Aidan: Created page with "== Background == * Chronic disorder characterized by inflammation of the intra- and extra-hepatic bile ducts * Commonly comorbid with ulcerative colitis (about 70% of cases) * Possibly a hereditary component == Clinical Manifestations == * Often asymptomatic, with persistent ALP elevation * Fatigue, pruritus, jaundice * Increased risk of hepatocellular carcinoma == Investigations == * Anti-smooth muscle antibodies; may also have posi..."

2025-06-27T15:40:32Z

Created page with "== Background == * Chronic disorder characterized by inflammation of the intra- and extra-hepatic bile ducts * Commonly comorbid with ulcerative colitis (about 70% of cases) * Possibly a hereditary component == Clinical Manifestations == * Often asymptomatic, with persistent ALP elevation * Fatigue, pruritus, jaundice * Increased risk of hepatocellular carcinoma == Investigations == * Anti-smooth muscle antibodies; may also have posi..."

New page

== Background ==

* Chronic disorder characterized by inflammation of the intra- and extra-hepatic bile ducts
* Commonly comorbid with [[ulcerative colitis]] (about 70% of cases)
* Possibly a hereditary component

== Clinical Manifestations ==

* Often asymptomatic, with persistent [[Alkaline phosphatase|ALP]] elevation
* Fatigue, pruritus, jaundice
* Increased risk of [[hepatocellular carcinoma]]

== Investigations ==

* Anti-smooth muscle antibodies; may also have positive ANA, RF, and p-ANCA

[[Category:Hepatology]]

Primary sclerosing cholangitis - Revision history