Nirmatrelvir-ritonavir - Revision history

Aidan at 14:42, 6 May 2025

2025-05-06T14:42:30Z

← Older revision		Revision as of 14:42, 6 May 2025
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			== Background ==

			* Indicated for mild to moderate [[COVID-19]] infection
			* Combination medication includes: [[nirmatrelvir]], a protease inhibitor that interferes with viral replication, and [[ritonavir]], which boosts levels of [[nirmatrelvir]] by interfering with CYP3A-mediated drug metabolism

	== Dosing ==		== Dosing ==

	* COVID-19: ~~Nirmatrelvir~~/ritonavir 300 mg/100 mg p.o. bid for 5 days~~, started within 5 days of symptom onset~~		* Mild-to-moderate [[COVID-19]] (within 5 days of symptom onset): nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days

	=== Renal Dosing ===		=== Renal Dosing ===
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	* eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid		* eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid
	* eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days		* eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days
			* Dialysis:
	* ~~Dialysis~~: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more ~~days, given after dialysis on dialysis~~ days		** Weight ≥40 kg: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days
			** Weight <40 kg: 150 mg/100 mg every 48 hours for 3 doses
			** Give after dialysis on dialysis days

	=== Hepatic Dosing ===		=== Hepatic Dosing ===

	* [[Child-Pugh classification\|Child-Pugh]] class C: contraindicated		* [[Child-Pugh classification\|Child-Pugh]] class C: contraindicated

			== Safety ==

			=== Contraindications ===

			* Hypersensitivity reaction
			* Severe liver disease ([[Child-Pugh classification\|Child-Pugh]] Class C)
			* Drug-drug interactions (check [https://www.covid19-druginteractions.org/checker Liverpool site])

	[[Category:Medications]]		[[Category:Medications]]

Aidan at 14:36, 24 July 2022

2022-07-24T14:36:58Z

← Older revision		Revision as of 14:36, 24 July 2022
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	* eGFR ≥60 mL/min: no adjustment		* eGFR ≥60 mL/min: no adjustment
	* eGFR 30-59 mL/min: ~~nirmetrelvir/ritonavir~~ 150 mg/100 mg p.o. bid		* eGFR 30-59 mL/min: 150 mg/100 mg p.o. bid
	* eGFR <30 mL/min: ~~not~~ ~~recommended~~		* eGFR <30 mL/min: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days
			* Dialysis: 300 mg/100 mg load on day 1, followed by 150 mg/100 mg p.o daily for 4 more days, given after dialysis on dialysis days

	=== Hepatic Dosing ===		=== Hepatic Dosing ===

Aidan at 17:54, 9 March 2022

2022-03-09T17:54:34Z

← Older revision		Revision as of 17:54, 9 March 2022
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	* eGFR 30-59 mL/min: nirmetrelvir/ritonavir 150 mg/100 mg p.o. bid		* eGFR 30-59 mL/min: nirmetrelvir/ritonavir 150 mg/100 mg p.o. bid
	* eGFR <30 mL/min: not recommended		* eGFR <30 mL/min: not recommended

			=== Hepatic Dosing ===

			* [[Child-Pugh classification\|Child-Pugh]] class C: contraindicated

	[[Category:Medications]]		[[Category:Medications]]

Aidan at 14:02, 18 January 2022

2022-01-18T14:02:12Z

← Older revision		Revision as of 14:02, 18 January 2022
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	* COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset		* COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset

			=== Renal Dosing ===

			* eGFR ≥60 mL/min: no adjustment
			* eGFR 30-59 mL/min: nirmetrelvir/ritonavir 150 mg/100 mg p.o. bid
			* eGFR <30 mL/min: not recommended

	[[Category:Medications]]		[[Category:Medications]]

Aidan: Created page with "== Dosing == * COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset Category:Medications"

2022-01-18T14:00:44Z

Created page with "== Dosing == * COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset Category:Medications"

New page

== Dosing ==

* COVID-19: Nirmatrelvir/ritonavir 300 mg/100 mg p.o. bid for 5 days, started within 5 days of symptom onset

[[Category:Medications]]