Oseltamivir - Revision history

Aidan: /* Dose */

2020-07-31T14:52:59Z

Dose

← Older revision		Revision as of 14:52, 31 July 2020
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	\|}		\|}

	=== ~~Pediatric~~ ===		==== Hepatic Dosing ====

			* No dose adjustment needed
⚫	* Influenza (treatment):

	** Infants ≤8 months: 3 mg/kg/dose PO bid
			===Pediatric===
	** Infants ≥9 months: 3.5 mg/kg/dose PO bid

⚫	** Children ≤15 kg: 30 mg PO bid
		⚫	*Influenza (treatment):
⚫	** Children >15 to 23 kg: 45 mg PO bid
	** ~~Children~~ ~~>23 to 40 kg~~: 60 mg PO bid		**Infants ≤8 months: 3 mg/kg/dose PO bid
	** ~~Children~~ ~~& adolescents >40 kg~~: 75 mg PO bid ~~(adult dose)~~		**Infants ≥9 months: 3.5 mg/kg/dose PO bid
		⚫	**Children ≤15 kg: 30 mg PO bid
⚫	** Duration 5 days, started within 48 hours of illness onset
		⚫	**Children >15 to 23 kg: 45 mg PO bid
⚫	* Influenza (prophylaxis):
	** ~~Same~~ ~~doses~~ as ~~above,~~ ~~used~~ ~~once~~ ~~daily instead of~~ bid		**Children >23 to 40 kg: 60 mg PO bid
			**Children & adolescents >40 kg: 75 mg PO bid (adult dose)
		⚫	**Duration 5 days, started within 48 hours of illness onset
		⚫	*Influenza (prophylaxis):
			**Same doses as above, used once daily instead of bid

	[[Category:Antivirals]]		[[Category:Antivirals]]

Aidan at 14:51, 31 July 2020

2020-07-31T14:51:53Z

← Older revision		Revision as of 14:51, 31 July 2020
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	===Mechanism of Action===		===Mechanism of Action===

	*Inhibits viral neuraminidase		*Inhibits viral neuraminidase, which is required for virion release after budding

	==Dose==		==Dose==
	===Adults===		===Adults===

	*Influenza (treatment): 75 mg PO bid		*Influenza (treatment): 75 mg PO bid for 5 days, started within 48 hours of illness onset
	*Influenza (prophylaxis): 75 mg PO daily		*Influenza (prophylaxis): 75 mg PO daily

Line 17:		Line 17:
	!CrCl >10 to 30 mL/min		!CrCl >10 to 30 mL/min
	!IHD		!IHD
			!CAPD
			!CRRT
	\|-		\|-
	\|Influenza (treatment)		\|Influenza (treatment)
Line 23:		Line 25:
	\|30 mg PO daily		\|30 mg PO daily
	\|30 (low-flux) to 75 (high-flux) mg PO after dialysis		\|30 (low-flux) to 75 (high-flux) mg PO after dialysis
			\|30 mg PO once
			\|30 mg once daily
	\|-		\|-
	\|Influenza (prophylaxis)		\|Influenza (prophylaxis)
Line 29:		Line 33:
	\|30 mg PO every other day		\|30 mg PO every other day
	\|30 mg PO after every other dialysis		\|30 mg PO after every other dialysis
			\|30 mg PO weekly
			\|Unclear
	\|}		\|}

			=== Pediatric ===

			* Influenza (treatment):
			** Infants ≤8 months: 3 mg/kg/dose PO bid
			** Infants ≥9 months: 3.5 mg/kg/dose PO bid
			** Children ≤15 kg: 30 mg PO bid
			** Children >15 to 23 kg: 45 mg PO bid
			** Children >23 to 40 kg: 60 mg PO bid
			** Children & adolescents >40 kg: 75 mg PO bid (adult dose)
			** Duration 5 days, started within 48 hours of illness onset
			* Influenza (prophylaxis):
			** Same doses as above, used once daily instead of bid

	[[Category:Antivirals]]		[[Category:Antivirals]]

Aidan: /* Renal Dosing */

2020-07-31T14:46:58Z

Renal Dosing

← Older revision		Revision as of 14:46, 31 July 2020
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	====Renal Dosing====		====Renal Dosing====
	{\| class~~="wikitable" style~~="wikitable"		{\| class="wikitable"
	!Indication		!Indication
	!CrCl >60		!CrCl >60

Aidan at 14:46, 31 July 2020

2020-07-31T14:46:49Z

← Older revision		Revision as of 14:46, 31 July 2020
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	== Background ==		==Background==
	=== Mechanism of Action ===		===Mechanism of Action===
⚫	* Inhibits viral neuraminidase

		⚫	*Inhibits viral neuraminidase
⚫	== Dose ==
⚫	=== Adults ===
⚫	* Influenza (treatment): 75 mg PO bid
⚫	* Influenza (prophylaxis): 75 mg PO daily

		⚫	==Dose==
⚫	==== Renal Dosing ====
		⚫	===Adults===
⚫	{\| style="wikitable"

⚫	! Indication
		⚫	*Influenza (treatment): 75 mg PO bid
⚫	! CrCl >60
		⚫	*Influenza (prophylaxis): 75 mg PO daily
⚫	! CrCl >30 to 60 mL/min

⚫	! CrCl >10 to 30 mL/min
		⚫	====Renal Dosing====
⚫	! IHD
		⚫	{\| class="wikitable" style="wikitable"
		⚫	!Indication
		⚫	!CrCl >60
		⚫	!CrCl >30 to 60 mL/min
		⚫	!CrCl >10 to 30 mL/min
		⚫	!IHD
	\|-		\|-
	\| Influenza (treatment)		\|Influenza (treatment)
	\| Usual dose		\|Usual dose
	\| 30 mg PO bid		\|30 mg PO bid
	\| 30 mg PO daily		\|30 mg PO daily
	\| 30 (low-flux) to 75 (high-flux) mg PO after dialysis		\|30 (low-flux) to 75 (high-flux) mg PO after dialysis
	\|-		\|-
	\| Influenza (prophylaxis)		\|Influenza (prophylaxis)
	\| Usual dose		\|Usual dose
	\| 30 mg PO daily		\|30 mg PO daily
	\| 30 mg PO every other day		\|30 mg PO every other day
	\| 30 mg PO after every other dialysis		\|30 mg PO after every other dialysis
	\|}		\|}

Aidan: Created page with "== Background == === Mechanism of Action === * Inhibits viral neuraminidase == Dose == === Adults === * Influenza (treatment): 75 mg PO bid * Influenza (prophylaxis): 75 mg P..."

2020-07-31T14:46:36Z

Created page with "== Background == === Mechanism of Action === * Inhibits viral neuraminidase == Dose == === Adults === * Influenza (treatment): 75 mg PO bid * Influenza (prophylaxis): 75 mg P..."

New page

== Background ==
=== Mechanism of Action ===
* Inhibits viral neuraminidase

== Dose ==
=== Adults ===
* Influenza (treatment): 75 mg PO bid
* Influenza (prophylaxis): 75 mg PO daily

==== Renal Dosing ====
{| style="wikitable"
! Indication
! CrCl >60
! CrCl >30 to 60 mL/min
! CrCl >10 to 30 mL/min
! IHD
|-
| Influenza (treatment)
| Usual dose
| 30 mg PO bid
| 30 mg PO daily
| 30 (low-flux) to 75 (high-flux) mg PO after dialysis
|-
| Influenza (prophylaxis)
| Usual dose
| 30 mg PO daily
| 30 mg PO every other day
| 30 mg PO after every other dialysis
|}

[[Category:Antivirals]]