Penicillin - Revision history

Aidan: /* Hypersensitivity Reactions */ typos

2026-04-17T14:15:16Z

Hypersensitivity Reactions: typos

← Older revision		Revision as of 14:15, 17 April 2026
Line 184:		Line 184:
	* Type IV:		* Type IV:
	** Delayed maculopapular drug rash		** Delayed maculopapular drug rash
	*** Usually after 7 to 10 days of starting and up to 1 to 3 days after stopping)		*** Usually after 7 to 10 days of starting, and up to 1 to 3 days after stopping
	*** Progresses over days, with lesions that are relatively fixed		*** Progresses over days, with lesions that are relatively fixed
	*** Can worsen over a few days after stopping, then resolves over 1 to 2 weeks		*** Can worsen over a few days after stopping, then resolves over 1 to 2 weeks
	*** ~~Pruritis~~ is variable		*** Pruritus is variable
	*** Most commonly occur in the context of a viral infection		*** Most commonly occur in the context of a viral infection
	** [[Contact dermatitis]]		** [[Contact dermatitis]]

Aidan: /* Nomenclature */ typo

2026-04-17T14:14:16Z

Nomenclature: typo

← Older revision		Revision as of 14:14, 17 April 2026
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	\|procaine penicillin G		\|procaine penicillin G
	\|procaine benzylpenicillin		\|procaine benzylpenicillin
	procaine ~~penicilli~~		procaine penicillin
	\|less soluble, used for IM		\|less soluble, used for IM
	\|-		\|-

Aidan: added dosing

2022-08-30T18:44:27Z

added dosing

@@ Line 139: / Line 139: @@
+|
+|
 |}
 == Safety ==
-=== Adverse Events ===
+=== Adverse Reactions ===
 ==== Hypersensitivity Reactions ====

Aidan: Text replacement - " species]]" to "]]"

2022-01-26T19:51:26Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 19:51, 26 January 2022
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	===Spectrum of Activity===		===Spectrum of Activity===

	*Generally active against Gram-positive cocci, especially [[streptococci]] but some strains of [[Staphylococcus aureus]], most [[clostridia]], [[Neisseria ~~species~~]], and some [[Haemophilus influenzae]]		*Generally active against Gram-positive cocci, especially [[streptococci]] but some strains of [[Staphylococcus aureus]], most [[clostridia]], [[Neisseria]], and some [[Haemophilus influenzae]]
	*Not active against aerobic Gram-negative bacilli		*Not active against aerobic Gram-negative bacilli
	*Penicillin G is generally more active than penicillin V across all bacteria		*Penicillin G is generally more active than penicillin V across all bacteria
Line 60:		Line 60:
	\|		\|
	\|-		\|-
	\|[[Enterococcus ~~species~~]]		\|[[Enterococcus]]
	\|≤8		\|≤8
	\|		\|
Line 84:		Line 84:
	\|		\|
	\|-		\|-
	\|[[Staphylococcus ~~species~~]]		\|[[Staphylococcus]]
	\|≤0.12		\|≤0.12
	\|		\|
Line 124:		Line 124:
	\|		\|
	\|-		\|-
	\|[[Streptococcus ~~species~~]] (β-hemolytic)		\|[[Streptococcus]] (β-hemolytic)
	\|≤0.12		\|≤0.12
	\|		\|
Line 132:		Line 132:
	\|		\|
	\|-		\|-
	\|[[Streptococcus ~~species~~]] (viridans group)		\|[[Streptococcus]] (viridans group)
	\|≤0.12		\|≤0.12
	\|0.25-2		\|0.25-2

Aidan at 19:11, 22 May 2021

2021-05-22T19:11:21Z

← Older revision		Revision as of 19:11, 22 May 2021
Line 159:		Line 159:
	*** Most commonly occur in the context of a viral infection		*** Most commonly occur in the context of a viral infection
	** [[Contact dermatitis]]		** [[Contact dermatitis]]
		⚫	[[Category:Β-lactams]]

⚫	[[Category:~~Beta~~-lactams]]

Aidan at 18:21, 25 February 2021

2021-02-25T18:21:10Z

← Older revision		Revision as of 18:21, 25 February 2021
Line 1:		Line 1:
	==Background==		==Background==

	=== Nomenclature ===		===Nomenclature===

	* Broadly speaking, formulations of penicillin G are soluble and used for IV or IM administration, and penicillin V is used for oral administration but does not achieve high levels in the serum		*Broadly speaking, formulations of penicillin G are soluble and used for IV or IM administration, and penicillin V is used for oral administration but does not achieve high levels in the serum

	{\| class="wikitable"		{\| class="wikitable"
Line 33:		Line 33:
	*Directly inhibits [[Penicillin-binding protein\|penicillin-binding proteins]]		*Directly inhibits [[Penicillin-binding protein\|penicillin-binding proteins]]

	=== Spectrum of Activity ===		===Spectrum of Activity===

	* Generally active against Gram-positive cocci, especially [[streptococci]] but some strains of [[Staphylococcus aureus]], most [[clostridia]], [[Neisseria species]], and some [[Haemophilus influenzae]]		*Generally active against Gram-positive cocci, especially [[streptococci]] but some strains of [[Staphylococcus aureus]], most [[clostridia]], [[Neisseria species]], and some [[Haemophilus influenzae]]
	* Not active against aerobic Gram-negative bacilli		*Not active against aerobic Gram-negative bacilli
	* Penicillin G is generally more active than penicillin V across all bacteria		*Penicillin G is generally more active than penicillin V across all bacteria

	=== Clinical Breakpoints ===		===Clinical Breakpoints===
	{\| class="wikitable"		{\| class="wikitable"
	! rowspan="2" \|Species		! rowspan="2" \|Species
Line 140:		Line 140:
	\|		\|
	\|}		\|}

			== Safety ==

			=== Adverse Events ===

			==== Hypersensitivity Reactions ====

			* Can cause any type of [[hypersensitivity reaction]] (I to IV)
			* Type I: [[anaphylaxis]] and [[urticaria]]
			* Type II: [[autoimmune hemolytic anemia]]
			* Type III: [[serum sickness-like reaction]]
			* Type IV:
			** Delayed maculopapular drug rash
			*** Usually after 7 to 10 days of starting and up to 1 to 3 days after stopping)
			*** Progresses over days, with lesions that are relatively fixed
			*** Can worsen over a few days after stopping, then resolves over 1 to 2 weeks
			*** Pruritis is variable
			*** Most commonly occur in the context of a viral infection
			** [[Contact dermatitis]]

	[[Category:Beta-lactams]]		[[Category:Beta-lactams]]

Aidan at 15:19, 13 September 2020

2020-09-13T15:19:41Z

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Mechanism of action ===
+=== Nomenclature ===
 [[Category:Beta-lactams]]

Aidan at 14:09, 16 July 2020

2020-07-16T14:09:34Z

← Older revision		Revision as of 14:09, 16 July 2020
Line 1:		Line 1:
			== Background ==
	The best antibiotic

			=== Mechanism of action ===

			* Directly inhibits [[Penicillin-binding protein\|penicillin-binding proteins]]

	[[Category:Beta-lactams]]		[[Category:Beta-lactams]]

Aidan: Created page with "The best antibiotic Category:Beta-lactams"

2020-06-17T01:56:28Z

Created page with "The best antibiotic Category:Beta-lactams"

New page

The best antibiotic

[[Category:Beta-lactams]]