Oropouche virus - Revision history

Aidan at 13:44, 13 March 2025

2025-03-13T13:44:40Z

← Older revision		Revision as of 13:44, 13 March 2025
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	=== Epidemiology ===		=== Epidemiology ===

	* Transmitted by mosquitoes and midges		* Transmitted by Transmitted by::Culex quinquefasciatus mosquitoes and [[Transmitted by::Culicoides paraensis]] midges
	* Causes periodic outbreaks in the Amazon Basin, but has since spread to other parts of South America and the Caribbean		* Causes periodic outbreaks in the Amazon Basin, but has since spread to other parts of South America and the Caribbean
	** Bolivia, Brazil, Colombia, Cuba, Guyana, Peru, Ecuador, and Panama		** Bolivia, Brazil, Colombia, Cuba, Guyana, Peru, Ecuador, and Panama
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	== Diagnosis ==		== Diagnosis ==

	* PCR ~~available~~ ~~for~~ serum, ~~CSF,~~ urine~~, tissue~~		* PCR done on serum and urine
			** Can also be done on CSF and tissue
	** Ideally collected as soon as possible, up to 10 days of symptom onset		** Ideally collected as soon as possible, up to 10 days of symptom onset
	* Serology also available but plaque reduction neutralization test (PRNT)		* Serology also available but plaque reduction neutralization test (PRNT)
	** Acute (collected within 7 days of symptoms) and convalescent (2 to 3 weeks after the first collection) are required		** Acute (collected within 7 days of symptoms) and convalescent (2 to 3 weeks after the first collection) are required

			== Treatment ==

			* Supportive care

Aidan at 13:42, 13 March 2025

2025-03-13T13:42:57Z

← Older revision		Revision as of 13:42, 13 March 2025
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	** May have maculopapular rash starting on trunk and spreading to extremities		** May have maculopapular rash starting on trunk and spreading to extremities
	* Occasionally can have conjunctival injection, diarrhea, severe abdominal pain, and hemorrhagic symptoms		* Occasionally can have conjunctival injection, diarrhea, severe abdominal pain, and hemorrhagic symptoms
⚫	* Lasts for up to a week, but can recur days or weeks later
	* Bloodwork may show lymphopenia, elevated CRP, and mildly elevated liver enzymes		* Bloodwork may show lymphopenia, elevated CRP, and mildly elevated liver enzymes
			* Overall usually mild and self-limited
		⚫	* Lasts for up to a week, but can recur days or weeks later

	=== Neuroinvasive Disease ===		=== Neuroinvasive Disease ===

Aidan: Created page with "== Background == === Microbiology === * Member of the family Family::Peribunyaviridae and genus Genus::Orthobunyavirus within the Simbu serogroup === Epidemiology === * Transmitted by mosquitoes and midges * Causes periodic outbreaks in the Amazon Basin, but has since spread to other parts of South America and the Caribbean Bolivia, Brazil, Colombia, Cuba, Guyana, Peru, Ecuador, and Panama But also Argentina, French Guiana, Haiti, and Trinidad and Tobag..."

2025-03-13T13:42:20Z

Created page with "== Background == === Microbiology === * Member of the family Family::Peribunyaviridae and genus Genus::Orthobunyavirus within the Simbu serogroup === Epidemiology === * Transmitted by mosquitoes and midges * Causes periodic outbreaks in the Amazon Basin, but has since spread to other parts of South America and the Caribbean ** Bolivia, Brazil, Colombia, Cuba, Guyana, Peru, Ecuador, and Panama ** But also Argentina, French Guiana, Haiti, and Trinidad and Tobag..."

New page

== Background ==

=== Microbiology ===

* Member of the family [[Family::Peribunyaviridae]] and genus [[Genus::Orthobunyavirus]] within the Simbu serogroup

=== Epidemiology ===

* Transmitted by mosquitoes and midges
* Causes periodic outbreaks in the Amazon Basin, but has since spread to other parts of South America and the Caribbean
** Bolivia, Brazil, Colombia, Cuba, Guyana, Peru, Ecuador, and Panama
** But also Argentina, French Guiana, Haiti, and Trinidad and Tobago
** Cases now appearing in Barbados and Cuba

=== History ===

* Originally detected in 1955 in a person from the Vega de Oropouche village in Trinidad and Tobago, along the Oropouche River

== Clinical Manifestations ==

* Incubation period [[Usual incubation period::3 to 10 days]]
* Starts with fever, headache (often severe), chills, myalgias, arthralgias
** May have photophobia, dizziness, retroorbital/eye pain, nausea/vomiting
** May have maculopapular rash starting on trunk and spreading to extremities
* Occasionally can have conjunctival injection, diarrhea, severe abdominal pain, and hemorrhagic symptoms
* Lasts for up to a week, but can recur days or weeks later
* Bloodwork may show lymphopenia, elevated CRP, and mildly elevated liver enzymes

=== Neuroinvasive Disease ===

* In up to 4% of patients affected, it can cause meningitis or encephalitis
* A few case reports of [[Guillain-Barré syndrome]] 10 to 11 days after onset of symptoms

== Diagnosis ==

* PCR available for serum, CSF, urine, tissue
** Ideally collected as soon as possible, up to 10 days of symptom onset
* Serology also available but plaque reduction neutralization test (PRNT)
** Acute (collected within 7 days of symptoms) and convalescent (2 to 3 weeks after the first collection) are required