https://idwiki.org/index.php?action=history&feed=atom&title=Ketamine 2026-05-13T04:21:56Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Ketamine&diff=8132&oldid=prev 2021-11-02T12:55:37Z

<p><span class="autocomment">Dosing</span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:55, 2 November 2021</td> </tr><tr> <td colspan="2" class="diff-lineno">Line 9:</td> <td colspan="2" class="diff-lineno">Line 9:</td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Analgesia[[CiteRef::silverstein2021ke]]</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Analgesia[[CiteRef::silverstein2021ke]]</div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>** Intermittent: <del style="font-weight: bold; text-decoration: none;">0.1</del> <del style="font-weight: bold; text-decoration: none;">to</del> 0.<del style="font-weight: bold; text-decoration: none;">3</del> mg/kg IV q4h (max 0.35 mg/kg<del style="font-weight: bold; text-decoration: none;">(</del></div></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>** Intermittent: <ins style="font-weight: bold; text-decoration: none;">start</ins> <ins style="font-weight: bold; text-decoration: none;">at</ins> 0.<ins style="font-weight: bold; text-decoration: none;">1</ins> mg/kg IV q4h<ins style="font-weight: bold; text-decoration: none;">, and titrate</ins> (max 0.35 mg/kg<ins style="font-weight: bold; text-decoration: none;">)</ins></div></td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>** Continuous infusion: 0.1 mg/kg/h IV infusion (max 0.25 mg/kg/h)</div></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>** Continuous infusion:<ins style="font-weight: bold; text-decoration: none;"> start at</ins> 0.1 mg/kg/h IV infusion<ins style="font-weight: bold; text-decoration: none;">, and titrate</ins> (max 0.25 mg/kg/h)</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Dissociative anesthesia: ≥1 mg/kg</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Dissociative anesthesia: ≥1 mg/kg</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> </table>

Aidan https://idwiki.org/index.php?title=Ketamine&diff=8129&oldid=prev 2021-11-02T12:52:07Z

<p>Created page with &quot;== Background == * <a href="/index.php?title=Phencyclidine&amp;action=edit&amp;redlink=1" class="new" title="Phencyclidine (page does not exist)">Phencyclidine</a> (PCP) derivative * Inhibits NMDA (N-methyl-d-aspartate) receptors * Dose-dependent effects: low doses are primarily analgesic, while high...&quot;</p> <p><b>New page</b></p><div>== Background ==<br /> <br /> * [[Phencyclidine]] (PCP) derivative<br /> * Inhibits NMDA (N-methyl-d-aspartate) receptors<br /> * Dose-dependent effects: low doses are primarily analgesic, while high doses cause dissociative anesthesia<br /> ** When used for management of acute pain, can be opioid-sparing<br /> <br /> == Dosing ==<br /> <br /> * Analgesia[[CiteRef::silverstein2021ke]]<br /> ** Intermittent: 0.1 to 0.3 mg/kg IV q4h (max 0.35 mg/kg(<br /> ** Continuous infusion: 0.1 mg/kg/h IV infusion (max 0.25 mg/kg/h)<br /> * Dissociative anesthesia: ≥1 mg/kg<br /> <br /> === Hepatic Dosing ===<br /> <br /> * Avoid in liver dysfunction<br /> <br /> == Safety ==<br /> <br /> * Avoid in patients with psychosis, severe cardiovascular disease, or liver dysfunction<br /> <br /> === Adverse Effects ===<br /> <br /> * Primarily dose-dependent, with nausea, vomiting, vivid dreams, hallucinations, and dissociation seen at high doses<br /> <br /> === Pregnancy ===<br /> <br /> * Unclear safety in pregnancy<br /> <br /> [[Category:Medications]]<br /> [[Category:Anaesthesia]]</div>

Aidan