https://idwiki.org/index.php?action=history&feed=atom&title=Nivolumab 2026-05-13T00:07:19Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Nivolumab&diff=11580&oldid=prev 2026-02-27T16:23:18Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:23, 27 February 2026</td> </tr><tr> <td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Background ==</div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* Immune checkpoint inhibitor targeting PD-1</div></td> <td colspan="2" class="diff-empty diff-side-added"></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* IgG4 human monoclonal antibody that binds PD-1 receptor on T cells, thus blocking it from interacting with PD-L1 and PD-L2</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Indicated for [[melanoma]], [[NSCLC]], [[SCLC]], [[RCC]], [[Hodgkin lymphoma]], head and neck squamous cell carcinoma, urothelial carcinoma, [[colorectal cancer]], [[hepatocellular carcinoma]], and esophageal squamous cell carcinoma</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Indicated for [[melanoma]], [[NSCLC]], [[SCLC]], [[RCC]], [[Hodgkin lymphoma]], head and neck squamous cell carcinoma, urothelial carcinoma, [[colorectal cancer]], [[hepatocellular carcinoma]], and esophageal squamous cell carcinoma</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* Not particularly immunosuppressive</div></td> <td colspan="2" class="diff-empty diff-side-added"></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>=== Pharmacokinetics ===</div></td> </tr> <tr> <td class="diff-marker"><a class="mw-diff-movedpara-left" title="Paragraph was moved. Click to jump to new location." href="#movedpara_8_4_rhs">&#x26AB;</a></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><a name="movedpara_7_0_lhs"></a>* <del style="font-weight: bold; text-decoration: none;">May</del> increase risk of routine bacterial infections (including <del style="font-weight: bold; text-decoration: none;">C.</del> difficile), fungal infections (aspergillosis, <del style="font-weight: bold; text-decoration: none;">pneumocystis</del>, candidemia), viral infections (VZV, CMV, EBV)</div></td> <td colspan="2" class="diff-empty diff-side-added"></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Half-life 27 days</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Safety ==</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker"><a class="mw-diff-movedpara-right" title="Paragraph was moved. Click to jump to old location." href="#movedpara_7_0_lhs">&#x26AB;</a></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><a name="movedpara_8_4_rhs"></a>* <ins style="font-weight: bold; text-decoration: none;">Not particularly immunosuppressive; may</ins> increase risk of routine bacterial infections (including <ins style="font-weight: bold; text-decoration: none;">[[Clostridioides</ins> difficile<ins style="font-weight: bold; text-decoration: none;">]]</ins>), fungal infections (<ins style="font-weight: bold; text-decoration: none;">[[</ins>aspergillosis<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[Pneumocystis]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>candidemia<ins style="font-weight: bold; text-decoration: none;">]]</ins>), viral infections (<ins style="font-weight: bold; text-decoration: none;">[[</ins>VZV<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>CMV<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>EBV<ins style="font-weight: bold; text-decoration: none;">]]</ins>)<ins style="font-weight: bold; text-decoration: none;">; case reports of [[CMV]] colitis</ins></div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Rash is common, generally presenting early</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Diarrhea as well, can be severe, as well as nausea/vomiting</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Fatigue quite common, affecting about a half of patients</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Electrolyte abnormalities</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Immune-mediated endocrinopathies that can include hypothyroidism, hyperthyroidism, hypophysitis, adrenal insufficiency, diabetes mellitus</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Cases of pneumonitis and interstitial lung disease, median onset 15 weeks</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Further Reading ==</div></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td colspan="2" class="diff-empty diff-side-deleted"></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* https://www.cancercareontario.ca/en/drugformulary/drugs/monograph/44416</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immune checkpoint inhibitors]]</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immune checkpoint inhibitors]]</div></td> </tr> <!-- diff cache key site7_mediawiki:diff:1.41:old-10073:rev-11580:wikidiff2=table:1.13.0:bc2a06be --> </table>

Aidan https://idwiki.org/index.php?title=Nivolumab&diff=10073&oldid=prev 2023-07-17T14:13:33Z

<p>Created page with &quot;* Immune checkpoint inhibitor targeting PD-1 * Indicated for <a href="/index.php?title=Melanoma&amp;action=edit&amp;redlink=1" class="new" title="Melanoma (page does not exist)">melanoma</a>, <a href="/index.php?title=NSCLC&amp;action=edit&amp;redlink=1" class="new" title="NSCLC (page does not exist)">NSCLC</a>, <a href="/index.php?title=SCLC&amp;action=edit&amp;redlink=1" class="new" title="SCLC (page does not exist)">SCLC</a>, <a href="/RCC" class="mw-redirect" title="RCC">RCC</a>, <a href="/index.php?title=Hodgkin_lymphoma&amp;action=edit&amp;redlink=1" class="new" title="Hodgkin lymphoma (page does not exist)">Hodgkin lymphoma</a>, head and neck squamous cell carcinoma, urothelial carcinoma, <a href="/Colorectal_cancer" title="Colorectal cancer">colorectal cancer</a>, <a href="/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">hepatocellular carcinoma</a>, and esophageal squamous cell carcinoma * Not particularly immunosuppressive * May increase risk of routine bacterial infections (including C. difficile), fungal infections (aspergillosis, pneumocystis, candidemia), viral infections (V...&quot;</p> <p><b>New page</b></p><div>* Immune checkpoint inhibitor targeting PD-1<br /> * Indicated for [[melanoma]], [[NSCLC]], [[SCLC]], [[RCC]], [[Hodgkin lymphoma]], head and neck squamous cell carcinoma, urothelial carcinoma, [[colorectal cancer]], [[hepatocellular carcinoma]], and esophageal squamous cell carcinoma<br /> * Not particularly immunosuppressive<br /> * May increase risk of routine bacterial infections (including C. difficile), fungal infections (aspergillosis, pneumocystis, candidemia), viral infections (VZV, CMV, EBV)<br /> <br /> [[Category:Immune checkpoint inhibitors]]</div>

Aidan