Scedosporium - Revision history

Aidan: /* Management */

2024-06-18T19:34:11Z

Management

← Older revision		Revision as of 19:34, 18 June 2024
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	== Management ==		== Management ==
	* ''S. apiopsermum'' is treated with voriconazole or amphotericin B		* ''S. apiopsermum'' is treated with [[voriconazole]] or [[amphotericin B]]
	* However, ''S. prolificans'' is extremely resistant to antifungals including amphotericin		* However, ''S. prolificans'' is extremely resistant to antifungals including [[amphotericin]]

	== Further Reading ==		== Further Reading ==

Aidan at 20:49, 12 February 2022

2022-02-12T20:49:21Z

← Older revision		Revision as of 20:49, 12 February 2022
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	* ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: ''Fusarium'' spp., ''Scedosporium'' spp. and others. ''Clin Micro Inf''. 2014 20(Suppl 3):27-46. [https://doi.org/10.1111/1469-0691.12465 10.1111/1469-0691.12465]		* ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: ''Fusarium'' spp., ''Scedosporium'' spp. and others. ''Clin Micro Inf''. 2014 20(Suppl 3):27-46. [https://doi.org/10.1111/1469-0691.12465 10.1111/1469-0691.12465]

	{{DISPLAYTITLE:''Scedosporium'' ~~species~~}}		{{DISPLAYTITLE:''Scedosporium''}}
	[[Category:Hyaline molds]]		[[Category:Hyaline molds]]

Aidan: Aidan moved page Scedosporium species to Scedosporium over redirect: Text replacement - " species" to ""

2022-01-30T04:42:31Z

Aidan moved page Scedosporium species to Scedosporium over redirect: Text replacement - " species" to ""

← Older revision		Revision as of 04:42, 30 January 2022
(No difference)

Aidan: Text replacement - "== Clinical Presentation" to "== Clinical Manifestations"

2020-08-02T12:11:15Z

Text replacement - "== Clinical Presentation" to "== Clinical Manifestations"

← Older revision		Revision as of 12:11, 2 August 2020
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	* Affects primarily the immunocompromised, though can cause localized infections in immunocompetent as well		* Affects primarily the immunocompromised, though can cause localized infections in immunocompetent as well

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Colonization of airways, especially in bronchiectasis		* Colonization of airways, especially in bronchiectasis
	* ''Pseudallescheria boydii'' (''Scedosporium apiospermum'') can cause mycetoma, and also pseudallescheriasis/scedosporiosis of lung, bone, joint, CNS. Rare sites of involvement include sinusitis, keratitis, endophthalmitis, skin and soft tissue infections, prostatitis, and endocarditis.		* ''Pseudallescheria boydii'' (''Scedosporium apiospermum'') can cause mycetoma, and also pseudallescheriasis/scedosporiosis of lung, bone, joint, CNS. Rare sites of involvement include sinusitis, keratitis, endophthalmitis, skin and soft tissue infections, prostatitis, and endocarditis.

Aidan: Added further reading

2019-11-02T19:59:46Z

Added further reading

← Older revision		Revision as of 19:59, 2 November 2019
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	* ''S. apiopsermum'' is treated with voriconazole or amphotericin B		* ''S. apiopsermum'' is treated with voriconazole or amphotericin B
	* However, ''S. prolificans'' is extremely resistant to antifungals including amphotericin		* However, ''S. prolificans'' is extremely resistant to antifungals including amphotericin

			== Further Reading ==
			* ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: ''Fusarium'' spp., ''Scedosporium'' spp. and others. ''Clin Micro Inf''. 2014 20(Suppl 3):27-46. [https://doi.org/10.1111/1469-0691.12465 10.1111/1469-0691.12465]

	{{DISPLAYTITLE:''Scedosporium'' species}}		{{DISPLAYTITLE:''Scedosporium'' species}}

Aidan: Initial

2019-11-02T19:58:37Z

Initial

← Older revision		Revision as of 19:58, 2 November 2019
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	== ~~Microbiology~~ ==		== Background ==
			=== Microbiology ===

	* Septate hyaline mold		* Septate hyaline mold
	* Macroscopic appearance		* Macroscopic appearance
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	** Brown '''cleistothecia''' may be present after 2-3 weeks of incubation (looks like a Pacman vomiting out conidia)		** Brown '''cleistothecia''' may be present after 2-3 weeks of incubation (looks like a Pacman vomiting out conidia)

	== Epidemiology ==		=== Epidemiology ===

	* Found in rural soils, polluted waters, compost, cattle manure, and bird poop, as well as colonizing the respiratory tract		* Found in rural soils, polluted waters, compost, cattle manure, and bird poop, as well as colonizing the respiratory tract
	* Present worldwide		* Present worldwide
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	== Clinical Presentation ==		== Clinical Presentation ==

	* Colonization of airways, especially in bronchiectasis		* Colonization of airways, especially in bronchiectasis
	* ''Pseudallescheria boydii'' (''Scedosporium ~~apiospermum~~'') can cause mycetoma, and also pseudallescheriasis/scedosporiosis of lung, bone, joint, CNS. Rare sites of involvement include sinusitis, keratitis, endophthalmitis, skin and soft tissue infections, prostatitis, and endocarditis.		* ''Pseudallescheria boydii'' (''Scedosporium apiospermum'') can cause mycetoma, and also pseudallescheriasis/scedosporiosis of lung, bone, joint, CNS. Rare sites of involvement include sinusitis, keratitis, endophthalmitis, skin and soft tissue infections, prostatitis, and endocarditis.
	* ''Scedosporium prolificans'' usually causes localized infections in immunocompetent patients (bone and joint, eye, wounds, onychomycosis). In immunocompromised patients (e.g. neutropenia from chemotherapy), can disseminate and involve skin, lung, muscle, endophthalmitis		* ''Scedosporium prolificans'' usually causes localized infections in immunocompetent patients (bone and joint, eye, wounds, onychomycosis). In immunocompromised patients (e.g. neutropenia from chemotherapy), can disseminate and involve skin, lung, muscle, endophthalmitis
			** In immunocompetent hosts, includes keratitis, endophthalmitis, otitis, sinusitis, central nervous system infections, osteoarticular and soft tissue infections and pneumonia after near drowning
			*** CNS disease may occur from contiguous spread from sinuses, penetrating trauma, or pulmonary infection from near-drowning
			** In immunosuppressed hosts, deep-seated infections can involve any organ with a predilection for skin, sinuses, lungs and central nervous system (typically following hematogenous dissemination)
			** In cystic fibrosis, can be colonizer and also cause infection

	== Diagnosis ==		== Diagnosis ==
		⚫	* With culture, though may represent colonization if recovered from a respiratory specimen

			** Microscopy
⚫	* With culture, though may represent colonization if recovered from a respiratory specimen.
			*** Both have septate, branching, hyaline hyphae with simple or branched annellide conidiophores, often annellide
			*** May have ''Graphium'' state
			*** The conidial states are morphologically indistinguishable
			*** Species may be differentiated by physiological tests or by the presence of cleistothecia (for ''P. boydii'')
			** Teleomorphs
			** ''Scedosporium boydii'' (teleomorphic state, ''Pseudallescheria boydii''): Contains brown cleistothecia after 2-3 weeks of incubation that, when crushed, release ascospores
			** ''Scedosporium apiospermum'' (teleomorphic state, ''Pseudallescheria apiosperma'')

	== Management ==		== Management ==
			* ''S. apiopsermum'' is treated with voriconazole or amphotericin B

	* ~~''S. apiopsermum'' is treated with voriconazole or amphotericin B.~~ However, ''S. prolificans'' is extremely resistant to antifungals including amphotericin		* However, ''S. prolificans'' is extremely resistant to antifungals including amphotericin


	{{DISPLAYTITLE:''Scedosporium'' species}}		{{DISPLAYTITLE:''Scedosporium'' species}}

Aidan at 16:56, 23 August 2019

2019-08-23T16:56:44Z

← Older revision		Revision as of 16:56, 23 August 2019
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	* Present worldwide		* Present worldwide
	* Affects primarily the immunocompromised, though can cause localized infections in immunocompetent as well		* Affects primarily the immunocompromised, though can cause localized infections in immunocompetent as well


	== Clinical Presentation ==		== Clinical Presentation ==

Aidan at 16:56, 23 August 2019

2019-08-23T16:56:35Z

← Older revision		Revision as of 16:56, 23 August 2019
Line 9:		Line 9:
	** Sometimes has a '''''Graphium'' state''' where conidiophores are bound together		** Sometimes has a '''''Graphium'' state''' where conidiophores are bound together
	** Brown '''cleistothecia''' may be present after 2-3 weeks of incubation (looks like a Pacman vomiting out conidia)		** Brown '''cleistothecia''' may be present after 2-3 weeks of incubation (looks like a Pacman vomiting out conidia)


	== Epidemiology ==		== Epidemiology ==

Aidan: Initial page creation, split from 'Hyaline molds'

2019-08-23T16:56:09Z

Initial page creation, split from 'Hyaline molds'

New page

== Microbiology ==

* Septate hyaline mold
* Macroscopic appearance
** Colony grows rapidly, with wooly to cottony texture, a white surface that browns as it ages, and a pale reverse with brownish black zones.
* Microscopic appearance
** Septate, hyaline hyphae with annellide conidiophores that are simple or branched
** Onidia are unicellular, obovoid, and pale brown
** Sometimes has a '''''Graphium'' state''' where conidiophores are bound together
** Brown '''cleistothecia''' may be present after 2-3 weeks of incubation (looks like a Pacman vomiting out conidia)

== Epidemiology ==

* Found in rural soils, polluted waters, compost, cattle manure, and bird poop, as well as colonizing the respiratory tract
* Present worldwide
* Affects primarily the immunocompromised, though can cause localized infections in immunocompetent as well

== Clinical Presentation ==

* Colonization of airways, especially in bronchiectasis
* ''Pseudallescheria boydii'' (''Scedosporium apiospermum'') can cause mycetoma, and also pseudallescheriasis/scedosporiosis of lung, bone, joint, CNS. Rare sites of involvement include sinusitis, keratitis, endophthalmitis, skin and soft tissue infections, prostatitis, and endocarditis.
* ''Scedosporium prolificans'' usually causes localized infections in immunocompetent patients (bone and joint, eye, wounds, onychomycosis). In immunocompromised patients (e.g. neutropenia from chemotherapy), can disseminate and involve skin, lung, muscle, endophthalmitis

== Diagnosis ==

* With culture, though may represent colonization if recovered from a respiratory specimen.

== Management ==

* ''S. apiopsermum'' is treated with voriconazole or amphotericin B. However, ''S. prolificans'' is extremely resistant to antifungals including amphotericin

{{DISPLAYTITLE:''Scedosporium'' species}}
[[Category:Hyaline molds]]