Lentivirus humimdef1 - Revision history

Aidan at 14:09, 3 February 2025

2025-02-03T14:09:42Z

← Older revision		Revision as of 14:09, 3 February 2025
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			{{DISPLAYTITLE:''Lentivirus humimdef1''}}

	==Background==		==Background==

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	===Microbiology===		===Microbiology===

	*A member of the Retroviridae family		*A member of the [[Family::Retroviridae]] family
	*Clades or subtypes:		*Clades or subtypes:
	**HIV-1: by far the most common species worldwide		**HIV-1: by far the most common species worldwide

Aidan: Aidan moved page Human immunodeficiency virus to Lentivirus humimdef1 over redirect: new binomial nomenclature

2025-02-03T14:09:11Z

Aidan moved page Human immunodeficiency virus to Lentivirus humimdef1 over redirect: new binomial nomenclature

← Older revision	Revision as of 14:09, 3 February 2025
(No difference)

Aidan at 14:32, 22 October 2020

2020-10-22T14:32:32Z

Show changes

Aidan at 01:52, 22 October 2020

2020-10-22T01:52:25Z

Show changes

Aidan: /* Diagnosis */

2020-09-24T13:01:08Z

Diagnosis

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 * '''HIV serology'''
 ** Can test for HIV antibodies (usually combined IgM/IgG) and p24 antigen
-** Window period of 3-4 weeks exists before antibodies are positive, and is shortened to 2-3 weeks with antigen testing
+** Window period of 3-4 weeks exists before antibodies are positive, and is shortened to 2-3 weeks with antigen testing (included in fourth-generation testing)
 ** If concern for acute seroconversion syndrome (within 2-4 weeks of exposure), may need to repeat serology
 ** Standard testing in Ontario includes HIV 1+2 antigen/antibody ELISA screen, followed by confirmatory p24 antigen ELISA
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 ! Ab/Ag !! Ab !! Ag !! RNA !! Interpretation
 |-
 |-
 |-
 |-
 |}

Aidan: /* Acute HIV */

2020-08-05T14:00:00Z

Acute HIV

← Older revision		Revision as of 14:00, 5 August 2020
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	==Clinical Manifestations==		==Clinical Manifestations==
	===Acute HIV===		===Acute HIV===
	* Incubation period 2 to 6 weeks		* Incubation period [[Usual incubation period::2 to 6 weeks]]
	* Usually presents as an influenza-like illness		* Usually presents as an influenza-like illness
	* Symptoms include [[Has symptom::fever]], [[Has symptom::lymphadenopathy]], [[Has symptom::rash]], [[Has symptom::myalgias]], [[Has symptom::arthralgias]], [[Has symptom::headache]], [[Has symptom::diarrhea]], [[Has symptom::oral ulcers]], [[Has symptom::leukopenia]], [[Has symptom::thrombocytopenia]], and mild [[Has symptom::hepatitis]]		* Symptoms include [[Has symptom::fever]], [[Has symptom::lymphadenopathy]], [[Has symptom::rash]], [[Has symptom::myalgias]], [[Has symptom::arthralgias]], [[Has symptom::headache]], [[Has symptom::diarrhea]], [[Has symptom::oral ulcers]], [[Has symptom::leukopenia]], [[Has symptom::thrombocytopenia]], and mild [[Has symptom::hepatitis]]

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-21T01:52:52Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 01:52, 21 July 2020
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	* Prior STIs		* Prior STIs

	==Clinical ~~Presentation~~==		==Clinical Manifestations==
	===Acute HIV===		===Acute HIV===
	* Incubation period 2 to 6 weeks		* Incubation period 2 to 6 weeks

Aidan: /* Microbiology */

2020-06-20T15:05:50Z

Microbiology

← Older revision		Revision as of 15:05, 20 June 2020
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	===Microbiology===		===Microbiology===
	* A member of the Retroviridae family		* A member of the Retroviridae family
			* Clades or subtypes:

		⚫	** HIV-1
	====Clades / Subtypes====
		⚫	*** M group
⚫	* HIV-1
		⚫	**** Clade A: common in East Africa
⚫	** M group
	*** Clade A: common in ~~East~~ ~~Africa~~		**** Clade B: is common in Canada, Americas, Europe
		⚫	** HIV-2
⚫	*** Clade B: is common in ~~Canada, Americas,~~ ~~Europe~~
⚫	* HIV-2

	===Life Cycle===		===Life Cycle===

Aidan at 15:04, 20 June 2020

2020-06-20T15:04:52Z

← Older revision		Revision as of 15:04, 20 June 2020
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	* A chronic immunodeficiency resulting from infection with the human immunodeficiency virus (HIV)		* A chronic immunodeficiency resulting from infection with the human immunodeficiency virus (HIV)
	* Acquired immune deficiency syndrome (AIDS) is a severe form of HIV characterized by low CD4 count resulting in characteristic infections		* Acquired immune deficiency syndrome (AIDS) is a severe form of HIV characterized by low CD4 count resulting in characteristic infections
			==Background==

	== Microbiology ==		===Microbiology===

	* A member of the Retroviridae family		* A member of the Retroviridae family

	=== Clades / Subtypes ===		====Clades / Subtypes====

	* HIV-1		* HIV-1
	** M group		** M group
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	* HIV-2		* HIV-2

	== Life Cycle ==		===Life Cycle===

	* Two phases: initial viral attachment, fusion, reverse transcription, and integration; and the following lifetime of the viral infection		* Two phases: initial viral attachment, fusion, reverse transcription, and integration; and the following lifetime of the viral infection
	* Initial cellular infection		* Initial cellular infection
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	* HIV enters from the mucosa to infect activated Langerhans macrophages, which then get to the local lymphoid tissue		* HIV enters from the mucosa to infect activated Langerhans macrophages, which then get to the local lymphoid tissue

	== Epidemiology ==		===Epidemiology===

	* 63,000 Canadians living with HIV in 2016		* 63,000 Canadians living with HIV in 2016
	* 14% don't know they have it		* 14% don't know they have it
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	** Heterosexual sex (33% of cases)		** Heterosexual sex (33% of cases)

	== Risk Factors ==		===Risk Factors===

	* High-risk exposures		* High-risk exposures
	** MSM		** MSM
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	* Prior STIs		* Prior STIs

	== Presentation ==		==Clinical Presentation==
		⚫	===Acute HIV===

⚫	=== Acute HIV~~/Seroconverion~~ ===
	* Incubation period 2 to 6 weeks		* Incubation period 2 to 6 weeks
	* Usually presents as an influenza-like illness		* Usually presents as an influenza-like illness
	* Symptoms include [[Has symptom::fever]], [[Has symptom::lymphadenopathy]], [[Has symptom::rash]], [[Has symptom::myalgias]], [[Has symptom::arthralgias]], [[Has symptom::headache]], [[Has symptom::diarrhea]], [[Has symptom::oral ulcers]], [[Has symptom::leukopenia]], [[Has symptom::thrombocytopenia]], and mild [[Has symptom::hepatitis]]		* Symptoms include [[Has symptom::fever]], [[Has symptom::lymphadenopathy]], [[Has symptom::rash]], [[Has symptom::myalgias]], [[Has symptom::arthralgias]], [[Has symptom::headache]], [[Has symptom::diarrhea]], [[Has symptom::oral ulcers]], [[Has symptom::leukopenia]], [[Has symptom::thrombocytopenia]], and mild [[Has symptom::hepatitis]]

	=== Chronic HIV ===		===Chronic HIV===
	* Fevers		* Fevers
	* Weight loss		* Weight loss
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	* [[Opportunistic infections in HIV\|Opportunistic infections]]		* [[Opportunistic infections in HIV\|Opportunistic infections]]

	== Diagnosis ==		==Diagnosis==

	* '''HIV serology'''		* '''HIV serology'''
	** Can test for HIV antibodies (usually combined IgM/IgG) and p24 antigen		** Can test for HIV antibodies (usually combined IgM/IgG) and p24 antigen
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	\|}		\|}

	== Investigations ==		==Investigations==

	* See [[Initial assessment for patients with HIV]] for baseline bloodwork		* See [[Initial assessment for patients with HIV]] for baseline bloodwork

	== Management ==		==Management==
		⚫	===Initial management===

⚫	=== Initial management ===

	* [[Initial assessment for patients with HIV]]		* [[Initial assessment for patients with HIV]]
	* [[Single-tablet regimens for HIV]]		* [[Single-tablet regimens for HIV]]
	* [[HIV treatment]]		* [[HIV treatment]]

	=== Follow-up ===		===Follow-up===

	* See also [[Routine follow-up for patients with HIV]]		* See also [[Routine follow-up for patients with HIV]]
	* HIV viral load		* HIV viral load

Aidan: /* Diagnosis */ clarified window period in table

2020-01-22T02:22:03Z

Diagnosis: clarified window period in table

← Older revision		Revision as of 02:22, 22 January 2020
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	! Ab/Ag !! Ab !! Ag !! RNA !! Interpretation		! Ab/Ag !! Ab !! Ag !! RNA !! Interpretation
	\|-		\|-
	\| – \|\| \|\| \|\| \|\| HIV negative, or window period ~~if within~~ 2-3 weeks ~~of exposure~~		\| – \|\| \|\| \|\| \|\| HIV negative, or within serologic window period (2-3 weeks)
	\|-		\|-
	\| – \|\| \|\| \|\| + \|\| HIV positive ~~(window~~ ~~period~~ up to 2-3 weeks)		\| – \|\| \|\| \|\| + \|\| HIV positive, within the serologic window period (2-3 weeks)
	\|-		\|-
	\| + \|\| + \|\| \|\| \|\| HIV positive (following 3-4 week window period)		\| + \|\| + \|\| \|\| \|\| HIV positive, following a 3-4 week window period
	\|-		\|-
	\| + \|\| – \|\| + \|\| \|\| HIV positive (window period up to 3-4 weeks)		\| + \|\| – \|\| + \|\| \|\| HIV positive, within the serologic window period for antibodies (3-4 weeks)
	\|}		\|}