Interstitial nephritis - Revision history

Aidan at 20:01, 2 August 2020

2020-08-02T20:01:10Z

← Older revision		Revision as of 20:01, 2 August 2020
Line 1:		Line 1:
	== Etiology ==		==Etiology==

	=== Drugs ===		===Drugs===

	* Nonsteroidal antiinflammatory agents (NSAIDs)		*Nonsteroidal antiinflammatory agents (NSAIDs)
	** Includes selective cyclooxygenase (COX)-2 inhibitors and mesalamine		**Includes selective cyclooxygenase (COX)-2 inhibitors and [[mesalamine]]
	* Antimicrobials		*Antimicrobials
	** Penicillins and cephalosporins		**[[Penicillin\|Penicillins]] and [[Cephalosporin\|cephalosporins]]
	** Rifampin		**[[Rifampin]]
	** Trimethoprim-sulfamethoxazole		**[[Trimethoprim-sulfamethoxazole]]
	** Ciprofloxacin		**[[Ciprofloxacin]]
	** Indinavir		**[[Indinavir]]
	* Diuretics, including furosemide and thiazides		*Diuretics, including [[furosemide]] and [[Thiazide\|thiazides]]
	* Cimetidine		*[[Cimetidine]]
	* Allopurinol		*[[Allopurinol]]
	* Proton pump inhibitors (PPIs)		*[[Proton pump inhibitor\|Proton pump inhibitors]] (PPIs)

	=== Infections ===		===Infections===

	Long list, including ''Legionella'', ''Leptospira'', cytomegalovirus ~~(CMV)~~, ~~''Streptococcus''~~, ''Mycobacterium tuberculosis'', ''Corynebacterium diphtheriae'', Epstein-Barr virus ~~(EBV)~~, ''Yersinia'', polyomavirus, ''Enterococcus'', ''Escherichia coli'', adenovirus, and ''Candida''.		* Long list, including ''[[Legionella]]'', ''[[Leptospira]]'', [[cytomegalovirus]], [[streptococci]], ''[[Mycobacterium tuberculosis]]'', ''[[Corynebacterium diphtheriae]]'', [[Epstein-Barr virus]], ''[[Yersinia]]'', [[polyomavirus]], ''[[Enterococcus]]'', ''[[Escherichia coli]]'', [[adenovirus]], and ''[[Candida]]''

	=== Autoimmune Disorders ===		===Autoimmune Disorders===

	* Systemic lupus erythematosus		*[[Systemic lupus erythematosus]]
	* Sarcoidosis		*[[Sarcoidosis]]
	* Sjögren syndrome		*[[Sjögren syndrome]]
	* IgG4 disease		*[[IgG4 disease]]

	== Clinical Manifestations ==		==Clinical Manifestations==

	* Can be asymptomatic, presenting with renal dysfunction		*Can be asymptomatic, presenting with renal dysfunction
	* Nausea, vomiting, malaise, and oliguria		*Nausea, vomiting, malaise, and oliguria
	* May have arthralgias		*May have arthralgias
	* With drug-induced AIN, can have an allergic syndrome that includes fever, eosinophilia, and rash		*With drug-induced AIN, can have an allergic syndrome that includes fever, eosinophilia, and rash

	== Investigations ==		==Investigations==

	* Creatinine, showing AKI		*Creatinine, showing AKI
	* CBC, showing eosinophilia		*CBC, showing eosinophilia
	* Urine studies		*Urine studies
	** May have pyuria and white cell casts and RBCs, and eosinophiluria		**May have pyuria and white cell casts and RBCs, and eosinophiluria
	** Usually around 1 g/day of proteinuria		**Usually around 1 g/day of proteinuria
	** FENa >1%		**FENa >1%

	[[Category:Nephrology]]		[[Category:Nephrology]]

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-14T23:22:12Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 23:22, 14 July 2020
Line 27:		Line 27:
	* IgG4 disease		* IgG4 disease

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==

	* Can be asymptomatic, presenting with renal dysfunction		* Can be asymptomatic, presenting with renal dysfunction

Maintenance script: Imported from text file

2020-07-04T01:17:41Z

Imported from text file

New page

== Etiology ==

=== Drugs ===

* Nonsteroidal antiinflammatory agents (NSAIDs)
** Includes selective cyclooxygenase (COX)-2 inhibitors and mesalamine
* Antimicrobials
** Penicillins and cephalosporins
** Rifampin
** Trimethoprim-sulfamethoxazole
** Ciprofloxacin
** Indinavir
* Diuretics, including furosemide and thiazides
* Cimetidine
* Allopurinol
* Proton pump inhibitors (PPIs)

=== Infections ===

Long list, including ''Legionella'', ''Leptospira'', cytomegalovirus (CMV), ''Streptococcus'', ''Mycobacterium tuberculosis'', ''Corynebacterium diphtheriae'', Epstein-Barr virus (EBV), ''Yersinia'', polyomavirus, ''Enterococcus'', ''Escherichia coli'', adenovirus, and ''Candida''.

=== Autoimmune Disorders ===

* Systemic lupus erythematosus
* Sarcoidosis
* Sjögren syndrome
* IgG4 disease

== Clinical Presentation ==

* Can be asymptomatic, presenting with renal dysfunction
* Nausea, vomiting, malaise, and oliguria
* May have arthralgias
* With drug-induced AIN, can have an allergic syndrome that includes fever, eosinophilia, and rash

== Investigations ==

* Creatinine, showing AKI
* CBC, showing eosinophilia
* Urine studies
** May have pyuria and white cell casts and RBCs, and eosinophiluria
** Usually around 1 g/day of proteinuria
** FENa >1%

[[Category:Nephrology]]