Linezolid - Revision history

Aidan: /* Dosing */

2025-08-11T21:31:42Z

Dosing

← Older revision		Revision as of 21:31, 11 August 2025
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	== Dosing ==		== Dosing ==

	* ~~Linezolid~~ 600 mg PO/IV q12h		* Usual: 600 mg PO/IV q12h
			* Tuberculosis: 600 mg p.o. daily

	=== Renal Dosing ===		=== Renal Dosing ===

Aidan at 17:05, 27 September 2024

2024-09-27T17:05:48Z

← Older revision		Revision as of 17:05, 27 September 2024
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	* The generally-recommended maximum therapy is 28 days		* The generally-recommended maximum therapy is 28 days
	* However, linezolid is used in the treatment for [[MDR-TB]] in much longer courses		* However, linezolid is used in the treatment for [[MDR-TB]] in much longer courses
			* The most common adverse effects were [[peripheral neuropathy]] (64%), myelosuppression (22%), optic neuritis (5%), GI effects (2%), and rash (2%)[[CiteRef::lan2020dr]]
	* The most common adverse effects were [[peripheral neuropathy]] (64%), myelosuppression (22%), optic neuritis (5%), GI effects (2%), and rash (2%)<ref>Lan Z, Ahmad N, Baghaei P, Barkane L, Benedetti A, Brode SK, Brust JCM, Campbell JR, Chang VWL, Falzon D, Guglielmetti L, Isaakidis P, Kempker RR, Kipiani M, Kuksa L, Lange C, Laniado-Laborín R, Nahid P, Rodrigues D, Singla R, Udwadia ZF, Menzies D; Collaborative Group for the Meta-Analysis of Individual Patient Data in MDR-TB treatment 2017. Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet Respir Med. 2020 Apr;8(4):383-394. doi: [https://doi.org/10.1016/S2213-2600(20)30047-3 10.1016/S2213-2600(20)30047-3]. Epub 2020 Mar 17. PMID: 32192585; PMCID: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384398/ PMC7384398].</ref>
	* About 15% of patients had to permanently discontinue due to adverse effects		* About 15% of patients had to permanently discontinue due to adverse effects
			* Risk of adverse reactions increases with time[[CiteRef::migliori2009a]]
	* Risk of adverse reactions increases with time<ref>Migliori GB, Eker B, Richardson MD, Sotgiu G, Zellweger JP, Skrahina A, Ortmann J, Girardi E, Hoffmann H, Besozzi G, Bevilacqua N, Kirsten D, Centis R, Lange C; TBNET Study Group. A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis. Eur Respir J. 2009 Aug;34(2):387-93. doi: [https://doi.org/10.1183/09031936.00009509 10.1183/09031936.00009509]. Epub 2009 Mar 12. PMID: [https://pubmed.ncbi.nlm.nih.gov/19282348/ 19282348].</ref>
	** <10% at 2 weeks (for higher, standard dose)		** <10% at 2 weeks (for higher, standard dose)
	** 12% at 4 weeks		** 12% at 4 weeks

Aidan at 18:13, 18 September 2022

2022-09-18T18:13:07Z

@@ Line 16: / Line 16: @@
 * Linezolid 600 mg PO/IV q12h
-== Adverse Drug Reactions ==
+=== Renal Dosing ===
 * [[Adverse drug reaction::Serotonin syndrome|Serotonin syndrome]] when taken concurrently with certain psychiatric medications
 ** Ideally hold SSRIs when starting linezolid
 * Cytopenias, including [[Adverse drug reaction::Thrombocytopenia|thrombocytopenia]] (most common), [[Adverse drug reaction::anemia]], and [[Adverse drug reaction::leukopenia]] (least common)
 ** More common with prolonged use, e.g. after 2 weeks
 [[Category:Antibiotics]]

Aidan at 17:47, 22 August 2020

2020-08-22T17:47:58Z

← Older revision		Revision as of 17:47, 22 August 2020
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	* Cytopenias, including [[Adverse drug reaction::Thrombocytopenia\|thrombocytopenia]] (most common), [[Adverse drug reaction::anemia]], and [[Adverse drug reaction::leukopenia]] (least common)		* Cytopenias, including [[Adverse drug reaction::Thrombocytopenia\|thrombocytopenia]] (most common), [[Adverse drug reaction::anemia]], and [[Adverse drug reaction::leukopenia]] (least common)
	** More common with prolonged use, e.g. after 2 weeks		** More common with prolonged use, e.g. after 2 weeks

			[[Category:Antibiotics]]

Aidan: Created page with "== Background == * Oxazolidinone antibiotic === Mechanism of Action === * Inhibits the 50S ribosome of Gram-positive bacteria === Spectrum of Activity === * Active agains..."

2020-08-22T17:47:48Z

Created page with "== Background == * Oxazolidinone antibiotic === Mechanism of Action === * Inhibits the 50S ribosome of Gram-positive bacteria === Spectrum of Activity === * Active agains..."

New page

== Background ==

* Oxazolidinone antibiotic

=== Mechanism of Action ===

* Inhibits the 50S ribosome of Gram-positive bacteria

=== Spectrum of Activity ===

* Active against [[Gram-positive bacteria]]
* Not active against [[Gram-negative bacteria]]

== Dosing ==

* Linezolid 600 mg PO/IV q12h

== Adverse Drug Reactions ==

* [[Adverse drug reaction::Serotonin syndrome|Serotonin syndrome]] when taken concurrently with certain psychiatric medications
** Ideally hold SSRIs when starting linezolid
* Cytopenias, including [[Adverse drug reaction::Thrombocytopenia|thrombocytopenia]] (most common), [[Adverse drug reaction::anemia]], and [[Adverse drug reaction::leukopenia]] (least common)
** More common with prolonged use, e.g. after 2 weeks