Aidan: Text replacement - " species]]" to "]]"

2022-02-09T08:37:18Z

Text replacement - " species]]" to "]]"

← Older revision		Revision as of 08:37, 9 February 2022
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	** Endemic in Guinea, Sierra Leone, Liberia, and Nigeria		** Endemic in Guinea, Sierra Leone, Liberia, and Nigeria
	** In Sierra Leone and Liberia, up to 10-15% of hospital admission are due to Lassa fever		** In Sierra Leone and Liberia, up to 10-15% of hospital admission are due to Lassa fever
	* Reservoir is [[Reservoir::Mastomys ~~species~~]] multimammate mouse, as well as African wood mouse		* Reservoir is [[Reservoir::Mastomys]] multimammate mouse, as well as African wood mouse
	* Associated with bush meat hunting		* Associated with bush meat hunting
	* 59 million people at risk with up to 3 million cases annually causing 67,000 deaths		* 59 million people at risk with up to 3 million cases annually causing 67,000 deaths

Aidan: Created page with "== Background == === Microbiology === * Negative-sense, single-stranded RNA virus within the Arenaviridae family * Genome in small (S) and large (L) segments * Covered i..."

2020-08-28T13:54:00Z

Created page with "== Background == === Microbiology === * Negative-sense, single-stranded RNA virus within the Arenaviridae family * Genome in small (S) and large (L) segments * Covered i..."

New page

== Background ==

=== Microbiology ===

* Negative-sense, single-stranded RNA virus within the [[Arenaviridae]] family
* Genome in small (S) and large (L) segments
* Covered in glycoprotein spikes, and cell ribosomes are visible inside

=== Epidemiology ===

* West Africa, particulary in Guinea, Sierra Leone, Liberia, Mali, Côte d'Ivoire, Ghana, Togo, Benin, Burkina Faso, and Nigeria
** Endemic in Guinea, Sierra Leone, Liberia, and Nigeria
** In Sierra Leone and Liberia, up to 10-15% of hospital admission are due to Lassa fever
* Reservoir is [[Reservoir::Mastomys species]] multimammate mouse, as well as African wood mouse
* Associated with bush meat hunting
* 59 million people at risk with up to 3 million cases annually causing 67,000 deaths
* More common in dry season when the rats are more likely to search to food within human habitats

== Clinical Manifestations ==

* Incubation period [[Usual incubation period::up to 21 days]]
* Wide range of severity
** Likely 30 asymptomatic or very mild cases for every symptomatic case
** Mild symptoms in 80% of cases
* Hearing loss in 30%, which can be permanent
* Unlike other [[viral hemorrhagic fevers]], subcutaneous bleeding and rash is uncommon
* Facial edema has been described
* Seizures in encephalopathy
* Mortality about 1%, but up to 65% in hospitalized patients

== Diagnosis ==

* National Microbiology Lab can do PCR, virus isolation, and serology
** Peak viremia 4 to 9 days after symptom onset, so may need to retest
* Rapid antigen test Corgenix ReLASV, not licensed in Canada
* Co-endemic with malaria and typhoid so test for those as well

== Management ==

* Supportive care with IV fluids and electrolytes as necessary
* Avoid NSAIDs due to bleeding risk
* [[Ribavirin]] may be helpful especially early in disease, per WHO
* Experimental medications include [[favipiravir]]

== Prevention ==

=== Infection Prevention and Control ===

* Isolate patient
* Droplet and contact precautions, with gloves, gown, and eye protection

[[Category:Arenaviridae]]

Lassa virus - Revision history

Aidan: Text replacement - " species]]" to "]]"

Aidan: Created page with "== Background == === Microbiology === * Negative-sense, single-stranded RNA virus within the Arenaviridae family * Genome in small (S) and large (L) segments * Covered i..."