Mycobacterium leprae - Revision history

Aidan at 20:01, 5 November 2021

2021-11-05T20:01:49Z

← Older revision		Revision as of 20:01, 5 November 2021
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	\|[[thalidomide]] 50 to 100 mg nightly		\|[[thalidomide]] 50 to 100 mg nightly
	\|}		\|}

			== Prevention ==

			* Unclear whether household contacts require prophylaxis[[CiteRef::boodman2021le]]
			** Some experts recommend prophylaxis, particularly for exposure to multibacillary patients
			** Regimen unclear; most Canadian experts use single-dose [[rifampin]], in accordance with WHO recommendations
			** May instead do annual screening by physical examination for between 2 and 10 years

2020-10-08T15:16:37Z

Text replacement - "[[Cellular shape::" to "[[Shape::"

← Older revision		Revision as of 15:16, 8 October 2020
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	===Microbiology===		===Microbiology===

	*Slow-growing [[Stain::Gram-positive]] and [[Stain::acid-fast]] [[~~Cellular shape~~::bacillus]]		*Slow-growing [[Stain::Gram-positive]] and [[Stain::acid-fast]] [[Shape::bacillus]]

	===Epidemiology===		===Epidemiology===

2020-09-17T17:57:39Z

2020-08-05T14:02:50Z

Clinical Manifestations

← Older revision		Revision as of 14:02, 5 August 2020
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	== Clinical Manifestations ==		== Clinical Manifestations ==
	* Following exposure, about 95% clear it spontaneously		* Following exposure, about 95% clear it spontaneously
	* For those who do not, there is an incubation period of 3-5 years (with wide range) that is usually followed by indeterminate leprosy		* For those who do not, there is an incubation period of [[Usual incubation period::3-5 years]] (with [[Incubation period range::wide range]]) that is usually followed by indeterminate leprosy
	** Single, ill-defined, hypopigmented skin lesion		** Single, ill-defined, hypopigmented skin lesion
	** About 75% spontaneously resolve, with the other 25% progressing		** About 75% spontaneously resolve, with the other 25% progressing

2020-08-05T14:02:31Z

Microbiology

← Older revision		Revision as of 14:02, 5 August 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Slow-growing [[Stain::Gram-positive]] and Stain::acid-fast]] [[Cellular shape::bacillus]]		* Slow-growing [[Stain::Gram-positive]] and [[Stain::acid-fast]] [[Cellular shape::bacillus]]

	=== Epidemiology ===		=== Epidemiology ===

2020-07-29T00:52:21Z

Text replacement - " Stain::Gram" to " [[Stain::Gram"

← Older revision		Revision as of 00:52, 29 July 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Slow-growing Stain::Gram-positive]] and Stain::acid-fast]] [[Cellular shape::bacillus]]		* Slow-growing [[Stain::Gram-positive]] and Stain::acid-fast]] [[Cellular shape::bacillus]]

	=== Epidemiology ===		=== Epidemiology ===

2020-07-16T13:55:40Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 13:55, 16 July 2020
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	* A Th2 CD4 response causes lepromatous leprosy, which is multibacillary and more progressive		* A Th2 CD4 response causes lepromatous leprosy, which is multibacillary and more progressive

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Following exposure, about 95% clear it spontaneously		* Following exposure, about 95% clear it spontaneously
	* For those who do not, there is an incubation period of 3-5 years (with wide range) that is usually followed by indeterminate leprosy		* For those who do not, there is an incubation period of 3-5 years (with wide range) that is usually followed by indeterminate leprosy

2020-07-05T20:43:00Z

Text replacement - "[[Has Gram stain::" to "Stain::"

← Older revision		Revision as of 20:43, 5 July 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Slow-growing ~~[[Has Gram stain~~::Gram-positive]] and ~~[[Has Gram stain~~::acid-fast]] [[Cellular shape::bacillus]]		* Slow-growing Stain::Gram-positive]] and Stain::acid-fast]] [[Cellular shape::bacillus]]

	=== Epidemiology ===		=== Epidemiology ===

2020-07-05T19:30:18Z

Text replacement - "[[Has shape::" to "[[Cellular shape::"

← Older revision		Revision as of 19:30, 5 July 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Slow-growing [[Has Gram stain::Gram-positive]] and [[Has Gram stain::acid-fast]] [[~~Has~~ shape::bacillus]]		* Slow-growing [[Has Gram stain::Gram-positive]] and [[Has Gram stain::acid-fast]] [[Cellular shape::bacillus]]

	=== Epidemiology ===		=== Epidemiology ===

2020-02-19T13:28:38Z

Clinical Presentation: added skin manifestations

← Older revision		Revision as of 13:28, 19 February 2020
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	* For those who do not, there is an incubation period of 3-5 years (with wide range) that is usually followed by indeterminate leprosy		* For those who do not, there is an incubation period of 3-5 years (with wide range) that is usually followed by indeterminate leprosy
	** Single, ill-defined, hypopigmented skin lesion		** Single, ill-defined, hypopigmented skin lesion
	** About 75% ~~sponetaneously~~ resolve, with the other 25% progressing		** About 75% spontaneously resolve, with the other 25% progressing
	* Classic presentation is anaesthetic hypopigmented skin lesion with thickened nerves		* Classic presentation is anaesthetic hypopigmented skin lesion with thickened nerves
			* Skin lesions can be: annular, asymmetric macules or plaques with central clearing and elevated borders (in tuberculoid) or symmetric, poorly-demarcated nodules and plaques or diffuse infiltration (lepromatous)
			** Lepromatous can also have xanthoma-likek or dermatofibroma-like lesions, leonine facies, and eyebrow alopecia

	=== Spectrum of disease ===		=== Spectrum of disease ===