SPICE organisms - Revision history

Aidan at 19:54, 7 February 2025

2025-02-07T19:54:36Z

← Older revision		Revision as of 19:54, 7 February 2025
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	**[[Carbapenems]] still work, as do [[aminoglycosides]]		**[[Carbapenems]] still work, as do [[aminoglycosides]]
	**[[Cefipime]] still works when MIC ≤2 mcg/mL		**[[Cefipime]] still works when MIC ≤2 mcg/mL
	*For [[Serratia marcescens]], [[Morganella morganii]], ~~and~~ [[Providencia]], treat based on susceptibility testing		*For [[Serratia marcescens]], [[Morganella morganii]], [[Providencia]], and [[Proteus]] treat based on susceptibility testing
	*Less data for [[Hafnia alvei]], [[Citrobacter youngae]], and [[Yersinia enterocolitica]], but reasonable to treat based on susceptibility testing		*Less data for [[Hafnia alvei]], [[Citrobacter youngae]], and [[Yersinia enterocolitica]], but reasonable to treat based on susceptibility testing

Aidan: /* Organisms */

2024-10-25T14:44:48Z

Organisms

← Older revision		Revision as of 14:44, 25 October 2024
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	** [[Citrobacter koseri]] does ''not'' have an AmpC		** [[Citrobacter koseri]] does ''not'' have an AmpC
	* [[Enterobacter cloacae\|'''Enterobacter cloacae''']], and now also '''[[Klebsiella aerogenes]]''' (previously ''Enterobacter aerogenes'')		* [[Enterobacter cloacae\|'''Enterobacter cloacae''']], and now also '''[[Klebsiella aerogenes]]''' (previously ''Enterobacter aerogenes'')
			* And maybe also:

			** [[Hafnia alvei]]
	Also:
			** [[Morganella morganii]]

	* [[~~Hafnia alvei~~]]		** [[Cronobacter]]
	* [[~~Morganella morganii~~]]		** [[Edwardsiella]]
	* [[Cronobacter]]
	* [[Edwardsiella]]

	== Management ==		== Management ==

Aidan at 17:42, 4 September 2024

2024-09-04T17:42:54Z

← Older revision		Revision as of 17:42, 4 September 2024
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	* Indole-positive [[Proteus]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])		* Indole-positive [[Proteus]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])
	* [[Citrobacter\|'''Citrobacter''']]		* [[Citrobacter\|'''Citrobacter''']]
	** [[C. koseri]] does ''not'' have an AmpC		** [[Citrobacter koseri]] does ''not'' have an AmpC
	* [[Enterobacter cloacae\|'''Enterobacter cloacae''']], and now also '''[[Klebsiella aerogenes]]''' (previously ''Enterobacter aerogenes'')		* [[Enterobacter cloacae\|'''Enterobacter cloacae''']], and now also '''[[Klebsiella aerogenes]]''' (previously ''Enterobacter aerogenes'')

Aidan: /* Organisms */

2023-10-26T17:57:51Z

Organisms

← Older revision		Revision as of 17:57, 26 October 2023
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	* [[Hafnia alvei]]		* [[Hafnia alvei]]
	* [[Acinetobacter]], though not inducible or AmpC (merely very resistant_
	* [[Morganella morganii]]		* [[Morganella morganii]]
	* [[Cronobacter]]		* [[Cronobacter]]

Aidan: /* Organisms */

2023-10-26T17:55:21Z

Organisms

← Older revision		Revision as of 17:55, 26 October 2023
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	* [[Providencia]]		* [[Providencia]]
	* Indole-positive [[Proteus]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])		* Indole-positive [[Proteus]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])
	* [[Citrobacter ~~species~~\|'''Citrobacter ~~species~~''']]		* [[Citrobacter\|'''Citrobacter''']]
	** [[C. koseri]] does ''not'' have an AmpC		** [[C. koseri]] does ''not'' have an AmpC
	* [[Enterobacter cloacae\|'''Enterobacter cloacae''']], and now also '''[[Klebsiella aerogenes]]''' (previously ''Enterobacter aerogenes'')		* [[Enterobacter cloacae\|'''Enterobacter cloacae''']], and now also '''[[Klebsiella aerogenes]]''' (previously ''Enterobacter aerogenes'')

Aidan: Text replacement - " species]]" to "]]"

2022-02-08T02:47:25Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 02:47, 8 February 2022
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	== Organisms ==		== Organisms ==

	* [[Serratia ~~species~~]]		* [[Serratia]]
	* [[Providencia]]		* [[Providencia]]
	* Indole-positive [[Proteus ~~species~~]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])		* Indole-positive [[Proteus]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])
	* [[Citrobacter species\|'''Citrobacter species''']]		* [[Citrobacter species\|'''Citrobacter species''']]
	** [[C. koseri]] does ''not'' have an AmpC		** [[C. koseri]] does ''not'' have an AmpC

Aidan at 20:08, 24 November 2021

2021-11-24T20:08:24Z

← Older revision		Revision as of 20:08, 24 November 2021
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	== ~~Definition~~ ==		== Background ==

	* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily [[AmpC β-lactamase]]		* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily [[AmpC β-lactamase]]
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	* [[Edwardsiella]]		* [[Edwardsiella]]

	== ~~Treatment~~ ==		== Management ==

			* For [[Enterobacter cloacae]], [[Klebsiella aerogenes]], and [[Citrobacter freundii]], avoid all penicillins and cephalosporins regardless of susceptibility testing
	* ''Not'' penicillins or cephalosporins, as resistance will develop within a few days
	* Carbapenems still work, as do aminoglycosides		**[[Carbapenems]] still work, as do [[aminoglycosides]]
			**[[Cefipime]] still works when MIC ≤2 mcg/mL
			*For [[Serratia marcescens]], [[Morganella morganii]], and [[Providencia]], treat based on susceptibility testing
			*Less data for [[Hafnia alvei]], [[Citrobacter youngae]], and [[Yersinia enterocolitica]], but reasonable to treat based on susceptibility testing

	== Further Reading ==		== Further Reading ==

Aidan at 19:59, 24 November 2021

2021-11-24T19:59:42Z

← Older revision		Revision as of 19:59, 24 November 2021
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	== Definition ==		== Definition ==

	* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily ~~chromosomal~~ AmpC		* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily [[AmpC β-lactamase]]

	== Organisms ==		== Organisms ==
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	* [[Providencia]]		* [[Providencia]]
	* Indole-positive [[Proteus species]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])		* Indole-positive [[Proteus species]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])
	* [[Citrobacter species]]		* [[Citrobacter species\|'''Citrobacter species''']]
	** [[C. koseri]] does ''not'' have an AmpC		** [[C. koseri]] does ''not'' have an AmpC
			* [[Enterobacter cloacae\|'''Enterobacter cloacae''']], and now also '''[[Klebsiella aerogenes]]''' (previously ''Enterobacter aerogenes'')
	* [[Enterobacter cloacae]]

	Also:		Also:

Aidan: /* Organisms */ linkified

2019-09-28T20:33:18Z

Organisms: linkified

← Older revision		Revision as of 20:33, 28 September 2019
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	== Organisms ==		== Organisms ==

	* ''Serratia'' ~~spp.~~		* [[Serratia species]]
	* ''Providencia''		* [[Providencia]]
	* Indole-positive ~~''Proteae''~~ (e.g. ''Proteus vulgaris'', but not ''Proteus mirabilis'')		* Indole-positive [[Proteus species]] (e.g. [[Proteus vulgaris]], but not [[Proteus mirabilis]])
	* ''Citrobacter'' ~~spp.~~		* [[Citrobacter species]]
	** ''C. koseri'' does ''not'' have an AmpC		** [[C. koseri]] does ''not'' have an AmpC
	* ''Enterobacter cloacae''		* [[Enterobacter cloacae]]

	Also:		Also:

	* ''Hafnia alvei''		* [[Hafnia alvei]]
	* ''Acinetobacter'', though not inducible or AmpC (merely very resistant_		* [[Acinetobacter]], though not inducible or AmpC (merely very resistant_
	* ''Morganella morganii''		* [[Morganella morganii]]
	* ''Cronobacter''		* [[Cronobacter]]
	* ''Edwardsiella''		* [[Edwardsiella]]

	== Treatment ==		== Treatment ==

Aidan at 12:50, 16 August 2019

2019-08-16T12:50:15Z

← Older revision		Revision as of 12:50, 16 August 2019
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	= Definition =		== Definition ==

	* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC		* Gram-negative bacteria with inducible or derepressable beta-lactamases, primarily chromosomal AmpC

	= Organisms =		== Organisms ==

	* ''Serratia'' spp.		* ''Serratia'' spp.
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	* ''Edwardsiella''		* ''Edwardsiella''

	= Treatment =		== Treatment ==

	* ''Not'' penicillins or cephalosporins, as resistance will develop within a few days		* ''Not'' penicillins or cephalosporins, as resistance will develop within a few days
	* Carbapenems still work, as do aminoglycosides		* Carbapenems still work, as do aminoglycosides

	= Further Reading =		== Further Reading ==

	* Jones R, Baquero F, Privitera G, Inoue M, Widermann B. [https://doi.org/10.1111/j.1469-0691.1997.tb00643.x Inducible β-lactamase-mediated resistance to third-generation cephalosporins]. ''Clin Microbio Infect''. 1997;3(1):S7-S20.		* Jones R, Baquero F, Privitera G, Inoue M, Widermann B. [https://doi.org/10.1111/j.1469-0691.1997.tb00643.x Inducible β-lactamase-mediated resistance to third-generation cephalosporins]. ''Clin Microbio Infect''. 1997;3(1):S7-S20.