John Cunningham virus - Revision history

Aidan: /* Clinical Manifestations */

2020-08-14T20:23:05Z

Clinical Manifestations

← Older revision		Revision as of 20:23, 14 August 2020
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	* CNS infection with JC virus, usually in the context of HIV infection		*CNS infection with JC virus, usually in the context of HIV infection

	==Background==		==Background==
	===Epidemiology===		===Epidemiology===

	* HIV patients		*HIV patients

	==Clinical Manifestations==		==Clinical Manifestations==

⚫	* '''~~Classic~~ PML'''
			*'''Classic progressive multifocal leukoencephalopathy (PML)'''
	** Subacute onset of focal central neurological lesions		**Subacute onset of focal central neurological lesions
	** Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI		**Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI
	* '''PML-IRIS'''
		⚫	*'''PML-IRIS'''
	** Focal central neurological lesions following immune recovery		**Focal central neurological lesions following immune recovery
	** Contrast enhancing lesions with or without mass effect on MRI		**Contrast enhancing lesions with or without mass effect on MRI
	* '''JCV granule cell neuropathy'''		*'''JCV granule cell neuropathy'''
	** Chronic cerebellar dysfunction		**Chronic cerebellar dysfunction
	** Cerebellar atrophy on MRI		**Cerebellar atrophy on MRI
	* '''JCV encephalitis'''		*'''JCV encephalitis'''
	** Subacute onset of encephalopathy		**Subacute onset of encephalopathy
	** Cortical lesions on MRI		**Cortical lesions on MRI
	* '''JCV meningitis'''		*'''JCV meningitis'''
	** Chronic headaches		**Chronic headaches
	** Ventriculomegaly on MRI		**Ventriculomegaly on MRI

	==Investigations==		==Investigations==

	* MRI head: white matter changes		*MRI head: white matter changes
	* CSF: fairly nonspecific, with mild pleocytosis, slightly elevated protein, and normal glucose		*CSF: fairly nonspecific, with mild pleocytosis, slightly elevated protein, and normal glucose
	** PCR of CSF has sensitivity 58% with ART or 72-92% without, and specificity 92-100%		**PCR of CSF has sensitivity 58% with ART or 72-92% without, and specificity 92-100%

	==Diagnosis==		==Diagnosis==

	* JC virus PCR of CSF or brain biopsy		*JC virus PCR of CSF or brain biopsy

	==Treatment==		==Treatment==

	* Antiretroviral therapy for HIV		*Antiretroviral therapy for HIV

	[[Category:HIV]]		[[Category:HIV]]

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-14T23:13:20Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 23:13, 14 July 2020
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	* HIV patients		* HIV patients

	==Clinical ~~Presentation~~==		==Clinical Manifestations==
	* '''Classic PML'''		* '''Classic PML'''
	** Subacute onset of focal central neurological lesions		** Subacute onset of focal central neurological lesions

Aidan: /* Diagnosis */

2020-05-23T18:56:42Z

Diagnosis

← Older revision		Revision as of 18:56, 23 May 2020
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	==Diagnosis==		==Diagnosis==
	* JC virus PCR		* JC virus PCR of CSF or brain biopsy

	==Treatment==		==Treatment==

Aidan: /* Investigations */ added CSF

2020-05-23T18:56:10Z

Investigations: added CSF

← Older revision		Revision as of 18:56, 23 May 2020
Line 24:		Line 24:
	==Investigations==		==Investigations==
	* MRI head: white matter changes		* MRI head: white matter changes
			* CSF: fairly nonspecific, with mild pleocytosis, slightly elevated protein, and normal glucose
			** PCR of CSF has sensitivity 58% with ART or 72-92% without, and specificity 92-100%

	==Diagnosis==		==Diagnosis==

Aidan: added Clinical Presentation

2020-05-23T18:50:34Z

added Clinical Presentation

← Older revision		Revision as of 18:50, 23 May 2020
Line 1:		Line 1:
	* CNS infection with JC virus, usually in the context of HIV infection		* CNS infection with JC virus, usually in the context of HIV infection

	== ~~Epidemiology~~ ==		==Background==
			===Epidemiology===

	* HIV patients		* HIV patients

			==Clinical Presentation==
⚫	== Investigations ==
			* '''Classic PML'''
			** Subacute onset of focal central neurological lesions
			** Asymmetric, well-demarcated, nonenchancing subcortical white matter lesions on MRI
			* '''PML-IRIS'''
			** Focal central neurological lesions following immune recovery
			** Contrast enhancing lesions with or without mass effect on MRI
			* '''JCV granule cell neuropathy'''
			** Chronic cerebellar dysfunction
			** Cerebellar atrophy on MRI
			* '''JCV encephalitis'''
			** Subacute onset of encephalopathy
			** Cortical lesions on MRI
			* '''JCV meningitis'''
			** Chronic headaches
			** Ventriculomegaly on MRI

		⚫	==Investigations==
	* MRI head: white matter changes		* MRI head: white matter changes

	== Diagnosis ==		==Diagnosis==

	* JC virus PCR		* JC virus PCR

	== Treatment ==		==Treatment==

	* Antiretroviral therapy for HIV		* Antiretroviral therapy for HIV

Aidan at 20:17, 15 August 2019

2019-08-15T20:17:42Z

← Older revision		Revision as of 20:17, 15 August 2019
Line 1:		Line 1:
	* CNS infection with JC virus, usually in the context of HIV infection		* CNS infection with JC virus, usually in the context of HIV infection

	= Epidemiology =		== Epidemiology ==

	* HIV patients		* HIV patients

	= Investigations =		== Investigations ==

	* MRI head: white matter changes		* MRI head: white matter changes

	= Diagnosis =		== Diagnosis ==

	* JC virus PCR		* JC virus PCR

	= Treatment =		== Treatment ==

	* Antiretroviral therapy for HIV		* Antiretroviral therapy for HIV

Aidan at 00:01, 15 August 2019

2019-08-15T00:01:45Z

← Older revision		Revision as of 00:01, 15 August 2019
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	[[Category:HIV]]		[[Category:HIV]]
	[[Category:~~Papillomaviridae~~]]		[[Category:Polyomaviridae]]

Aidan at 00:01, 15 August 2019

2019-08-15T00:01:04Z

← Older revision		Revision as of 00:01, 15 August 2019
Line 1:		Line 1:
	= Progressive multifocal leukoencephalopathy (PML) =

	== Etiology ==

	* CNS infection with JC virus, usually in the context of HIV infection		* CNS infection with JC virus, usually in the context of HIV infection

	== Epidemiology ==		= Epidemiology =

	* HIV patients		* HIV patients

	== Investigations ==		= Investigations =

	* MRI head: white matter changes		* MRI head: white matter changes

	== Diagnosis ==		= Diagnosis =

	* JC virus PCR		* JC virus PCR

	== Treatment ==		= Treatment =

	* Antiretroviral therapy for HIV		* Antiretroviral therapy for HIV

			[[Category:HIV]]
			[[Category:Papillomaviridae]]

Aidan: Aidan moved page DNA Progressive multifocal leukoencephalopathy (PML) to John Cunningham virus without leaving a redirect

2019-08-14T23:59:37Z

Aidan moved page DNA Progressive multifocal leukoencephalopathy (PML) to John Cunningham virus without leaving a redirect

← Older revision		Revision as of 23:59, 14 August 2019
(No difference)

Maintenance script: Imported from text file

2019-08-11T18:05:51Z

Imported from text file

New page

= Progressive multifocal leukoencephalopathy (PML) =

== Etiology ==

* CNS infection with JC virus, usually in the context of HIV infection

== Epidemiology ==

* HIV patients

== Investigations ==

* MRI head: white matter changes

== Diagnosis ==

* JC virus PCR

== Treatment ==

* Antiretroviral therapy for HIV