https://idwiki.org/index.php?action=history&feed=atom&title=Obesity_hypoventilation_syndrome 2026-05-15T16:59:18Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Obesity_hypoventilation_syndrome&diff=7848&oldid=prev 2021-05-15T01:08:39Z

<p>Created page with &quot;== Background == === Pathophysiology === * Caused by a combination of lectin deficiency causing muscle weakness, increased extrathoracic pressure from soft tissue, and incre...&quot;</p> <p><b>New page</b></p><div>== Background ==<br /> <br /> === Pathophysiology ===<br /> <br /> * Caused by a combination of lectin deficiency causing muscle weakness, increased extrathoracic pressure from soft tissue, and increased airway resistance<br /> <br /> == Clinical Manifestations ==<br /> <br /> * Almost all (90%) have concurrent [[obstructive sleep apnea]], and 70% have severe OSA<br /> <br /> == Investigations ==<br /> <br /> * Serum bicarbonate &lt;27 has a 97% negative predictive value<br /> * Polysomnography is used for diagnosis<br /> <br /> == Diagnosis ==<br /> <br /> * Obesity (BMI ≥30 kg·m−2)<br /> * Daytime hypercapnia with PaCO&lt;sub&gt;2&lt;/sub&gt; ≥45 mmHg<br /> * Sleep disordered breathing<br /> ** [[Obstructive sleep apnea]] (90%), or<br /> ** Non-obstructive sleep hypoventilation (10%), defined as either<br /> *** PaCO&lt;sub&gt;2&lt;/sub&gt; (or surrogate such as ETCO&lt;sub&gt;2&lt;/sub&gt; or transcutaneous CO&lt;sub&gt;2&lt;/sub&gt;) &gt;55 mmHg for &gt;10 min, or<br /> *** An increase in PaCO&lt;sub&gt;2&lt;/sub&gt; (or surrogate) &gt;10 mmHg compared to an awake supine value to a value &gt;50 mmHg for &gt;10 min<br /> * Exclusion of other causes of hypoventilation<br /> <br /> == Management ==<br /> <br /> * Treated with CPAP<br /> <br /> == Further Reading ==<br /> <br /> * Obesity hypoventilation syndrome. &#039;&#039;European Respir Rev&#039;&#039;. 2019;28:180097. doi: [https://doi.org/10.1183/16000617.0097-2018 10.1183/16000617.0097-2018]<br /> <br /> [[Category:Respirology]]<br /> [[Category:Bariatric medicine]]</div>

Aidan