Rifampin - Revision history

Aidan at 14:13, 23 September 2024

2024-09-23T14:13:03Z

← Older revision		Revision as of 14:13, 23 September 2024
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	* [[Adverse drug reaction::drug-drug interactions\|Drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]]		* [[Adverse drug reaction::drug-drug interactions\|Drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]]
	* Drug-drug interactions		* Drug-drug interactions
	* Flu-like syndrome~~<ref>Dhhar G, McColl J, Kitai I, Levy DM, Verstegen RHJ. Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection. <abbr>''CMAJ.''</abbr> 2023;195(34):E1151-E1153. DOI:~~ [~~https~~:~~//doi.org/10.1503/cmaj.230317 10.1503/cmaj.230317~~]~~</ref>~~, a type III [[hypersensitivity reaction]] characterized by fevers, chills, myalgias, and arthalgias usually 1-4 hours (but up to 12 hours) after a dose, and lasts for 8 hours; if rechallenged, can develop hypotension and shock		* Flu-like syndrome[[CiteRef::dhhar2023ri]], a type III [[hypersensitivity reaction]] characterized by fevers, chills, myalgias, and arthalgias usually 1-4 hours (but up to 12 hours) after a dose, and lasts for 8 hours; if rechallenged, can develop hypotension and shock

	=== Drug-Drug Interactions ===		=== Drug-Drug Interactions ===

Aidan: /* Drug-Drug Interactions */ added CYPs induced by rif

2024-09-23T14:12:25Z

Drug-Drug Interactions: added CYPs induced by rif

← Older revision		Revision as of 14:12, 23 September 2024
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	* Multiple		* Multiple
			* Induces [[Induces::CYP2B6]], [[Induces::CYP2C8]], [[Induces::CYP2C9]], [[Induces::CYP2C19]], [[Induces::CYP2D6]], and [[Induces::CYP3A]]
	* Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]]		* Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]]

Aidan at 17:29, 10 December 2023

2023-12-10T17:29:46Z

← Older revision		Revision as of 17:29, 10 December 2023
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			== Background ==
	* Inhibits bacterial DNA-dependent RNA polymerase		* Inhibits bacterial DNA-dependent RNA polymerase
	* Never given alone due to rapid resistance		* Never given alone due to rapid resistance
⚫	* ~~Adverse effects include~~ [[Adverse drug reaction::drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]]
⚫	* Avoid in liver failure

	== Dosing ==		== Dosing ==
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	== Safety ==		== Safety ==

		⚫	* '''Avoid in liver failure'''

			=== Adverse Effects ===

			* Orange or red discoloration of body fluids
		⚫	* [[Adverse drug reaction::drug-drug interactions\|Drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]]
			* Drug-drug interactions
			* Flu-like syndrome<ref>Dhhar G, McColl J, Kitai I, Levy DM, Verstegen RHJ. Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection. <abbr>''CMAJ.''</abbr> 2023;195(34):E1151-E1153. DOI: [https://doi.org/10.1503/cmaj.230317 10.1503/cmaj.230317]</ref>, a type III [[hypersensitivity reaction]] characterized by fevers, chills, myalgias, and arthalgias usually 1-4 hours (but up to 12 hours) after a dose, and lasts for 8 hours; if rechallenged, can develop hypotension and shock

	=== Drug-Drug Interactions ===		=== Drug-Drug Interactions ===

Aidan at 02:12, 23 October 2022

2022-10-23T02:12:27Z

← Older revision		Revision as of 02:12, 23 October 2022
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	** Weight <60 kg: 600 mg p.o. daily		** Weight <60 kg: 600 mg p.o. daily
	** Weight >60 kg: 450 mg p.o. twice daily		** Weight >60 kg: 450 mg p.o. twice daily

			== Safety ==

			=== Drug-Drug Interactions ===

			* Multiple
			* Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]]

	[[Category:Rifamycins]]		[[Category:Rifamycins]]

Aidan at 20:29, 30 August 2022

2022-08-30T20:29:53Z

← Older revision		Revision as of 20:29, 30 August 2022
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	* Adverse effects include [[Adverse drug reaction::drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]]		* Adverse effects include [[Adverse drug reaction::drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]]
	* Avoid in liver failure		* Avoid in liver failure

			== Dosing ==

			* As adjunct to fluoroquinolone for [[Staphylococcus aureus]]:
			** Weight <60 kg: 600 mg p.o. daily
			** Weight >60 kg: 450 mg p.o. twice daily

	[[Category:Rifamycins]]		[[Category:Rifamycins]]

Aidan at 03:18, 18 February 2020

2020-02-18T03:18:25Z

← Older revision		Revision as of 03:18, 18 February 2020
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	* Inhibits bacterial DNA-dependent RNA polymerase		* Inhibits bacterial DNA-dependent RNA polymerase
	* Never given alone due to rapid resistance		* Never given alone due to rapid resistance
	* Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia		* Adverse effects include [[Adverse drug reaction::drug-drug interactions]], [[Adverse drug reaction::rash]], [[Adverse drug reaction::hepatitis]], [[Adverse drug reaction::influenza-like illness]], [[Adverse drug reaction::neutropenia]], and [[Adverse drug reaction::thrombocytopenia]]
	* Avoid in liver failure		* Avoid in liver failure

Aidan at 03:08, 14 November 2019

2019-11-14T03:08:40Z

← Older revision		Revision as of 03:08, 14 November 2019
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			* Inhibits bacterial DNA-dependent RNA polymerase
	* Never given alone due to rapid resistance		* Never given alone due to rapid resistance
			* Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
	* Beware drug interactions
	* Avoid in liver failure		* Avoid in liver failure

Aidan at 10:52, 12 August 2019

2019-08-12T10:52:27Z

← Older revision		Revision as of 10:52, 12 August 2019
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	* Beware drug interactions		* Beware drug interactions
	* Avoid in liver failure		* Avoid in liver failure

			[[Category:Rifamycins]]

Aidan: /* Rifampin */

2019-08-12T10:51:08Z

Rifampin

← Older revision		Revision as of 10:51, 12 August 2019
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	= Rifampin =

	* Never given alone due to rapid resistance		* Never given alone due to rapid resistance
	* Beware drug interactions		* Beware drug interactions
	* ~~Near use~~ in liver? ~~Failure~~		* Avoid in liver failure

Maintenance script: Imported from text file

2019-08-11T17:58:22Z

Imported from text file

New page

= Rifampin =

* Never given alone due to rapid resistance
* Beware drug interactions
* Near use in liver? Failure