https://idwiki.org/index.php?action=history&feed=atom&title=Methenamine 2026-05-13T00:11:57Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Methenamine&diff=6419&oldid=prev 2020-08-24T15:26:32Z

<p>Created page with &quot;== Background == * Indicated for the prevention of urinary tract infections === Mechanism of Action === * The prodrug is hydrolysed into formaldehyde and ammonia in acidic...&quot;</p> <p><b>New page</b></p><div>== Background ==<br /> <br /> * Indicated for the prevention of urinary tract infections<br /> <br /> === Mechanism of Action ===<br /> <br /> * The prodrug is hydrolysed into formaldehyde and ammonia in acidic urine<br /> <br /> === Spectrum of Activity ===<br /> <br /> * Active against essentially all bacteria and some fungi<br /> * Urease-positive organisms such as [[Proteus]] can inhibit its action by alkalinizing the urine and preventing the production of formaldehyde<br /> <br /> === Indications ===<br /> <br /> * Prophylaxis against urinary tract infection, especially in people without underlying urinary tract abnormalities<br /> * Levels of formaldehyde achieved in urine probably aren&#039;t high enough to treat active infection<br /> * No systemic antimicrobial activity<br /> <br /> == Dosing ==<br /> <br /> * Methenamine mandelate 1 g po QID (max 6 g daily)<br /> ** Add urine acidifying drugs like ammonium chloride, ascorbic acid, or methionine if urine pH is greater than 5.5<br /> * Methenamine hippurate 1 g PO bid<br /> ** Does not need urinary acidification<br /> <br /> == Adverse Drug Reactions ==<br /> <br /> * Nausea, vomiting, diarrhea<br /> * Pruritis and rash<br /> * Urinary tract irritation from formaldehyde, including dysuria, albuminuria, and hematuria<br /> * Gout flares<br /> * Rare elevations in liver enzymes<br /> <br /> [[Category:Antibiotics]]</div>

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