Lymphatic filariasis - Revision history

Aidan: Text replacement - " species]]" to "]]"

2022-02-01T11:02:59Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 11:02, 1 February 2022
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	=== Epidemiology ===		=== Epidemiology ===

	* Transmitted by various species of mosquitoes, including [[Vector::Anopheles ~~species~~]], [[Vector::Culex ~~species~~]], [[Vector::Aedes ~~species~~]], and [[Vector::Mansonia ~~species~~]]		* Transmitted by various species of mosquitoes, including [[Vector::Anopheles]], [[Vector::Culex]], [[Vector::Aedes]], and [[Vector::Mansonia]]
	* Present in Africa, Asia, Indian subcontinent, western Pacific Islands, areas in South and Central America, and the Caribbean (particularly Haiti and the Dominican Republic)		* Present in Africa, Asia, Indian subcontinent, western Pacific Islands, areas in South and Central America, and the Caribbean (particularly Haiti and the Dominican Republic)
	* [[Brugia malayi]] is present in India, Malaysia, and western Pacific islands including Indonesia and the Philippines		* [[Brugia malayi]] is present in India, Malaysia, and western Pacific islands including Indonesia and the Philippines
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	**Distal limb is involved in brugian filariasis		**Distal limb is involved in brugian filariasis
	*Progresses to elephantiasis over years		*Progresses to elephantiasis over years
	**Repeated episodes ADLA, burden of filariasis in the population, and presence of [[Wolbachia ~~species~~]] are risk factors for progression		**Repeated episodes ADLA, burden of filariasis in the population, and presence of [[Wolbachia]] are risk factors for progression
	*WHO grading		*WHO grading
	**Grade I: pitting edema that is reversible with elevation of the extremity		**Grade I: pitting edema that is reversible with elevation of the extremity

Aidan: /* Background */ added Epidemiology

2020-08-28T23:23:43Z

Background: added Epidemiology

Show changes

Aidan at 23:18, 28 August 2020

2020-08-28T23:18:22Z

← Older revision		Revision as of 23:18, 28 August 2020
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			== Background ==
⚫	* Mosquito-borne infection by filarial parasites causing chronic progressive lymphedema

		⚫	*Mosquito-borne infection by filarial parasites causing chronic progressive lymphedema
⚫	== Microbiology ==

		⚫	===Microbiology===
⚫	* ''[[Wuchereria bancrofti]]'' (most common, worldwide)

⚫	* ''[[Brugia malayi]]'' and ''[[Brugia timori]]'' (Asia)
		⚫	*''[[Wuchereria bancrofti]]'' (most common, worldwide)
		⚫	*''[[Brugia malayi]]'' and ''[[Brugia timori]]'' (Asia)

			== Clinical Manifestations ==

			=== Acute Manifestations ===

			==== Acute Filarial Lymphangitis ====

			* Pain, erythema, and tenderness in the regional lymph node, followed by lymphangitis that spreads distally
			* Caused by inflammation from the death of an adult worm

			==== Acute Dermatolymphangioadenitis ====

			* Bacterial infection of the small lymphatics causing fevers, chills, and pain
			* Often diagnosed as cellulitis, and can have a reticular pattern (compared to linear, in AFL)
			* May have history of preceding trauma or injury

			==== Brugian Adenolymphangitis ====

			* A single abscess along the lymphatics that can drain and scar

			==== Tropical Pulmonary Eosinophilia ====

			* Hypersensitivity response to the filaria migrating through the lungs
			* Mostly occurs in India but also Pakistan, Sri Lanka, Brazil, Guyana, and Southeast Asia
			* More common in men aged 20 to 40 years
			* Causes a paroxysmal non-productive cough, more severe at night (during microfilaremia), with wheezing, low-grade fever, adenopathy, malaise, and weight loss
			* Eosinophils usually very high, above 3, as well as high IgE titres and anti-filarial antibody titres
			* Chest x-ray can be normal or show diffuse small infiltrates with increased bronchovascular markings
			* Can progress to restrictive lung disease and diffuse interstitial fibrosis

			=== Chronic Manifestations ===

			==== Genital Manifestations ====

			* Only occur with [[Wuchereria bancrofti]]
			* Hydrocele, epididymitis, orchitis, funiculitis, lymphedema of the scrotum or vulva

			==== Lymphedema and Elephantiasis ====

			* Lymphedema in the legs, genitals, breast, arms
			* More common in the legs, and usually asymmetric
			** Whole limb is involved in bancroftian filariasis
			** Distal limb is involved in brugian filariasis
			* Progresses to elephantiasis over years
			** Repeated episodes ADLA, burden of filariasis in the population, and presence of [[Wolbachia species]] are risk factors for progression
			* WHO grading
			** Grade I: pitting edema that is reversible with elevation of the extremity
			** Grade II: non-pitting edema that is not reversible with elevation of the extremity
			** Grade III: non-pitting edema that is not reversible with elevation and is associated with thickened skin or skin folds
			** Grade IV: non-pitting edema with fibrotic and papillomatous skin lesions and the presence of skin folds (elephantiasis)

			==== Chyuria ====

			* Caused by rupture of retroperitoneal lymphatics into the renal pelvis
			* Painless

	[[Category:Nematodes]]		[[Category:Nematodes]]

Aidan: /* Microbiology */

2019-12-16T15:25:33Z

Microbiology

← Older revision		Revision as of 15:25, 16 December 2019
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	== Microbiology ==		== Microbiology ==

	* ''Wuchereria bancrofti'' (most common, ~~worldwise~~)		* ''[[Wuchereria bancrofti]]'' (most common, worldwide)
	* ''Brugia malayi'' and ''Brugia timori'' (Asia)		* ''[[Brugia malayi]]'' and ''[[Brugia timori]]'' (Asia)

	[[Category:Nematodes]]		[[Category:Nematodes]]

Aidan at 11:51, 16 August 2019

2019-08-16T11:51:40Z

← Older revision		Revision as of 11:51, 16 August 2019
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	= Lymphatic filariasis =

	* Mosquito-borne infection by filarial parasites causing chronic progressive lymphedema		* Mosquito-borne infection by filarial parasites causing chronic progressive lymphedema

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	* ''Wuchereria bancrofti'' (most common, worldwise)		* ''Wuchereria bancrofti'' (most common, worldwise)
	* ''Brugia malayi'' and ''Brugia timori'' (Asia)		* ''Brugia malayi'' and ''Brugia timori'' (Asia)

			[[Category:Nematodes]]

Aidan: Aidan moved page Skin and soft tissue Lymphatic filariasis to Lymphatic filariasis without leaving a redirect

2019-08-16T11:51:14Z

Aidan moved page Skin and soft tissue Lymphatic filariasis to Lymphatic filariasis without leaving a redirect

← Older revision		Revision as of 11:51, 16 August 2019
(No difference)

Maintenance script: Imported from text file

2019-08-11T18:05:58Z

Imported from text file

New page

= Lymphatic filariasis =

* Mosquito-borne infection by filarial parasites causing chronic progressive lymphedema

== Microbiology ==

* ''Wuchereria bancrofti'' (most common, worldwise)
* ''Brugia malayi'' and ''Brugia timori'' (Asia)