Letermovir - Revision history

Aidan at 10:43, 3 September 2020

2020-09-03T10:43:49Z

← Older revision		Revision as of 10:43, 3 September 2020
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			== Background ==
⚫	* Antiviral that targets subunit 2 of the viral terminase complex (UL56) in [[cytomegalovirus]]

	* Oral and intravenous
			=== Mechanism of Action ===
⚫	* Increases bioavailability of [[cyclosporine]]

⚫	* No ~~renal~~ adjustment needed
		⚫	*Antiviral that targets subunit 2 of the viral terminase complex (UL56) in [[cytomegalovirus]]
⚫	* Indications: {{#ask: [[Is treated by::letermovir]] \| default=none}}

⚫	** No activity against [[HSV]] or [[VZV]]
			=== Spectrum of Activity ===

		⚫	*Indications: {{#ask: [[Is treated by::letermovir]] \| default=none}}
		⚫	*No activity against [[HSV]] or [[VZV]]

			== Dosing ==

			* Letermovir 480 mg IV/PO q24h, infused over 1 hour
			* If concomitant [[cyclosporine]], decrease dose to 240 mg IV/PO q24h

			=== Renal Dosing ===

		⚫	* No dose adjustment needed as long as CrCl >10 mL/min

			== Safety ==

			=== Adverse Drug Reaction ===

			* Nausea, vomiting, diarrhea, cough, headache, peripheral edema

			=== Drug-Drug Interactions ===

		⚫	*Increases bioavailability of [[cyclosporine]]
			*Decreases concentration of [[voriconazole]]
			*Concentration of letermovir is increased by [[atorvastatin]], [[sirolimus]], and [[tacrolimus]]

	[[Category:Antivirals]]		[[Category:Antivirals]]

Aidan at 14:22, 24 October 2019

2019-10-24T14:22:59Z

← Older revision		Revision as of 14:22, 24 October 2019
Line 1:		Line 1:
			* Antiviral that targets subunit 2 of the viral terminase complex (UL56) in [[cytomegalovirus]]
	* Antiviral
	* Oral and intravenous		* Oral and intravenous
	* Increases bioavailability of [[cyclosporine]]		* Increases bioavailability of [[cyclosporine]]
	* No renal adjustment needed		* No renal adjustment needed
	* Indications: {{#ask: [[Is treated by::letermovir]] \| default=none}}		* Indications: {{#ask: [[Is treated by::letermovir]] \| default=none}}
			** No activity against [[HSV]] or [[VZV]]

	[[Category:Antivirals]]		[[Category:Antivirals]]

Aidan: Created page with "* Antiviral * Oral and intravenous * Increases bioavailability of cyclosporine * No renal adjustment needed * Indications: {{#ask: Is treated by::letermovir | default=..."

2019-10-24T14:21:07Z

Created page with "* Antiviral * Oral and intravenous * Increases bioavailability of cyclosporine * No renal adjustment needed * Indications: {{#ask: Is treated by::letermovir | default=..."

New page

* Antiviral
* Oral and intravenous
* Increases bioavailability of [[cyclosporine]]
* No renal adjustment needed
* Indications: {{#ask: [[Is treated by::letermovir]] | default=none}}

[[Category:Antivirals]]