Post-acute sequalae of COVID-19 - Revision history

Aidan at 17:17, 27 September 2024

2024-09-27T17:17:46Z

← Older revision		Revision as of 17:17, 27 September 2024
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	*Affects somewhere around 40% of patients, depending on the definition		*Affects somewhere around 40% of patients, depending on the definition
	*More common in patients with risk factors for severe COVID-19 disease		*More common in patients with risk factors for severe COVID-19 disease
			*Less common in patients who have been vaccinated[[CiteRef::azzolini2022as]]
	*Less common in patients who have been vaccinated<ref>Azzolini E, Levi R, Sarti R, et al. Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers. ''JAMA.'' 2022;328(7):676–678. doi:[https://doi.org/10.1001/jama.2022.11691 10.1001/jama.2022.11691]</ref>

	=== Pathophysiology ===		=== Pathophysiology ===

Aidan at 12:36, 1 September 2022

2022-09-01T12:36:34Z

← Older revision		Revision as of 12:36, 1 September 2022
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	* Symptoms may be new, following initial recovery, or persistent from initial illness		* Symptoms may be new, following initial recovery, or persistent from initial illness
	* Symptoms may fluctuate		* Symptoms may fluctuate

			== Investigations ==

			* Consider CBC/liver/renal, TSH, CRP, ferritin, ±BNP, ±cortisol
			* Consider exercise tolerance tests
			* If ongoing respiratory symptoms, consider CXR at 12 weeks
			* If postural symptoms, get orthostatic vitals

	[[Category:Coronaviridae]]		[[Category:Coronaviridae]]

Aidan at 12:16, 1 September 2022

2022-09-01T12:16:18Z

← Older revision		Revision as of 12:16, 1 September 2022
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	==Background==		==Background==

			* Also called post-acute sequalae of COVID-19 (PASC), post-acute COVID-19 syndrome (PACS), long, long-haul, or chronic COVID

	===Epidemiology===		===Epidemiology===

			*Unfortunately, studies use a variety of definitions
			*Affects somewhere around 40% of patients, depending on the definition
	*More common in patients with risk factors for severe COVID-19 disease		*More common in patients with risk factors for severe COVID-19 disease
			*Less common in patients who have been vaccinated<ref>Azzolini E, Levi R, Sarti R, et al. Association Between BNT162b2 Vaccination and Long COVID After Infections Not Requiring Hospitalization in Health Care Workers. ''JAMA.'' 2022;328(7):676–678. doi:[https://doi.org/10.1001/jama.2022.11691 10.1001/jama.2022.11691]</ref>

			=== Pathophysiology ===

			* Unclear
			* Hypothesized to involve some combination of delayed resolution of inflammation, triggered autoimmunity, and persistent viral reservoir

	==Clinical Manifestations==		==Clinical Manifestations==
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	*More common after severe disease		*More common after severe disease
	*At 2 months, about 2/3 had symptoms, with 33 to 37% having cough or dyspnea and 13 to 23% has dysgeusia or anosmia[[CiteRef::chopra2020si]][[CiteRef::10.1016/j.cmi.2020.09.052]]		*At 2 months, about 2/3 had symptoms, with 33 to 37% having cough or dyspnea and 13 to 23% has dysgeusia or anosmia[[CiteRef::chopra2020si]][[CiteRef::10.1016/j.cmi.2020.09.052]]
	**Those with persistent symptoms were more likely to be aged 40 to 60 years and hospitalized		**Those with persistent symptoms were more likely to be aged 40 to 60 years and have been hospitalized
	*At 6 months, 75% had at least one symptom[[CiteRef::huang20216-]]		*At 6 months, 75% had at least one symptom[[CiteRef::huang20216-]]
	**Fatigue or weakness (63%)		**Fatigue or weakness (63%)
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	*A minority have changes to [[pulmonary function tests]] (8%) or chest x-ray (18%)[[CiteRef::moreno-pérez2021po]]		*A minority have changes to [[pulmonary function tests]] (8%) or chest x-ray (18%)[[CiteRef::moreno-pérez2021po]]
	*May have persistent [[lymphopenia]], elevated [[ferritin]], or elevated [[D-dimer]][[CiteRef::moreno-pérez2021po]]		*May have persistent [[lymphopenia]], elevated [[ferritin]], or elevated [[D-dimer]][[CiteRef::moreno-pérez2021po]]

	*
			== Diagnosis ==

			* Definitions vary widely

			=== WHO Clinical Case Definition ===

			* History of probable or confirmed SARS-CoV-2 infection
			* Onset usually within 3 months of infection
			* Symptoms last for at least 2 months, without another explanation
			* Fatigue, dyspnea, cognitive dysfunction, or others
			* Symptoms may be new, following initial recovery, or persistent from initial illness
			* Symptoms may fluctuate

	[[Category:Coronaviridae]]		[[Category:Coronaviridae]]

Aidan: /* Clinical Manifestations */

2021-03-06T15:50:15Z

Clinical Manifestations

← Older revision		Revision as of 15:50, 6 March 2021
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	**Dysgeusia or anosmia (10%)		**Dysgeusia or anosmia (10%)
	*A minority have changes to [[pulmonary function tests]] (8%) or chest x-ray (18%)[[CiteRef::moreno-pérez2021po]]		*A minority have changes to [[pulmonary function tests]] (8%) or chest x-ray (18%)[[CiteRef::moreno-pérez2021po]]
	*May have persistent [[lymphopenia]], elevated [[ferritin]], or elevated [[D-dimer]]		*May have persistent [[lymphopenia]], elevated [[ferritin]], or elevated [[D-dimer]][[CiteRef::moreno-pérez2021po]]
	*		*

Aidan: /* Clinical Manifestations */

2021-03-06T15:49:54Z

Clinical Manifestations

← Older revision		Revision as of 15:49, 6 March 2021
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	**Hair loss (22%)		**Hair loss (22%)
	**Dysgeusia or anosmia (10%)		**Dysgeusia or anosmia (10%)
			*A minority have changes to [[pulmonary function tests]] (8%) or chest x-ray (18%)[[CiteRef::moreno-pérez2021po]]
			*May have persistent [[lymphopenia]], elevated [[ferritin]], or elevated [[D-dimer]]
	*		*

Aidan at 15:39, 6 March 2021

2021-03-06T15:39:40Z

← Older revision		Revision as of 15:39, 6 March 2021
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	== Background ==		==Background==

	=== Epidemiology ===		===Epidemiology===

	* More common in patients with risk factors for severe COVID-19 disease		*More common in patients with risk factors for severe COVID-19 disease

	== Clinical Manifestations ==		==Clinical Manifestations==

	* Fatigue, dyspnea, chest pain, brain fog		*Fatigue, dyspnea, chest pain, brain fog
	* More common after severe disease		*More common after severe disease
			*At 2 months, about 2/3 had symptoms, with 33 to 37% having cough or dyspnea and 13 to 23% has dysgeusia or anosmia[[CiteRef::chopra2020si]][[CiteRef::10.1016/j.cmi.2020.09.052]]
			**Those with persistent symptoms were more likely to be aged 40 to 60 years and hospitalized
			*At 6 months, 75% had at least one symptom[[CiteRef::huang20216-]]
			**Fatigue or weakness (63%)
			**Difficulty sleeping (26%)
			**Hair loss (22%)
			**Dysgeusia or anosmia (10%)
			*

	[[Category:Coronaviridae]]		[[Category:Coronaviridae]]

Aidan: Aidan moved page Post-COVID syndrome to Post-acute sequalae of COVID-19

2021-03-06T15:30:54Z

Aidan moved page Post-COVID syndrome to Post-acute sequalae of COVID-19

← Older revision		Revision as of 15:30, 6 March 2021
(No difference)

Aidan: Created page with "== Background == === Epidemiology === * More common in patients with risk factors for severe COVID-19 disease == Clinical Manifestations == * Fatigue, dyspnea, chest pain,..."

2021-02-13T21:26:41Z

Created page with "== Background == === Epidemiology === * More common in patients with risk factors for severe COVID-19 disease == Clinical Manifestations == * Fatigue, dyspnea, chest pain,..."

New page

== Background ==

=== Epidemiology ===

* More common in patients with risk factors for severe COVID-19 disease

== Clinical Manifestations ==

* Fatigue, dyspnea, chest pain, brain fog
* More common after severe disease

[[Category:Coronaviridae]]