Aidan: Created page with "== Background == * Potentially life-threatening adverse drug reaction with significant skin involvement == Comparison == * From CiteRef::duong2017se {| class="wikitable" !SCAR !Time to Onset !Skin Findings !Other Symptoms !Investigations !Histology |- |SJS/TEN |4 to 28 days |Blisters, large areas of skin detachment, confluent erythema, atypical target lesions, purpura, Nikolsky sign |Flu-like febrile illness and respiratory symptoms |Lymphopenia, tran..."

2026-01-07T00:18:35Z

Created page with "== Background == * Potentially life-threatening adverse drug reaction with significant skin involvement == Comparison == * From CiteRef::duong2017se {| class="wikitable" !SCAR !Time to Onset !Skin Findings !Other Symptoms !Investigations !Histology |- |SJS/TEN |4 to 28 days |Blisters, large areas of skin detachment, confluent erythema, atypical target lesions, purpura, Nikolsky sign |Flu-like febrile illness and respiratory symptoms |Lymphopenia, tran..."

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== Background ==

* Potentially life-threatening [[adverse drug reaction]] with significant skin involvement

== Comparison ==

* From [[CiteRef::duong2017se]]

{| class="wikitable"
!SCAR
!Time to Onset
!Skin Findings
!Other Symptoms
!Investigations
!Histology
|-
|[[SJS]]/[[TEN]]
|4 to 28 days
|Blisters, large areas of skin detachment, confluent erythema, atypical target lesions, purpura, Nikolsky sign
|Flu-like febrile illness and respiratory symptoms
|Lymphopenia, transitory neutropenia, mild cytolysis, AKI
|Full-thickness epidermal necrosis, focal adnexal necrosis, necrotic keratinocytes, mild mononuclear cell dermal infiltrate, negative direct immunofluorescence test
|-
|[[DRESS]]
|2 to 6 weeks
|Maculopapular rash, erythroderma, edema of face and extremities, purpura, pustules, focal monopolar mucous membrane involvement
|Flu-like febrile illness
|Eosinophilia, atypical lymphocytes, ALT, AKI, herpesvirus or parvovirus reactivation
|Lichenoid infiltrate or eczematous pattern (spongiosis, oedema), focal necrotic keratinocytes, mononuclear infiltrate, focal eosinophil and neutrophil infiltrates, mild vasculitis
|-
|[[AGEP]]
|1 to 11 days
|Intertriginous erythema, edema, widespread sterile pustules, post-pustular pinpoint desquamation, Nikosky sign, rare oral mucosal involvement
|Fever
|Leukocytosis, neutrophilis, mild eosinophilia
|Subcorneal or intraepidermal spongiform or non-spongiform pustules with or without papillary oedema, focal necrotic keratinocytes, neutrophilic sometimes with eosinophils, mild vasculitis
|}

== Further Reading ==

* Severe cutaneous adverse reactions to drugs. ''Lancet''. 2017 Oct 28;390(10106):1996-2011. doi: [https://doi.org/10.1016/S0140-6736(16)30378-6 10.1016/S0140-6736(16)30378-6].

[[Category:Dermatology]]
[[Category:Adverse drug reactions]]

Severe cutaneous adverse reaction - Revision history