https://idwiki.org/index.php?action=history&feed=atom&title=Intrahepatic_cholestasis_of_pregnancy 2026-05-13T01:00:12Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Intrahepatic_cholestasis_of_pregnancy&diff=5016&oldid=prev 2020-07-17T13:39:43Z

<p>Text replacement - &quot;Clinical Presentation&quot; to &quot;Clinical Manifestations&quot;</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:39, 17 July 2020</td> </tr><tr> <td colspan="2" class="diff-lineno">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td> </tr> <tr> <td class="diff-marker" data-marker="−"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <del style="font-weight: bold; text-decoration: none;">Presentation</del> ==</div></td> <td class="diff-marker" data-marker="+"></td> <td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Clinical <ins style="font-weight: bold; text-decoration: none;">Manifestations</ins> ==</div></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br /></td> </tr> <tr> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Pruritus, especially of palms and soles, '''without''' rash</div></td> <td class="diff-marker"></td> <td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Pruritus, especially of palms and soles, '''without''' rash</div></td> </tr> <!-- diff cache key site7_mediawiki:diff:1.41:old-4292:rev-5016:wikidiff2=table:1.13.0:bc2a06be --> </table>

Aidan https://idwiki.org/index.php?title=Intrahepatic_cholestasis_of_pregnancy&diff=4292&oldid=prev 2020-07-04T01:17:41Z

<p>Imported from text file</p> <p><b>New page</b></p><div>== Clinical Presentation ==<br /> <br /> * Pruritus, especially of palms and soles, &#039;&#039;&#039;without&#039;&#039;&#039; rash<br /> * Typically occurs in second half of pregnancy<br /> * Liver is not tender<br /> * Usually has a family history<br /> * More common in Sweden and Chile<br /> <br /> == Differential Diagnosis ==<br /> <br /> * Pemphidois gestationis: typically has a rash<br /> * Pruritic urticarial papules of pregnancy (PUPP): has urticaria<br /> <br /> == Diagnosis ==<br /> <br /> * Exclude other causes<br /> * Abdominal ultrasuond should be normal<br /> * Liver panel may show elevated AST/ALT (can be &#039;&#039;&#039;very&#039;&#039;&#039; high), but should have normal bilirubin and GGT<br /> * Fasting bile acids &amp;gt; 10 for diagnosis, but takes up to 5 days<br /> <br /> == Management ==<br /> <br /> * Ursodeoxycholic acid 10-15 mg/kg/day<br /> ** Typical dose 250-500 mg po BID<br /> ** Takes a few days to have an effect<br /> * Can also trial antihistamines, benzodiazepines, vitamin K, and topical creams<br /> * Cholestyramine is &#039;&#039;&#039;not&#039;&#039;&#039; helpful<br /> * Try to deliver around 38 weeks, given low (but real) risk of complications<br /> <br /> == Prognosis and Complications ==<br /> <br /> * Complications are proportional to the level of bile acids<br /> * Stillbirth in less than 1%<br /> * Prematurity<br /> * Meconium aspiration<br /> <br /> [[Category:Gastroenterology]]<br /> [[Category:Obstetrical medicine]]</div>

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