Klebsiella pneumoniae subspecies rhinoscleromatis - Revision history

Aidan at 16:32, 13 January 2026

2026-01-13T16:32:09Z

← Older revision		Revision as of 16:32, 13 January 2026
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	* Fungal infections		* Fungal infections
	* [[Granolumatosis with polyangiitis]]		* [[Granolumatosis with polyangiitis]]
			* Malignancy, including less commonly [[T cell lymphoma]] and [[basal cell carcinoma]]
	* Malignancies of head and neck
	* [[Sarcoidosis]]		* [[Sarcoidosis]]

Aidan at 16:26, 13 January 2026

2026-01-13T16:26:59Z

← Older revision		Revision as of 16:26, 13 January 2026
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	== Background ==		== Background ==
			* Causative organism of '''rhinoscleroma''', a chronic granulomatous disease of nasal and respiratory tract
		⚫	* Also known as '''respiratory scleroma'''

	=== Microbiology ===		=== Microbiology ===
	* ~~A chronic granulomatous disease~~ of ~~nasal~~ ~~and~~ ~~respiratory~~ ~~tract~~ ~~caused~~ ~~by ''~~[[~~Is caused by~~::Klebsiella pneumoniae]]~~'' subspecies ''rhinoscleromatis''~~		* Subspecies of [[Stain::Gram-negative]] [[Shape::bacillus]] within the species [[Species::Klebsiella pneumoniae]]
⚫	* Also known as respiratory scleroma

	=== Epidemiology ===		=== Epidemiology ===
			* Not found outside of human hosts
	* Primarily found in developing countries worldwide, in particular Mexico, Central America, and the Middle East		* Primarily found in developing countries worldwide, in particular Mexico, Central America, and the Middle East
	* Transmitted by close contact		* Transmitted by close contact

	== Clinical Manifestations ==		== Clinical Manifestations ==
			* Non-specific early symptoms make it a challenging diagnosis
			* Causes chronic inflammation of the nasal pathways and other parts of respiratory tract
			* Starts with atrophic stage followed by granulomatous stage and finally fibrotic stage
			* By the time it is diagnosed, it is often already quite disfiguring, with airway compromise
	* Presents with nodules or masses in the nasal passages or other parts of the naso- or oropharynx or respiratory tract		* Presents with nodules or masses in the nasal passages or other parts of the naso- or oropharynx or respiratory tract
			* Can occasionally erode through bone to cause CNS infections

			== Differential Diagnosis ==
			* [[Tuberculosis]]
			* [[Leprosy]]
			* Fungal infections
			* [[Granolumatosis with polyangiitis]]
			* Malignancies of head and neck
			* [[Sarcoidosis]]

	== Diagnosis ==		== Diagnosis ==
	* Biopsy shows granulomatous inflammation with foamy macrophages		* Biopsy shows granulomatous inflammation with foamy macrophages (known as Mikulicz cells), which contain intracellular bacteria
			* Grow in routine culture

	== Manageemnt ==		== Manageemnt ==
	* Treated with 6 to 8 weeks of antibiotics, but high relapse rate		* Treated with 6 to 8 weeks of antibiotics (or longer), with or without surgical debridement, but high relapse rate
			* Traditionally treated with [[streptomycin]] or [[tetracycline]]; more recently, may be treated with [[co-trimoxazole]] or [[[fluoroquinolones]]

	[[Category:Head and neck infections]]		[[Category:Head and neck infections]]

Aidan at 16:19, 13 January 2026

2026-01-13T16:19:39Z

← Older revision		Revision as of 16:19, 13 January 2026
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			{{DISPLAYTITLE:''Klebsiella pneumoniae'' subspecies ''rhinoscleromatis''}}

	== Background ==		== Background ==

Aidan: Aidan moved page Rhinoscleroma to Klebsiella pneumoniae subspecies rhinoscleromatis

2026-01-13T16:19:21Z

Aidan moved page Rhinoscleroma to Klebsiella pneumoniae subspecies rhinoscleromatis

← Older revision		Revision as of 16:19, 13 January 2026
(No difference)

Aidan at 16:19, 13 January 2026

2026-01-13T16:19:08Z

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 * A chronic granulomatous disease of nasal and respiratory tract caused by ''[[Is caused by::Klebsiella pneumoniae]]'' subspecies ''rhinoscleromatis''
 * Transmitted by close contact
 * Presents with nodules or masses in the nasal passages or other parts of the naso- or oropharynx or respiratory tract
 * Biopsy shows granulomatous inflammation with foamy macrophages
 * Treated with 6 to 8 weeks of antibiotics, but high relapse rate

Aidan: Created page with "* A chronic granulomatous disease of nasal and respiratory tract caused by ''Is caused by::Klebsiella pneumoniae'' subspecies ''rhinoscleromatis'' * Primarily found in dev..."

2020-02-13T22:04:52Z

Created page with "* A chronic granulomatous disease of nasal and respiratory tract caused by ''Is caused by::Klebsiella pneumoniae'' subspecies ''rhinoscleromatis'' * Primarily found in dev..."

New page

* A chronic granulomatous disease of nasal and respiratory tract caused by ''[[Is caused by::Klebsiella pneumoniae]]'' subspecies ''rhinoscleromatis''
* Primarily found in developing countries worldwide
* Transmitted by close contact
* Presents with nodules or masses in the nasal passages or other parts of the naso- or oropharynx or respiratory tract
* Biopsy shows granulomatous inflammation with foamy macrophages
* Treated with 6 to 8 weeks of antibiotics, but high relapse rate

[[Category:Head and neck infections]]