Mycobacterium bovis (BCG strain) - Revision history

Aidan at 17:51, 22 October 2025

2025-10-22T17:51:27Z

← Older revision		Revision as of 17:51, 22 October 2025
Line 13:		Line 13:
	** Common symptoms are localized bladder irritation (dysuria, frequency, hematuria), with low-grade fevers and malaise		** Common symptoms are localized bladder irritation (dysuria, frequency, hematuria), with low-grade fevers and malaise
	* Systemic spread can cause a sepsis syndrome, pulmonary disease (miliary or interstitial disease), granulomatous hepatitis, osteomyelitis (most commonly the spine), psoas abscess, and (very rarely) vascular complications including arteritis or vasa vasorum or contiguous spread from local infection to the adjacent arteries		* Systemic spread can cause a sepsis syndrome, pulmonary disease (miliary or interstitial disease), granulomatous hepatitis, osteomyelitis (most commonly the spine), psoas abscess, and (very rarely) vascular complications including arteritis or vasa vasorum or contiguous spread from local infection to the adjacent arteries

			=== Local Post-Instillation Reaction ===

			* Can have malaise, myalgias, nausea, chills, and low-grade fevers that resolve within 48 hours

	== Management ==		== Management ==

Aidan at 17:47, 22 October 2025

2025-10-22T17:47:34Z

← Older revision		Revision as of 17:47, 22 October 2025
Line 3:		Line 3:
	== Background ==		== Background ==

	* Intravesicular instillation is used to treat bladder cancer		* Intravesicular instillation of ''Mycobacterium bovis'' BCG strain is sometimes used to treat bladder cancer
			* It can occasionally cause infections, sometimes referred to as BCGitis

	== Clinical Manifestations ==		== Clinical Manifestations ==
Line 12:		Line 13:
	** Common symptoms are localized bladder irritation (dysuria, frequency, hematuria), with low-grade fevers and malaise		** Common symptoms are localized bladder irritation (dysuria, frequency, hematuria), with low-grade fevers and malaise
	* Systemic spread can cause a sepsis syndrome, pulmonary disease (miliary or interstitial disease), granulomatous hepatitis, osteomyelitis (most commonly the spine), psoas abscess, and (very rarely) vascular complications including arteritis or vasa vasorum or contiguous spread from local infection to the adjacent arteries		* Systemic spread can cause a sepsis syndrome, pulmonary disease (miliary or interstitial disease), granulomatous hepatitis, osteomyelitis (most commonly the spine), psoas abscess, and (very rarely) vascular complications including arteritis or vasa vasorum or contiguous spread from local infection to the adjacent arteries

			== Management ==

			* Induction with [[isoniazid]], [[rifampin]], and [[ethambutol]], followed by consolidation with [[isoniazid]] and [[rifampin]]
			* Sometimes needs surgery

	[[Category:Mycobacteria]]		[[Category:Mycobacteria]]

Aidan at 16:13, 2 October 2025

2025-10-02T16:13:03Z

← Older revision		Revision as of 16:13, 2 October 2025
Line 1:		Line 1:
			{{DISPLAYTITLE:''Mycobacterium bovis'' (BCG strain)}}

	== Background ==		== Background ==

Aidan: Aidan moved page BCG infection to Mycobacterium bovis (BCG strain)

2025-10-02T16:12:49Z

Aidan moved page BCG infection to Mycobacterium bovis (BCG strain)

← Older revision	Revision as of 16:12, 2 October 2025
(No difference)

Aidan: Created page with "== Background == * Intravesicular instillation is used to treat bladder cancer == Clinical Manifestations == * Median time from instillation to onset of symptoms is Incubation period::169 daysCiteRef::cabas2021bc (range 3 months to many years) * Disease can disseminate to liver, lungs, bone marrow, bones, joints (in descending order of frequency) * Localized disease can cause cystitis, bladder contractures, granulomatous prostatitis, prostate abscess, epid..."

2025-10-02T16:12:06Z

Created page with "== Background == * Intravesicular instillation is used to treat bladder cancer == Clinical Manifestations == * Median time from instillation to onset of symptoms is Incubation period::169 days CiteRef::cabas2021bc (range 3 months to many years) * Disease can disseminate to liver, lungs, bone marrow, bones, joints (in descending order of frequency) * Localized disease can cause cystitis, bladder contractures, granulomatous prostatitis, prostate abscess, epid..."

New page

== Background ==

* Intravesicular instillation is used to treat bladder cancer

== Clinical Manifestations ==

* Median time from instillation to onset of symptoms is [[Incubation period::169 days]][[CiteRef::cabas2021bc]] (range 3 months to many years)
* Disease can disseminate to liver, lungs, bone marrow, bones, joints (in descending order of frequency)
* Localized disease can cause [[cystitis]], bladder contractures, granulomatous prostatitis, prostate abscess, epididymo-orchitis, testicular abscess, pyelonephritis, renal abscess, ureteral stricture, penile granuloma
** Common symptoms are localized bladder irritation (dysuria, frequency, hematuria), with low-grade fevers and malaise
* Systemic spread can cause a sepsis syndrome, pulmonary disease (miliary or interstitial disease), granulomatous hepatitis, osteomyelitis (most commonly the spine), psoas abscess, and (very rarely) vascular complications including arteritis or vasa vasorum or contiguous spread from local infection to the adjacent arteries

[[Category:Mycobacteria]]