Orientia tsutsugamushi - Revision history

Aidan at 17:13, 27 September 2024

2024-09-27T17:13:08Z

← Older revision		Revision as of 17:13, 27 September 2024
Line 27:		Line 27:
	* [[Doxycycline]] 100 mg po bid for 7 days		* [[Doxycycline]] 100 mg po bid for 7 days
	* Alternative: [[azithromycin]] 500 mg p.o. daily for 1-3 days		* Alternative: [[azithromycin]] 500 mg p.o. daily for 1-3 days
			* For severe disease, combination [[doxycycline]] and [[azithromycin]] for 7 days[[CiteRef::varghese2023in]]
	* For severe disease, combination [[doxycycline]] and [[azithromycin]] for 7 days<ref>Varghese GM, Dayanand D, Gunasekaran K, Kundu D, Wyawahare M, Sharma N, Chaudhry D, Mahajan SK, Saravu K, Aruldhas BW, Mathew BS, Nair RG, Newbigging N, Mathew A, Abhilash KPP, Biswal M, Prasad AH, Zachariah A, Iyadurai R, Hansdak SG, Sathyendra S, Sudarsanam TD, Prakash JAJ, Manesh A, Mohan A, Tarning J, Blacksell SD, Peerawaranun P, Waithira N, Mukaka M, Cheah PY, Peter JV, Abraham OC, Day NPJ; INTREST Trial Investigators. Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus. N Engl J Med. 2023 Mar 2;388(9):792-803. doi: 10.1056/NEJMoa2208449. PMID: 36856615.</ref>
	** Dosing may be unusual: doxycycline 200 mg bid x2 followed by 100 mg bid; azithromycin 500 mg bid x2 followed by 500 mg daily		** Dosing may be unusual: [[doxycycline]] 200 mg bid x2 followed by 100 mg bid; [[azithromycin]] 500 mg bid x2 followed by 500 mg daily

	{{DISPLAYTITLE:''Orientia tsutsugamushi''}}		{{DISPLAYTITLE:''Orientia tsutsugamushi''}}

Aidan at 15:15, 2 March 2023

2023-03-02T15:15:16Z

← Older revision		Revision as of 15:15, 2 March 2023
Line 26:		Line 26:
	== Management ==		== Management ==
	* [[Doxycycline]] 100 mg po bid for 7 days		* [[Doxycycline]] 100 mg po bid for 7 days
			* Alternative: [[azithromycin]] 500 mg p.o. daily for 1-3 days
			* For severe disease, combination [[doxycycline]] and [[azithromycin]] for 7 days<ref>Varghese GM, Dayanand D, Gunasekaran K, Kundu D, Wyawahare M, Sharma N, Chaudhry D, Mahajan SK, Saravu K, Aruldhas BW, Mathew BS, Nair RG, Newbigging N, Mathew A, Abhilash KPP, Biswal M, Prasad AH, Zachariah A, Iyadurai R, Hansdak SG, Sathyendra S, Sudarsanam TD, Prakash JAJ, Manesh A, Mohan A, Tarning J, Blacksell SD, Peerawaranun P, Waithira N, Mukaka M, Cheah PY, Peter JV, Abraham OC, Day NPJ; INTREST Trial Investigators. Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus. N Engl J Med. 2023 Mar 2;388(9):792-803. doi: 10.1056/NEJMoa2208449. PMID: 36856615.</ref>
			** Dosing may be unusual: doxycycline 200 mg bid x2 followed by 100 mg bid; azithromycin 500 mg bid x2 followed by 500 mg daily

	{{DISPLAYTITLE:''Orientia tsutsugamushi''}}		{{DISPLAYTITLE:''Orientia tsutsugamushi''}}

Aidan: Text replacement - " Stain::Gram" to " [[Stain::Gram"

2020-07-28T18:00:31Z

Text replacement - " Stain::Gram" to " [[Stain::Gram"

← Older revision		Revision as of 18:00, 28 July 2020
Line 1:		Line 1:
	* Chigger-borne [[Rickettsioses\|rickettsial infection]] caused by the intracellular Stain::Gram-negative]] bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''		* Chigger-borne [[Rickettsioses\|rickettsial infection]] caused by the intracellular [[Stain::Gram-negative]] bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''

	== Background ==		== Background ==

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-15T14:59:06Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 14:59, 15 July 2020
Line 9:		Line 9:
	* Most common in rural Asia and western Australia, as well as other parts of eastern Asia, including Russia and India		* Most common in rural Asia and western Australia, as well as other parts of eastern Asia, including Russia and India

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Fever, headache, myalgia, lymphadenopathy, and an eschar		* Fever, headache, myalgia, lymphadenopathy, and an eschar
	** Lymphadenopathy sometimes grouped near the eschar		** Lymphadenopathy sometimes grouped near the eschar

Aidan: Text replacement - "[[Has Gram stain::" to "Stain::"

2020-07-05T19:34:27Z

Text replacement - "[[Has Gram stain::" to "Stain::"

← Older revision		Revision as of 19:34, 5 July 2020
Line 1:		Line 1:
	* Chigger-borne [[Rickettsioses\|rickettsial infection]] caused by the intracellular ~~[[Has Gram stain~~::Gram-negative]] bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''		* Chigger-borne [[Rickettsioses\|rickettsial infection]] caused by the intracellular Stain::Gram-negative]] bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''

	== Background ==		== Background ==

Aidan: typo

2019-11-20T17:10:59Z

typo

← Older revision		Revision as of 17:10, 20 November 2019
Line 1:		Line 1:
	* Chigger-borne [[~~Ricketssioses~~\|rickettsial infection]] caused by the intracellular [[Has Gram stain::Gram-negative]] bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''		* Chigger-borne [[Rickettsioses\|rickettsial infection]] caused by the intracellular [[Has Gram stain::Gram-negative]] bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''

	== Background ==		== Background ==

Aidan: added to Life Cycle section

2019-11-20T17:10:43Z

added to Life Cycle section

← Older revision		Revision as of 17:10, 20 November 2019
Line 1:		Line 1:
	* Chigger-borne rickettsial infection caused by the intracellular Gram-negative bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''		* Chigger-borne [[Ricketssioses\|rickettsial infection]] caused by the intracellular [[Has Gram stain::Gram-negative]] bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''

	== ~~Life Cycle~~ ==		== Background ==
			=== Life Cycle ===

			* The entire life cycle is maintained within [[Is transmitted by::Leptotrombidium]] mites by vertical/transovarial transmission
	* Transmitted within mites (chiggers) transovarially
			* [[Leptotrombidium]] larvae (called '''chiggers''') normally feed on rodents, and occasionally humans, who are dead-end hosts

⚫	== Epidemiology ==

		⚫	=== Epidemiology ===
	* Most common in rural Asia and western Australia, as well as other parts of eastern Asia, including Russia and India		* Most common in rural Asia and western Australia, as well as other parts of eastern Asia, including Russia and India

	== Clinical Presentation ==		== Clinical Presentation ==

	* Fever, headache, myalgia, lymphadenopathy, and an eschar		* Fever, headache, myalgia, lymphadenopathy, and an eschar
	** Lymphadenopathy sometimes grouped near the eschar		** Lymphadenopathy sometimes grouped near the eschar
Line 22:		Line 21:

	== Diagnosis ==		== Diagnosis ==

	* Four-fold rise in immunofluorescence serology		* Four-fold rise in immunofluorescence serology
	* PCR on eschar, blood, or lymph node biopsy		* PCR on eschar, blood, or lymph node biopsy

	== Management ==		== Management ==

	* [[Doxycycline]] 100 mg po bid for 7 days		* [[Doxycycline]] 100 mg po bid for 7 days

Aidan at 20:15, 15 August 2019

2019-08-15T20:15:06Z

← Older revision		Revision as of 20:15, 15 August 2019
Line 1:		Line 1:
	* Chigger-borne rickettsial infection caused by the intracellular Gram-negative bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''		* Chigger-borne rickettsial infection caused by the intracellular Gram-negative bacterium ''Orientia tsutsugamushi'' that causes '''scrub typhus'''

	= Life Cycle =		== Life Cycle ==

	* Transmitted within mites (chiggers) transovarially		* Transmitted within mites (chiggers) transovarially

	= Epidemiology =		== Epidemiology ==

	* Most common in rural Asia and western Australia, as well as other parts of eastern Asia, including Russia and India		* Most common in rural Asia and western Australia, as well as other parts of eastern Asia, including Russia and India

	= Clinical Presentation =		== Clinical Presentation ==

	* Fever, headache, myalgia, lymphadenopathy, and an eschar		* Fever, headache, myalgia, lymphadenopathy, and an eschar
Line 21:		Line 21:
	* Infection also decreases HIV viral load and can lead to immune reconstitution		* Infection also decreases HIV viral load and can lead to immune reconstitution

	= Diagnosis =		== Diagnosis ==

	* Four-fold rise in immunofluorescence serology		* Four-fold rise in immunofluorescence serology
	* PCR on eschar, blood, or lymph node biopsy		* PCR on eschar, blood, or lymph node biopsy

	= Management =		== Management ==

	* [[Doxycycline]] 100 mg po bid for 7 days		* [[Doxycycline]] 100 mg po bid for 7 days

Aidan: /* Management */

2019-08-15T04:01:01Z

Management

← Older revision		Revision as of 04:01, 15 August 2019
Line 28:		Line 28:
	= Management =		= Management =

	* Doxycycline 100 mg po bid for 7 days		* [[Doxycycline]] 100 mg po bid for 7 days

	{{DISPLAYTITLE:''Orientia tsutsugamushi''}}		{{DISPLAYTITLE:''Orientia tsutsugamushi''}}

Aidan: /* Management */

2019-08-15T04:00:47Z

Management

← Older revision		Revision as of 04:00, 15 August 2019
Line 30:		Line 30:
	* Doxycycline 100 mg po bid for 7 days		* Doxycycline 100 mg po bid for 7 days

	{{DISPLAYTITLE:''Orientia tsutsugamushi'']]		{{DISPLAYTITLE:''Orientia tsutsugamushi''}}
	[[Category:Rickettsioses]]		[[Category:Rickettsioses]]