Malaria chemoprophylaxis - Revision history

Aidan at 14:22, 1 October 2020

2020-10-01T14:22:22Z

← Older revision		Revision as of 14:22, 1 October 2020
Line 1:		Line 1:
			== Background ==

	*Chemoprophylaxis is recommended for travelers to endemic areas		*Chemoprophylaxis is recommended for travelers to endemic areas
	*Agent chosen based on the local drug-resistance, patient age, and pregnancy status		*Agent chosen based on the local drug-resistance, patient age, and pregnancy status
			*Also need to focus on personal protective measures such as bed nets, long-sleeved clothing, and insect repellant

	==Chemoprophylaxis Selection==		==Chemoprophylaxis Selection==
	===Chloroquine-~~sensitive~~ ~~regions~~===		===Chloroquine-Sensitive Regions===

	*Regions include Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China		*Regions include Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China
Line 11:		Line 14:
	**Alternatives: [[atovaquone-proguanil]], [[doxycycline]], or [[mefloquine]]		**Alternatives: [[atovaquone-proguanil]], [[doxycycline]], or [[mefloquine]]

	===Chloroquine-~~resistant~~ ~~regions~~===		===Chloroquine-Resistant Regions===

	*Regions include most of sub-Saharan Africa, South America, Oceania and Asia		*Regions include most of sub-Saharan Africa, South America, Oceania and Asia
Line 22:		Line 25:
	**Alternatives: [[Primaquine]] (contraindicated in G6PD deficiency and pregnancy)		**Alternatives: [[Primaquine]] (contraindicated in G6PD deficiency and pregnancy)

	===Chloroquine-and ~~mefloquine~~-~~resistant~~ ~~regions~~===		===Chloroquine- and Mefloquine-Resistant Regions===

	*Regions include Asia, Africa and the Amazon basin, specifically in rural, wooded regions on the Thai borders with Myanmar, Cambodia, and Laos, as well as in southern Vietnam		*Regions include Asia, Africa and the Amazon basin, specifically in rural, wooded regions on the Thai borders with Myanmar, Cambodia, and Laos, as well as in southern Vietnam

Aidan: categories

2020-08-07T14:23:40Z

Aidan: /* Chemoprophylaxis Doses */

2020-04-30T01:15:30Z

Chemoprophylaxis Doses

← Older revision		Revision as of 01:15, 30 April 2020
Line 44:		Line 44:
	\| [[Mefloquine]] \|\| 250 mg po weekly \|\| 1-3 weeks before \|\| 4 weeks after		\| [[Mefloquine]] \|\| 250 mg po weekly \|\| 1-3 weeks before \|\| 4 weeks after
	\|-		\|-
	\| [[Primaquine]] \|\| 30 mg base po daily \|\| 1 day before \|\| 7 ~~days~~ after		\| [[Primaquine]] \|\| 30 mg base po daily \|\| 1 day before \|\| 1 week after
	\|-		\|-
	\| [[Chloroquine]] \|\| 300 mg po weekly \|\| 1 week before \|\| 4 weeks after		\| [[Chloroquine]] \|\| 300 mg po weekly \|\| 1 week before \|\| 4 weeks after

Aidan: /* Chemoprophylaxis Doses */

2020-04-30T01:15:09Z

Chemoprophylaxis Doses

← Older revision		Revision as of 01:15, 30 April 2020
Line 35:		Line 35:
	* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage		* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage

	{\| class="wikitable"		{\| class="wikitable sortable"
	! Medication !! Dose !! ~~Duration~~		! Medication !! Dose !! Start !! Stop
	\|-		\|-
	\| [[Atovaquone-proguanil]] \|\| 250 mg-100 mg po daily \|\| 1 day before to 1 week after		\| [[Atovaquone-proguanil]] \|\| 250 mg-100 mg po daily \|\| 1 day before \|\| 1 week after
	\|-		\|-
	\| [[Doxycycline]] \|\| 100 mg po daily \|\| 1 day before to 4 weeks after		\| [[Doxycycline]] \|\| 100 mg po daily \|\| 1 day before \|\| 4 weeks after
	\|-		\|-
	\| [[Mefloquine]] \|\| 250 mg po weekly \|\| 1-3 weeks before to 4 weeks after		\| [[Mefloquine]] \|\| 250 mg po weekly \|\| 1-3 weeks before \|\| 4 weeks after
	\|-		\|-
	\| [[Primaquine]] \|\| 30 mg base po daily \|\| 1 day before to 7 days after		\| [[Primaquine]] \|\| 30 mg base po daily \|\| 1 day before \|\| 7 days after
	\|-		\|-
	\| [[Chloroquine]] \|\| 300 mg po weekly \|\| 1 week before to 4 weeks after		\| [[Chloroquine]] \|\| 300 mg po weekly \|\| 1 week before \|\| 4 weeks after
	\|-		\|-
	\| [[Hydroxychloroquine]] \|\| 310 mg base po weekly \|\| 1 week before to 4 weeks after		\| [[Hydroxychloroquine]] \|\| 310 mg base po weekly \|\| 1 week before \|\| 4 weeks after
	\|}		\|}

Aidan at 22:12, 31 January 2020

2020-01-31T22:12:59Z

← Older revision		Revision as of 22:12, 31 January 2020
Line 2:		Line 2:
	* Agent chosen based on the local drug-resistance, patient age, and pregnancy status		* Agent chosen based on the local drug-resistance, patient age, and pregnancy status

			== Chemoprophylaxis Selection ==
	== Choice of Chemoprophylaxis ==
	=== Chloroquine-sensitive regions ===		=== Chloroquine-sensitive regions ===
	* Regions include Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China		* Regions include Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China
Line 32:		Line 32:
	* [[Atovaquone-proguanil]] may be considered after the first trimester		* [[Atovaquone-proguanil]] may be considered after the first trimester

	== Doses ==		== Chemoprophylaxis Doses ==
	* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage		* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage

Aidan: /* Medications */

2020-01-31T22:07:02Z

Medications

← Older revision		Revision as of 22:07, 31 January 2020
Line 32:		Line 32:
	* [[Atovaquone-proguanil]] may be considered after the first trimester		* [[Atovaquone-proguanil]] may be considered after the first trimester

	== ~~Medications~~ ==		== Doses ==
	* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage		* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage

Aidan at 22:06, 31 January 2020

2020-01-31T22:06:53Z

Aidan: Created page with "* Chemoprophylaxis is recommended for travelers to endemic areas * Agent chosen based on the local drug-resistance, patient age, and pregnancy status = Choice of Chemoprophyl..."

2020-01-31T22:06:19Z

Created page with "* Chemoprophylaxis is recommended for travelers to endemic areas * Agent chosen based on the local drug-resistance, patient age, and pregnancy status = Choice of Chemoprophyl..."

New page

* Chemoprophylaxis is recommended for travelers to endemic areas
* Agent chosen based on the local drug-resistance, patient age, and pregnancy status

= Choice of Chemoprophylaxis =
== Chloroquine-sensitive regions ==
* Regions include Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China
** See [https://www.canada.ca/en/public-health/services/travel-health/about-catmat/appendix-malaria-risk-recommended-chemoprophylaxis-geographic.html#tbl1 the CATMAT list] for specific countries
* Drugs of choice
** [[Chloroquine]] (Aralen) preferred, though [[hydroxychloroquine]] (Plaquenil) is also acceptable
** Alternatives: [[atovaquone-proguanil]], [[doxycycline]], or [[mefloquine]]

== Chloroquine-resistant regions ==
* Regions include most of sub-Saharan Africa, South America, Oceania and Asia
** See [https://www.canada.ca/en/public-health/services/travel-health/about-catmat/appendix-malaria-risk-recommended-chemoprophylaxis-geographic.html#tbl1 the CATMAT list] for specific countries
** Some areas of Thailand, Myanmar (Burma), Laos and Cambodia, and southern Vietnam are both chloroquine-resistant and mefloquine-resistant
* Drugs of choice
** [[Atovaquone-proguanil]]
** [[Doxycycline]]
** [[Mefloquine]]
** Alternatives: [[Primaquine]] (contraindicated in G6PD deficiency and pregnancy)

== Chloroquine-and mefloquine-resistant regions ==
* Regions include Asia, Africa and the Amazon basin, specifically in rural, wooded regions on the Thai borders with Myanmar, Cambodia, and Laos, as well as in southern Vietnam
* Drugs of choice
** [[Atovaquone-proguanil]]
** [[Doxycycline]]
** No approved drugs for pregnancy or children less than 5 kg, though [[atovaquone-proguanil]] may be considered after the first trimester

== Pregnancy ==
* [[Mefloquine]] can be used, if they cannot avoid travelling to malaria-endemic areas
** Can cause neuropsychiatric symptoms
* [[Atovaquone-proguanil]] may be considered after the first trimester

= Medication Doses =
* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage

{| class="wikitable"
! Medication !! Dose !! Duration
|-
| [[Atovaquone-proguanil]] || 250 mg-100 mg po daily || 1 day before to 1 week after
|-
| [[Doxycycline]] || 100 mg po daily || 1 day before to 4 weeks after
|-
| [[Mefloquine]] || 250 mg po weekly || 1-3 weeks before to 4 weeks after
|-
| [[Primaquine]] || 30 mg base po daily || 1 day before to 7 days after
|-
| [[Chloroquine]] || 300 mg po weekly || 1 week before to 4 weeks after
|-
| [[Hydroxychloroquine]] || 310 mg base po weekly || 1 week before to 4 weeks after
|}

[[Category:Protozoa]]

← Older revision		Revision as of 22:06, 31 January 2020
Line 2:		Line 2:
	* Agent chosen based on the local drug-resistance, patient age, and pregnancy status		* Agent chosen based on the local drug-resistance, patient age, and pregnancy status

	= Choice of Chemoprophylaxis =		== Choice of Chemoprophylaxis ==
	== Chloroquine-sensitive regions ==		=== Chloroquine-sensitive regions ===
	* Regions include Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China		* Regions include Haiti, the Dominican Republic, Central America north of the Panama Canal, parts of Mexico, parts of South America, north Africa, parts of the Middle East, and west/central China
	** See [https://www.canada.ca/en/public-health/services/travel-health/about-catmat/appendix-malaria-risk-recommended-chemoprophylaxis-geographic.html#tbl1 the CATMAT list] for specific countries		** See [https://www.canada.ca/en/public-health/services/travel-health/about-catmat/appendix-malaria-risk-recommended-chemoprophylaxis-geographic.html#tbl1 the CATMAT list] for specific countries
Line 10:		Line 10:
	** Alternatives: [[atovaquone-proguanil]], [[doxycycline]], or [[mefloquine]]		** Alternatives: [[atovaquone-proguanil]], [[doxycycline]], or [[mefloquine]]

	== Chloroquine-resistant regions ==		=== Chloroquine-resistant regions ===
	* Regions include most of sub-Saharan Africa, South America, Oceania and Asia		* Regions include most of sub-Saharan Africa, South America, Oceania and Asia
	** See [https://www.canada.ca/en/public-health/services/travel-health/about-catmat/appendix-malaria-risk-recommended-chemoprophylaxis-geographic.html#tbl1 the CATMAT list] for specific countries		** See [https://www.canada.ca/en/public-health/services/travel-health/about-catmat/appendix-malaria-risk-recommended-chemoprophylaxis-geographic.html#tbl1 the CATMAT list] for specific countries
Line 20:		Line 20:
	** Alternatives: [[Primaquine]] (contraindicated in G6PD deficiency and pregnancy)		** Alternatives: [[Primaquine]] (contraindicated in G6PD deficiency and pregnancy)

	== Chloroquine-and mefloquine-resistant regions ==		=== Chloroquine-and mefloquine-resistant regions ===
	* Regions include Asia, Africa and the Amazon basin, specifically in rural, wooded regions on the Thai borders with Myanmar, Cambodia, and Laos, as well as in southern Vietnam		* Regions include Asia, Africa and the Amazon basin, specifically in rural, wooded regions on the Thai borders with Myanmar, Cambodia, and Laos, as well as in southern Vietnam
	* Drugs of choice		* Drugs of choice
Line 27:		Line 27:
	** No approved drugs for pregnancy or children less than 5 kg, though [[atovaquone-proguanil]] may be considered after the first trimester		** No approved drugs for pregnancy or children less than 5 kg, though [[atovaquone-proguanil]] may be considered after the first trimester

	== Pregnancy ==		=== Pregnancy ===
	* [[Mefloquine]] can be used, if they cannot avoid travelling to malaria-endemic areas		* [[Mefloquine]] can be used, if they cannot avoid travelling to malaria-endemic areas
	** Can cause neuropsychiatric symptoms		** Can cause neuropsychiatric symptoms
	* [[Atovaquone-proguanil]] may be considered after the first trimester		* [[Atovaquone-proguanil]] may be considered after the first trimester

			== Medications ==
	= Medication Doses =
	* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage		* Note that the medications that require 4 weeks after end of exposure are extended in this way because they do not treat the liver stage