pumps

Aidan: /* Microbiology */

2020-09-10T19:23:20Z

Microbiology

← Older revision		Revision as of 19:23, 10 September 2020
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	===Microbiology===		===Microbiology===

	*Aerobic, non-fermentive, catalase [[Catalase::positive]], oxidase-negative]], [[Stain::Gram ~~[[Oxidase::~~negative]] [[Cellular shape::bacillus]]		*Aerobic, non-fermentive, catalase [[Catalase::positive]], oxidase [[Oxidase::negative]], [[Stain::Gram-negative]] [[Cellular shape::bacillus]]
	*Multiple mechanisms of resistance		*Multiple mechanisms of resistance
	**RND, MfsA, and Sme-related efflux pumps		**RND, MfsA, and Sme-related efflux pumps

Aidan: Text replacement - "\[\[Oxidase test::(.?)-(.?)\]\]" to "$1 Oxidase::$2"

2020-08-20T19:54:43Z

Text replacement - "\[\[Oxidase test::(.*?)-(.*?)\]\]" to "$1 Oxidase::$2"

← Older revision		Revision as of 19:54, 20 August 2020
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	===Microbiology===		===Microbiology===

	*Aerobic, non-fermentive, catalase [[Catalase::positive]], ~~[[Oxidase test::~~oxidase-negative]], [[Stain::Gram-negative]] [[Cellular shape::bacillus]]		*Aerobic, non-fermentive, catalase [[Catalase::positive]], oxidase-negative]], [[Stain::Gram [[Oxidase::negative]] [[Cellular shape::bacillus]]
	*Multiple mechanisms of resistance		*Multiple mechanisms of resistance
	**RND, MfsA, and Sme-related efflux pumps		**RND, MfsA, and Sme-related efflux pumps

Aidan: Text replacement - "Catalase test::catalase-positive" to "catalase Catalase::positive"

2020-08-20T19:06:56Z

Text replacement - "Catalase test::catalase-positive" to "catalase Catalase::positive"

← Older revision		Revision as of 19:06, 20 August 2020
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	===Microbiology===		===Microbiology===

	*Aerobic, non-fermentive, [[Catalase ~~test~~::~~catalase-~~positive]], [[Oxidase test::oxidase-negative]], [[Stain::Gram-negative]] [[Cellular shape::bacillus]]		*Aerobic, non-fermentive, catalase [[Catalase::positive]], [[Oxidase test::oxidase-negative]], [[Stain::Gram-negative]] [[Cellular shape::bacillus]]
	*Multiple mechanisms of resistance		*Multiple mechanisms of resistance
	**RND, MfsA, and Sme-related efflux pumps		**RND, MfsA, and Sme-related efflux pumps

Aidan: /* Management */ added septra dose

2020-08-20T14:07:32Z

Management: added septra dose

← Older revision		Revision as of 14:07, 20 August 2020
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	*Therapy should be guided by antimicrobial susceptibility testing		*Therapy should be guided by antimicrobial susceptibility testing
	*Antistenotrophomonal antibiotics:		*Antistenotrophomonal antibiotics:
	**[[Is treated by::TMP-SMX]] (preferred agent, if susceptible)		**[[Is treated by::TMP-SMX]] 15 mg/kg split q8h (preferred agent, if susceptible)
	**[[Is treated by::Fluoroquinolones]], including [[Is treated by::moxifloxacin]], [[Is treated by::levofloxacin]], and [[Is treated by::ciprofloxacin]] (though develops resistance quickly on monotherapy)		**[[Is treated by::Fluoroquinolones]], including [[Is treated by::moxifloxacin]], [[Is treated by::levofloxacin]], and [[Is treated by::ciprofloxacin]] (though develops resistance quickly on monotherapy)
	**[[Is treated by::Minocycline]], [[Is treated by::doxycycline]], and [[Is treated by::tigecycline]]		**[[Is treated by::Minocycline]], [[Is treated by::doxycycline]], and [[Is treated by::tigecycline]]

Aidan: /* Management */

2020-08-17T01:38:35Z

Management

← Older revision		Revision as of 01:38, 17 August 2020
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	**[[Is treated by::Ticarcillin-clavulanate]] and [[Is treated by::ampicillin-sulbactam]]		**[[Is treated by::Ticarcillin-clavulanate]] and [[Is treated by::ampicillin-sulbactam]]
	**[[Is treated by::Ceftazidime]] and [[Is treated by::ceftazidime-avibactam]]		**[[Is treated by::Ceftazidime]] and [[Is treated by::ceftazidime-avibactam]]
	**[[Is treated by::Colistin]]		**[[Is treated by::Colistin]], though high rates of resistance
	**Possibly [[Is treated by::ceftriaxone]]		**Possibly [[Is treated by::ceftriaxone]]

Aidan: /* Management */

2020-08-17T01:38:00Z

Management

← Older revision		Revision as of 01:38, 17 August 2020
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	**[[Is treated by::Ticarcillin-clavulanate]] and [[Is treated by::ampicillin-sulbactam]]		**[[Is treated by::Ticarcillin-clavulanate]] and [[Is treated by::ampicillin-sulbactam]]
	**[[Is treated by::Ceftazidime]] and [[Is treated by::ceftazidime-avibactam]]		**[[Is treated by::Ceftazidime]] and [[Is treated by::ceftazidime-avibactam]]
			**[[Is treated by::Colistin]]
	**Possibly [[Is treated by::ceftriaxone]]		**Possibly [[Is treated by::ceftriaxone]]

Aidan: /* Management */

2020-08-17T01:36:54Z

Management

← Older revision		Revision as of 01:36, 17 August 2020
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	*Therapy should be guided by antimicrobial susceptibility testing		*Therapy should be guided by antimicrobial susceptibility testing
	*Antistenotrophomonal antibiotics:		*Antistenotrophomonal antibiotics:
	**[[TMP-SMX]] (preferred agent, if susceptible)		**[[Is treated by::TMP-SMX]] (preferred agent, if susceptible)
	**[[Fluoroquinolones]], including [[moxifloxacin]], [[levofloxacin]], and [[ciprofloxacin]] (though develops resistance quickly on monotherapy)		**[[Is treated by::Fluoroquinolones]], including [[Is treated by::moxifloxacin]], [[Is treated by::levofloxacin]], and [[Is treated by::ciprofloxacin]] (though develops resistance quickly on monotherapy)
	**[[Minocycline]], [[doxycycline]], and [[tigecycline]]		**[[Is treated by::Minocycline]], [[Is treated by::doxycycline]], and [[Is treated by::tigecycline]]
	**[[Ticarcillin-clavulanate]] and [[ampicillin-sulbactam]]		**[[Is treated by::Ticarcillin-clavulanate]] and [[Is treated by::ampicillin-sulbactam]]
	**[[~~ceftazidime~~]] and [[ceftazidime-avibactam]]		**[[Is treated by::Ceftazidime]] and [[Is treated by::ceftazidime-avibactam]]
	**Possibly [[ceftriaxone]]		**Possibly [[Is treated by::ceftriaxone]]

	{{DISPLAYTITLE:''Stenotrophomonas maltophilia''}}		{{DISPLAYTITLE:''Stenotrophomonas maltophilia''}}

Aidan: /* Management */

2020-08-17T01:36:11Z

Management

← Older revision		Revision as of 01:36, 17 August 2020
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	== Background ==		==Background==

	===Microbiology===		===Microbiology===
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	*Multiple mechanisms of resistance		*Multiple mechanisms of resistance
	**RND, MfsA, and Sme-related efflux pumps		**RND, MfsA, and Sme-related efflux pumps
	**''Sul'' or ''dfrA'' genes (TMP-SMX resistance)		**''Sul'' or ''dfrA'' genes (TMP-SMX resistance)
	**β-lactamases		**β-lactamases
	**Aminoglycoside-modifying enzymes		**Aminoglycoside-modifying enzymes
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	*Antistenotrophomonal antibiotics:		*Antistenotrophomonal antibiotics:
	**[[TMP-SMX]] (preferred agent, if susceptible)		**[[TMP-SMX]] (preferred agent, if susceptible)
	**[[Fluoroquinolones]], including [[moxifloxacin]], [[levofloxacin]], and [[ciprofloxacin]] (though develops resistance quickly on monotherapy)		**[[Fluoroquinolones]], including [[moxifloxacin]], [[levofloxacin]], and [[ciprofloxacin]] (though develops resistance quickly on monotherapy)
	**[[Minocycline]], [[doxycycline]], and [[tigecycline]]		**[[Minocycline]], [[doxycycline]], and [[tigecycline]]
	**[[Ticarcillin-clavulanate]] and [[ampicillin-sulbactam]]		**[[Ticarcillin-clavulanate]] and [[ampicillin-sulbactam]]

Aidan: /* Management */

2020-08-15T15:14:30Z

Management

← Older revision		Revision as of 15:14, 15 August 2020
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	== ~~Microbiology~~ ==		== Background ==

			===Microbiology===
	* Aerobic, non-fermentive, Gram negative, catalase positive, oxidase negative

			*Aerobic, non-fermentive, [[Catalase test::catalase-positive]], [[Oxidase test::oxidase-negative]], [[Stain::Gram-negative]] [[Cellular shape::bacillus]]
⚫	== Clinical Manifestations ==
			*Multiple mechanisms of resistance
			**RND, MfsA, and Sme-related efflux pumps
			**''Sul'' or ''dfrA'' genes (TMP-SMX resistance)
			**β-lactamases
			**Aminoglycoside-modifying enzymes

		⚫	==Clinical Manifestations==
⚫	* Nosocomial infections with high mortality and high antibiotic resistance

		⚫	*Nosocomial infections with high mortality and high antibiotic resistance
⚫	== Management ==

		⚫	==Management==
⚫	* Limited antibiotic options:

	** [[Levofloxacin]] (and other FQs)
		⚫	*Limited antibiotic options
	** [[TMP-SMX]] (Septra)
			*Therapy should be guided by antimicrobial susceptibility testing
	** [[Doxycycline]]
			*Antistenotrophomonal antibiotics:
	** Maybe also ticarcillin-clavulanate and [[ceftazidime]]
			**[[TMP-SMX]] (preferred agent, if susceptible)
			**[[Fluoroquinolones]], including [[moxifloxacin]], [[levofloxacin]], and [[ciprofloxacin]] (though develops resistance quickly on monotherapy)
			**[[Minocycline]], [[doxycycline]], and [[tigecycline]]
			**[[Ticarcillin-clavulanate]] and [[ampicillin-sulbactam]]
			**[[ceftazidime]] and [[ceftazidime-avibactam]]
			**Possibly [[ceftriaxone]]

	{{DISPLAYTITLE:''Stenotrophomonas maltophilia''}}		{{DISPLAYTITLE:''Stenotrophomonas maltophilia''}}

Stenotrophomonas maltophilia - Revision history

Aidan: Text replacement - "[[Cellular shape::" to "[[Shape::"

Aidan: /* Microbiology */

Aidan: Text replacement - "\[\[Oxidase test::(.*?)-(.*?)\]\]" to "$1 Oxidase::$2"

Aidan: Text replacement - "Catalase test::catalase-positive" to "catalase Catalase::positive"

Aidan: /* Management */ added septra dose

Aidan: /* Management */

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Aidan: Text replacement - "\[\[Oxidase test::(.?)-(.?)\]\]" to "$1 Oxidase::$2"