Rickettsia prowazekii - Revision history

Aidan at 13:49, 5 August 2020

2020-08-05T13:49:17Z

← Older revision		Revision as of 13:49, 5 August 2020
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		⚫	==Background==

	* Cause of '''epidemic typhus'''		* Cause of '''epidemic typhus'''

⚫	==Background==
	===Microbiology===		===Microbiology===

	* One of the [[Rickettsiae]]		*One of the [[Rickettsiae]]

	===Life Cycle===		===Life Cycle===

	* Adult louse becomes infected when feeding on a rickettsemic patient		*Adult louse becomes infected when feeding on a rickettsemic patient
	* The louse poops on another person		*The louse poops on another person
	* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces		*The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces

	===Epidemiology===		===Epidemiology===

	* Carried by the human body louse, ''Pediculus humanus corporis''		*Carried by the human body louse, ''Pediculus humanus corporis''
	* Outbreaks are associated with poverty, refugee camps, jails, and cold climate		*Outbreaks are associated with poverty, refugee camps, jails, and cold climate
	* The only non-human reservoir is the flying squirrel (''Glaucomys volans'') in the US		*The only non-human reservoir is the flying squirrel (''Glaucomys volans'') in the US
	* Previously-infected patients may still have latent infection		*Previously-infected patients may still have latent infection

	==Clinical Manifestations==		==Clinical Manifestations==

	* Incubation period [[Usual incubation period::1 to 2 weeks]]		*Incubation period [[Usual incubation period::1 to 2 weeks]]
	* High fever, severe headache, myalgia, non-producive cough, delirium		*High fever, severe headache, myalgia, non-producive cough, delirium
	* Dull, red rash starting on the trunk and spreading peripherally		*Dull, red rash starting on the trunk and spreading peripherally
	** Spares palms and soles		**Spares palms and soles
	** Rash not always present		**Rash not always present
	* Delirium, hemorrhagic rash		*Delirium, hemorrhagic rash
	* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death		*In its severe form, can progress to pulmonary edema, encephalitis, shock, and death

	===Brill-Zinsser disease (BZD)===		===Brill-Zinsser disease (BZD)===

	* Reactivation or recrudescence of dormant typhus years after the initial infection		*Reactivation or recrudescence of dormant typhus years after the initial infection
	* Often in the context of malnutrition, chronic illness, and poor hygeine		*Often in the context of malnutrition, chronic illness, and poor hygeine
	* Rash may be evanescent or absent, and resolves faster		*Rash may be evanescent or absent, and resolves faster

	==Diagnosis==		==Diagnosis==

	* Four-fold rise in indirect immunofluorescence assay for IgG		*Four-fold rise in indirect immunofluorescence assay for IgG
	* PCR may be useful during acute illness		*PCR may be useful during acute illness

	==Management==		==Management==

	* Need to treat even without confirmed diagnosis		*Need to treat even without confirmed diagnosis
	* Doxycycline 100 mg po bid for 7 to 10 days, until afebrile for 24 to 48 hours		*[[Is treated by::Doxycycline]] 100 mg po bid for 7 to 10 days, until afebrile for 24 to 48 hours
	* Chloramphenicol is the alternative		*[[Is treated by::Chloramphenicol]] is the alternative
	* Wash clothing to prevent outbreaks		*Wash clothing to prevent outbreaks

	{{DISPLAYTITLE:''Rickettsia prowazekii''}}		{{DISPLAYTITLE:''Rickettsia prowazekii''}}

Aidan: /* Clinical Manifestations */

2020-08-05T13:48:32Z

Clinical Manifestations

← Older revision		Revision as of 13:48, 5 August 2020
Line 18:		Line 18:

	==Clinical Manifestations==		==Clinical Manifestations==
	* Incubation 1 to 2 weeks		* Incubation period [[Usual incubation period::1 to 2 weeks]]
	* High fever, severe headache, myalgia, non-producive cough, delirium		* High fever, severe headache, myalgia, non-producive cough, delirium
	* Dull, red rash starting on the trunk and spreading peripherally		* Dull, red rash starting on the trunk and spreading peripherally

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-14T16:32:51Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 16:32, 14 July 2020
Line 17:		Line 17:
	* Previously-infected patients may still have latent infection		* Previously-infected patients may still have latent infection

	==Clinical ~~Presentation~~==		==Clinical Manifestations==
	* Incubation 1 to 2 weeks		* Incubation 1 to 2 weeks
	* High fever, severe headache, myalgia, non-producive cough, delirium		* High fever, severe headache, myalgia, non-producive cough, delirium

Aidan: /* Background */

2020-06-30T18:35:31Z

Background

← Older revision		Revision as of 18:35, 30 June 2020
Line 2:		Line 2:

	==Background==		==Background==
			===Microbiology===
			* One of the [[Rickettsiae]]

	===Life Cycle===		===Life Cycle===
	* Adult louse becomes infected when feeding on a rickettsemic patient		* Adult louse becomes infected when feeding on a rickettsemic patient

Aidan at 18:34, 30 June 2020

2020-06-30T18:34:12Z

← Older revision		Revision as of 18:34, 30 June 2020
Line 1:		Line 1:
	* Cause of '''epidemic typhus'''		* Cause of '''epidemic typhus'''

	== ~~Life Cycle~~ ==		==Background==
			===Life Cycle===

	* Adult louse becomes infected when feeding on a rickettsemic patient		* Adult louse becomes infected when feeding on a rickettsemic patient
	* The louse poops on another person		* The louse poops on another person
	* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces		* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces

	== Epidemiology ==		===Epidemiology===

	* Carried by the human body louse, ''Pediculus humanus corporis''		* Carried by the human body louse, ''Pediculus humanus corporis''
Line 14:		Line 14:
	* Previously-infected patients may still have latent infection		* Previously-infected patients may still have latent infection

	== Clinical Presentation ==		==Clinical Presentation==

	* Incubation 1 to 2 weeks		* Incubation 1 to 2 weeks
	* High fever, severe headache, myalgia, non-producive cough, delirium		* High fever, severe headache, myalgia, non-producive cough, delirium
Line 24:		Line 23:
	* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death		* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death

	=== Brill-Zinsser disease (BZD) ===		===Brill-Zinsser disease (BZD)===

	* Reactivation or recrudescence of dormant typhus years after the initial infection		* Reactivation or recrudescence of dormant typhus years after the initial infection
	* Often in the context of malnutrition, chronic illness, and poor hygeine		* Often in the context of malnutrition, chronic illness, and poor hygeine
	* Rash may be evanescent or absent, and resolves faster		* Rash may be evanescent or absent, and resolves faster

	== Diagnosis ==		==Diagnosis==

	* Four-fold rise in indirect immunofluorescence assay for IgG		* Four-fold rise in indirect immunofluorescence assay for IgG
	* PCR may be useful during acute illness		* PCR may be useful during acute illness

	== Management ==		==Management==

	* Need to treat even without confirmed diagnosis		* Need to treat even without confirmed diagnosis
	* Doxycycline 100 mg po bid for 7 to 10 days, until afebrile for 24 to 48 hours		* Doxycycline 100 mg po bid for 7 to 10 days, until afebrile for 24 to 48 hours

Aidan at 20:13, 15 August 2019

2019-08-15T20:13:56Z

← Older revision		Revision as of 20:13, 15 August 2019
Line 1:		Line 1:
	* Cause of '''epidemic typhus'''		* Cause of '''epidemic typhus'''

	= Life Cycle =		== Life Cycle ==

	* Adult louse becomes infected when feeding on a rickettsemic patient		* Adult louse becomes infected when feeding on a rickettsemic patient
Line 7:		Line 7:
	* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces		* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces

	= Epidemiology =		== Epidemiology ==

	* Carried by the human body louse, ''Pediculus humanus corporis''		* Carried by the human body louse, ''Pediculus humanus corporis''
Line 14:		Line 14:
	* Previously-infected patients may still have latent infection		* Previously-infected patients may still have latent infection

	= Clinical Presentation =		== Clinical Presentation ==

	* Incubation 1 to 2 weeks		* Incubation 1 to 2 weeks
Line 24:		Line 24:
	* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death		* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death

	== Brill-Zinsser disease (BZD) ==		=== Brill-Zinsser disease (BZD) ===

	* Reactivation or recrudescence of dormant typhus years after the initial infection		* Reactivation or recrudescence of dormant typhus years after the initial infection
Line 30:		Line 30:
	* Rash may be evanescent or absent, and resolves faster		* Rash may be evanescent or absent, and resolves faster

	= Diagnosis =		== Diagnosis ==

	* Four-fold rise in indirect immunofluorescence assay for IgG		* Four-fold rise in indirect immunofluorescence assay for IgG
	* PCR may be useful during acute illness		* PCR may be useful during acute illness

	= Management =		== Management ==

	* Need to treat even without confirmed diagnosis		* Need to treat even without confirmed diagnosis

Aidan at 00:31, 15 August 2019

2019-08-15T00:31:18Z

← Older revision		Revision as of 00:31, 15 August 2019
Line 1:		Line 1:
			* Cause of '''epidemic typhus'''
	= Epidemic typhus (''R. prowazekii'') =

	== Life Cycle ==		= Life Cycle =

	* Adult louse becomes infected when feeding on a rickettsemic patient		* Adult louse becomes infected when feeding on a rickettsemic patient
Line 7:		Line 7:
	* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces		* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces

	== Epidemiology ==		= Epidemiology =

	* Carried by the human body louse, ''Pediculus humanus corporis''		* Carried by the human body louse, ''Pediculus humanus corporis''
Line 14:		Line 14:
	* Previously-infected patients may still have latent infection		* Previously-infected patients may still have latent infection

	== Clinical Presentation ==		= Clinical Presentation =

	* Incubation 1 to 2 weeks		* Incubation 1 to 2 weeks
Line 24:		Line 24:
	* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death		* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death

	=== Brill-Zinsser disease (BZD) ===		== Brill-Zinsser disease (BZD) ==

	* Reactivation or recrudescence of dormant typhus years after the initial infection		* Reactivation or recrudescence of dormant typhus years after the initial infection
Line 30:		Line 30:
	* Rash may be evanescent or absent, and resolves faster		* Rash may be evanescent or absent, and resolves faster

	== Diagnosis ==		= Diagnosis =

	* Four-fold rise in indirect immunofluorescence assay for IgG		* Four-fold rise in indirect immunofluorescence assay for IgG
	* PCR may be useful during acute illness		* PCR may be useful during acute illness

	== Management ==		= Management =

	* Need to treat even without confirmed diagnosis		* Need to treat even without confirmed diagnosis
Line 41:		Line 41:
	* Chloramphenicol is the alternative		* Chloramphenicol is the alternative
	* Wash clothing to prevent outbreaks		* Wash clothing to prevent outbreaks

			{{DISPLAYTITLE:''Rickettsia prowazekii''}}
			[[Category:Rickettsioses]]

Aidan: Aidan moved page Epidemic typhus to Rickettsia prowazekii

2019-08-15T00:30:33Z

Aidan moved page Epidemic typhus to Rickettsia prowazekii

← Older revision		Revision as of 00:30, 15 August 2019
(No difference)

Aidan: Aidan moved page Epidemic typhus (R. prowazekii) to Epidemic typhus without leaving a redirect

2019-08-15T00:30:20Z

Aidan moved page Epidemic typhus (R. prowazekii) to Epidemic typhus without leaving a redirect

← Older revision	Revision as of 00:30, 15 August 2019
(No difference)

Maintenance script: Imported from text file

2019-08-11T18:05:52Z

Imported from text file

New page

= Epidemic typhus (''R. prowazekii'') =

== Life Cycle ==

* Adult louse becomes infected when feeding on a rickettsemic patient
* The louse poops on another person
* The person scratches their skin or touches their mucous membrane, innoculating themselves with louse feces

== Epidemiology ==

* Carried by the human body louse, ''Pediculus humanus corporis''
* Outbreaks are associated with poverty, refugee camps, jails, and cold climate
* The only non-human reservoir is the flying squirrel (''Glaucomys volans'') in the US
* Previously-infected patients may still have latent infection

== Clinical Presentation ==

* Incubation 1 to 2 weeks
* High fever, severe headache, myalgia, non-producive cough, delirium
* Dull, red rash starting on the trunk and spreading peripherally
** Spares palms and soles
** Rash not always present
* Delirium, hemorrhagic rash
* In its severe form, can progress to pulmonary edema, encephalitis, shock, and death

=== Brill-Zinsser disease (BZD) ===

* Reactivation or recrudescence of dormant typhus years after the initial infection
* Often in the context of malnutrition, chronic illness, and poor hygeine
* Rash may be evanescent or absent, and resolves faster

== Diagnosis ==

* Four-fold rise in indirect immunofluorescence assay for IgG
* PCR may be useful during acute illness

== Management ==

* Need to treat even without confirmed diagnosis
* Doxycycline 100 mg po bid for 7 to 10 days, until afebrile for 24 to 48 hours
* Chloramphenicol is the alternative
* Wash clothing to prevent outbreaks