Infections in solid-organ transplantation - Revision history

Aidan: linkified

2020-08-06T21:38:53Z

linkified

← Older revision		Revision as of 21:38, 6 August 2020
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	== Pretransplant Screening ==		==Pretransplant Screening==

	=== Donor screen ===		===Donor screen===

	* Bacterial: syphilis, urine and blood cultures, bronchoalveolar lavage		*Bacterial: [[syphilis]], urine and blood cultures, bronchoalveolar lavage
	* Viral: CMV, EBV, HIV HBV, HCV, HSV, VZV, HTLV-1		*Viral: [[CMV after solid organ transplantation\|CMV]], [[EBV]], [[HIV]], [[HBV]], [[HCV]], [[HSV]], [[VZV]], [[HTLV-1]]
	* Other: Strongyloides, Chagas (sometimes)		*Other: [[Strongyloides stercoralis]], [[Chagas disease]] (sometimes)

	=== Recipient Screen ===		===Recipient Screen===

	* Prednisone: TB/HBV/~~Strongy~~		*[[Prednisone]]: [[TB]]/[[HBV]]/[[Strongyloides]]
	* Fludarabine:		*[[Fludarabine]]:
	** Lasts 6-12 months after last dose		**Lasts 6-12 months after last dose
	** Listeria, PCP, and Nocardia		**Listeria, PCP, and Nocardia
	* Rituximab: as well as B-cell, can allow HBV and PJP infections		*[[Rituximab]]: as well as B-cell, can allow [[HBV]] and [[PJP]] infections
	* Adalimumab: T-cell deficiency for months after last dose		*[[Adalimumab]]: T-cell deficiency for months after last dose
	* TNF-~~alpha~~ inhibitors: ~~like~~ prednisone		*[[TNF-α inhibitors]]: similar to [[prednisone]]

	== Post-Transplant Infections ==		==Post-Transplant Infections==

	=== Early Infections (≤30 days) ===		===Early Infections (≤30 days)===

	* T-cell deficit ~~greater~~ than B-cell		*Major risk factor is T-cell deficit, more than than B-cell deficit
		⚫	*Surgical site infection
		⚫	**Bacterial
		⚫	**Fungal: [[Aspergillus]] and [[Mucorales]]
			*Organ-specific
			**Cardiac
		⚫	***LVAD infection
		⚫	***[[Non-tuberculous mycobacteria\|Mycobacterial infection]] (very late)
			**Lungs
			***Donor-derived [[Ventilator-associated pneumonia\|VAP]]
			***Anastomotic infection, including fungal
			**Liver: anastamotic leak, including [[VRE]] peritonitis
			*Hospital-acquired: [[Central line-associated bloodstream infection\|central line infections]] and resistant organisms
			*Donor-derived bacterial infections, including [[syphilis]]

		⚫	===Late Infections (30 days to 3-6 months)===
⚫	* Surgical site infection
⚫	** Bacterial
⚫	** Fungal: Aspergillus and ~~Mucor Organ-specific Cardiac~~
⚫	* LVAD infection
⚫	* Mycobacterial infection (very late) ~~Lungs~~
	* Donor-derived VAP
	* Anastomotic infection, including fungal Liver: anastamotic leak, including VRE peritonitis Hospital-acquired: central line infections and resistant organisms Donor-derived bacterial infections, including syphilis

		⚫	*Major risk factor is T-cell deficit, more than B-cell deficit
⚫	=== Late Infections (30 days to 3-6 months) ===
		⚫	*Occur as your withdraw prophylactic antimicrobials
		⚫	*Reactivation infections
			**[[EBV]]/[[CMV after solid organ transplantation\|CMV]]/[[HSV]]/[[VZV]]
			**[[TB]], [[PCP]], [[Invasive fungal infection\|invasive fungal infections]]

		⚫	===Very Late Infections (>6 months)===
⚫	* T-cell deficit ~~greater~~ than B-cell

		⚫	*B-cell deficits and variable T-cell deficits
⚫	* Reactivation infections
		⚫	*Usually regular community-acquired infections, but more severe
	* EBV/CMV/HSV/VZV
⚫	* ~~TB, PCP, invasive fungal infections~~ Occur as your withdraw prophylactic antimicrobials

⚫	=== Very Late Infections (>6 months) ===

⚫	* B-cell deficits and variable T-cell deficits
⚫	* Usually regular community-acquired infections, but more severe

	[[Category:Transplant patients]]		[[Category:Transplant patients]]

Aidan: Aidan moved page Solid-organ transplant infections to Infections in solid-organ transplantation

2020-08-06T21:32:58Z

Aidan moved page Solid-organ transplant infections to Infections in solid-organ transplantation

← Older revision	Revision as of 21:32, 6 August 2020
(No difference)

Aidan at 19:44, 15 August 2019

2019-08-15T19:44:04Z

← Older revision		Revision as of 19:44, 15 August 2019
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			== Pretransplant Screening ==
⚫	= Donor screen =

		⚫	=== Donor screen ===

	* Bacterial: syphilis, urine and blood cultures, bronchoalveolar lavage		* Bacterial: syphilis, urine and blood cultures, bronchoalveolar lavage
Line 5:		Line 7:
	* Other: Strongyloides, Chagas (sometimes)		* Other: Strongyloides, Chagas (sometimes)

	= Recipient Screen =		=== Recipient Screen ===

	* Prednisone: TB/HBV/Strongy		* Prednisone: TB/HBV/Strongy
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	* TNF-alpha inhibitors: like prednisone		* TNF-alpha inhibitors: like prednisone

	= ~~Early~~ Infections =		== Post-Transplant Infections ==

			=== Early Infections (≤30 days) ===

	* ≤30 days
	* T-cell deficit greater than B-cell		* T-cell deficit greater than B-cell

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	* Anastomotic infection, including fungal Liver: anastamotic leak, including VRE peritonitis Hospital-acquired: central line infections and resistant organisms Donor-derived bacterial infections, including syphilis		* Anastomotic infection, including fungal Liver: anastamotic leak, including VRE peritonitis Hospital-acquired: central line infections and resistant organisms Donor-derived bacterial infections, including syphilis

	= Late Infections =		=== Late Infections (30 days to 3-6 months) ===

	* 30 days to 3-6 months
	* T-cell deficit greater than B-cell		* T-cell deficit greater than B-cell

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	* TB, PCP, invasive fungal infections Occur as your withdraw prophylactic antimicrobials		* TB, PCP, invasive fungal infections Occur as your withdraw prophylactic antimicrobials

	= Very Late Infections =		=== Very Late Infections (>6 months) ===

	* More than 6 months
	* B-cell deficits and variable T-cell deficits		* B-cell deficits and variable T-cell deficits
	* Usually regular community-acquired infections, but more severe		* Usually regular community-acquired infections, but more severe

Aidan at 22:52, 14 August 2019

2019-08-14T22:52:41Z

← Older revision		Revision as of 22:52, 14 August 2019
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		⚫	= Donor screen =
	= Infections in solid-organ transplantation =

⚫	== Donor screen ==

	* Bacterial: syphilis, urine and blood cultures, bronchoalveolar lavage		* Bacterial: syphilis, urine and blood cultures, bronchoalveolar lavage
Line 7:		Line 5:
	* Other: Strongyloides, Chagas (sometimes)		* Other: Strongyloides, Chagas (sometimes)

	== Recipient ~~screen~~ ==		= Recipient Screen =

	Prednisone: TB/HBV/Strongy ~~Fludarabine:~~		* Prednisone: TB/HBV/Strongy
			* Fludarabine:
		⚫	** Lasts 6-12 months after last dose
			** Listeria, PCP, and Nocardia
			* Rituximab: as well as B-cell, can allow HBV and PJP infections
			* Adalimumab: T-cell deficiency for months after last dose
			* TNF-alpha inhibitors: like prednisone

		⚫	= Early Infections =
⚫	* Lasts 6-12 months after last dose
	* Listeria, PCP, and Nocardia Rituximab: as well as B-cell, can allow HBV and PJP infections Adalimumab: T-cell deficiency for months after last dose TNF-alpha inhibitors: like prednisone

			* ≤30 days
⚫	== Early ==
			* T-cell deficit greater than B-cell

⚫	~~≤30 days T-cell deficit greater than B-cell Surgical site infection Bacterial~~ Fungal: Aspergillus and Mucor Organ-specific Cardiac

			* Surgical site infection
			** Bacterial
		⚫	** Fungal: Aspergillus and Mucor Organ-specific Cardiac
	* LVAD infection		* LVAD infection
	* Mycobacterial infection (very late) Lungs		* Mycobacterial infection (very late) Lungs
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	* Anastomotic infection, including fungal Liver: anastamotic leak, including VRE peritonitis Hospital-acquired: central line infections and resistant organisms Donor-derived bacterial infections, including syphilis		* Anastomotic infection, including fungal Liver: anastamotic leak, including VRE peritonitis Hospital-acquired: central line infections and resistant organisms Donor-derived bacterial infections, including syphilis

	== Late ==		= Late Infections =

	30 days to 3-6 months ~~T-cell deficit greater than B-cell Reactivation infections~~		* 30 days to 3-6 months
			* T-cell deficit greater than B-cell

			* Reactivation infections
	* EBV/CMV/HSV/VZV		* EBV/CMV/HSV/VZV
	* TB, PCP, invasive fungal infections Occur as your withdraw prophylactic antimicrobials		* TB, PCP, invasive fungal infections Occur as your withdraw prophylactic antimicrobials

	== Very ~~late~~ ==		= Very Late Infections =

	* More than 6 months		* More than 6 months
	* B-cell deficits and variable T-cell deficits		* B-cell deficits and variable T-cell deficits
	* Usually regular community-acquired infections, but more severe		* Usually regular community-acquired infections, but more severe

			[[Category:Transplant patients]]

Aidan: Aidan moved page Special Immune Solid-organ transplant infections to Solid-organ transplant infections without leaving a redirect

2019-08-14T22:49:37Z

Aidan moved page Special Immune Solid-organ transplant infections to Solid-organ transplant infections without leaving a redirect

← Older revision	Revision as of 22:49, 14 August 2019
(No difference)

Maintenance script: Imported from text file

2019-08-11T18:05:59Z

Imported from text file

New page

= Infections in solid-organ transplantation =

== Donor screen ==

* Bacterial: syphilis, urine and blood cultures, bronchoalveolar lavage
* Viral: CMV, EBV, HIV HBV, HCV, HSV, VZV, HTLV-1
* Other: Strongyloides, Chagas (sometimes)

== Recipient screen ==

Prednisone: TB/HBV/Strongy Fludarabine:

* Lasts 6-12 months after last dose
* Listeria, PCP, and Nocardia Rituximab: as well as B-cell, can allow HBV and PJP infections Adalimumab: T-cell deficiency for months after last dose TNF-alpha inhibitors: like prednisone

== Early ==

≤30 days T-cell deficit greater than B-cell Surgical site infection Bacterial Fungal: Aspergillus and Mucor Organ-specific Cardiac

* LVAD infection
* Mycobacterial infection (very late) Lungs
* Donor-derived VAP
* Anastomotic infection, including fungal Liver: anastamotic leak, including VRE peritonitis Hospital-acquired: central line infections and resistant organisms Donor-derived bacterial infections, including syphilis

== Late ==

30 days to 3-6 months T-cell deficit greater than B-cell Reactivation infections

* EBV/CMV/HSV/VZV
* TB, PCP, invasive fungal infections Occur as your withdraw prophylactic antimicrobials

== Very late ==

* More than 6 months
* B-cell deficits and variable T-cell deficits
* Usually regular community-acquired infections, but more severe