https://idwiki.org/index.php?action=history&feed=atom&title=Neuroleptic_malignant_syndrome 2026-05-13T01:05:01Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Neuroleptic_malignant_syndrome&diff=5122&oldid=prev 2020-07-21T01:47:35Z

<p>Text replacement - &quot;Clinical Presentation&quot; to &quot;Clinical Manifestations&quot;</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:47, 21 July 2020</td> </tr><tr> <td colspan="2" class="diff-lineno">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Adverse reaction to medication that blocks dopamine</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Adverse reaction to medication that blocks dopamine</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <del style="font-weight: bold; text-decoration: none;">Presentation</del> ==</div></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <ins style="font-weight: bold; text-decoration: none;">Manifestations</ins> ==</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Current antipsychotic use</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Current antipsychotic use</div></td> </tr> <!-- diff cache key site7_mediawiki:diff:1.41:old-4360:rev-5122:wikidiff2=table:1.13.0:bc2a06be --> </table>

Aidan https://idwiki.org/index.php?title=Neuroleptic_malignant_syndrome&diff=4360&oldid=prev 2020-07-04T01:17:47Z

<p>Imported from text file</p> <p><b>New page</b></p><div>== Definition ==<br /> <br /> * Adverse reaction to medication that blocks dopamine<br /> <br /> == Clinical Presentation ==<br /> <br /> * Current antipsychotic use<br /> ** Can occur at any time<br /> ** Especially common with first-generation antipsychotics like haloperidol<br /> * &#039;&#039;&#039;FARM&#039;&#039;&#039;: fever, autonomic dysfunction, rigidity, mental status changes<br /> * Hyperthermia<br /> * Autonomic dysfunction<br /> ** Hypertension<br /> ** Tachycardia<br /> ** Tachypnea<br /> ** Sweating<br /> * Rigidity<br /> * Mental status changes<br /> * Compared to [[serotonin syndrome]], NMS is more likely to have:<br /> ** More severe rigidity and hyperthermia<br /> ** Bradyreflexia<br /> ** Less acute onset<br /> ** Normal bowel sounds and pupils<br /> <br /> == Investigations ==<br /> <br /> * Labs<br /> ** CK will be elevated (rhabdomyolysis)<br /> <br /> == Management ==<br /> <br /> * Discontinue offending medication<br /> * Supportive therapy<br /> ** IV fluids<br /> ** Antipyretics<br /> ** Cooling blankets<br /> * Dantrolene, sometimes<br /> * D2 agonists like bromocriptine, maybe<br /> * If myoglobinuria: alkaline diuresis<br /> <br /> == Prognosis ==<br /> <br /> * Mortality is high at 10-20%<br /> <br /> [[Category:Neurology]]<br /> [[Category:Critical care]]</div>

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