Aidan: Created page with "==Clinical Manifestations== * Fatigue and pruritus * Jaundice * Hepatosplenomegaly ==Investigations== * ALP always elevated (often very high), ALT may be mildly elevated * Antimitochondrial antibodies are 95% sensitive * ANA elevated in about 70% ==Diagnosis== * No extrahepatic biliary obstruction, no comorbidities affecting the liver, and at least two of the following three criteria: ALP greater than 1.5 times the upper limit of normal Antimitochondrial antibody..."

2023-01-12T16:00:24Z

Created page with "==Clinical Manifestations== * Fatigue and pruritus * Jaundice * Hepatosplenomegaly ==Investigations== * ALP always elevated (often very high), ALT may be mildly elevated * Antimitochondrial antibodies are 95% sensitive * ANA elevated in about 70% ==Diagnosis== * No extrahepatic biliary obstruction, no comorbidities affecting the liver, and at least two of the following three criteria: ** ALP greater than 1.5 times the upper limit of normal ** Antimitochondrial antibody..."

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==Clinical Manifestations==
* Fatigue and pruritus
* Jaundice
* Hepatosplenomegaly

==Investigations==
* ALP always elevated (often very high), ALT may be mildly elevated
* Antimitochondrial antibodies are 95% sensitive
* ANA elevated in about 70%

==Diagnosis==
* No extrahepatic biliary obstruction, no comorbidities affecting the liver, and at least two of the following three criteria:
** ALP greater than 1.5 times the upper limit of normal
** Antimitochondrial antibody titre of at least 1:40
*** Or sp100 or gp210 antibodies, if AMA negative
** Histologic evidence of BC showing nonsuppurative destructive cholangitis and destruction of interlobular bile ducts

==Management==
* [[Ursodeoxycholic acid]]

[[Category:Hepatology]]

Primary biliary cholangitis - Revision history