https://idwiki.org/index.php?action=history&feed=atom&title=Immune_effector_cell-associated_neurotoxicity_syndrome 2026-04-28T21:00:10Z Revision history for this page on the wiki MediaWiki 1.43.8 https://idwiki.org/index.php?title=Immune_effector_cell-associated_neurotoxicity_syndrome&diff=10462&oldid=prev 2024-03-26T01:59:41Z

<p>Created page with &quot;== Background == * Adverse effect of <a href="/CAR-T" class="mw-redirect" title="CAR-T">CAR-T</a> and <a href="/BiTE" class="mw-redirect" title="BiTE">BiTE</a> therapies == Clinical Manifestations == * Encephalopathy, delirium, confusion, disorientation * Seizures * Aphasia or dysphasia * Tremor, ataxia * Dyscalculia * Headache == ASTCT ICANS Grading<a href="/index.php?title=CiteRef::lee2019as&amp;action=edit&amp;redlink=1" class="new" title="CiteRef::lee2019as (page does not exist)">CiteRef::lee2019as</a> == {| class=&quot;wikitable&quot; !Domain !Grade 1 !Grade 2 !Grade 3 !Grade 4 |- |ICE score |7-9 |3-6 |0-2 |Unarousable |- |Level of consciousness |Awakens spontaneously |Awakens to voice |Awakens to tactil...&quot;</p> <p><b>New page</b></p><div>== Background ==<br /> <br /> * Adverse effect of [[CAR-T]] and [[BiTE]] therapies<br /> <br /> == Clinical Manifestations ==<br /> <br /> * Encephalopathy, delirium, confusion, disorientation<br /> * Seizures<br /> * Aphasia or dysphasia<br /> * Tremor, ataxia<br /> * Dyscalculia<br /> * Headache<br /> <br /> == ASTCT ICANS Grading[[CiteRef::lee2019as]] ==<br /> {| class=&quot;wikitable&quot;<br /> !Domain<br /> !Grade 1<br /> !Grade 2<br /> !Grade 3<br /> !Grade 4<br /> |-<br /> |ICE score<br /> |7-9<br /> |3-6<br /> |0-2<br /> |Unarousable<br /> |-<br /> |Level of consciousness<br /> |Awakens spontaneously<br /> |Awakens to voice<br /> |Awakens to tactile stimulus<br /> |Unarousable, stupor, coma, or requires vigorous or repetitive tactile stimuli<br /> |-<br /> |Seizure<br /> |—<br /> |—<br /> |Any that resolves rapidly, or nonconvulsive seizure on EEG that resolves with intervention<br /> |Life-threatening seizure &gt;5 min or [[status epilepticus]]<br /> |-<br /> |Motor findings<br /> |—<br /> |—<br /> |—<br /> |Deep focal motor weakness, such as hemiparesis or paraparesis<br /> |-<br /> |ICP/cerebral edema<br /> |—<br /> |—<br /> |Focal or local edema on neuroimaging<br /> |Diffuse cerebral edema on neuroimaging; decerebrate or decorticate posturing;[[cranial nerve VI palsy]]; [[papilledema]]; or [[Cushing triad]]<br /> |}<br /> <br /> === ICE Assessment Tool ===<br /> {| class=&quot;wikitable&quot;<br /> !Domain<br /> !Description<br /> !Points<br /> |-<br /> |Orientation<br /> |orientation to year, month, city, and hospital<br /> |4<br /> |-<br /> |Naming<br /> |ability to name 3 objects (e.g. point to clock, pen, button)<br /> |3<br /> |-<br /> |Following commands<br /> |ability to follow simple commands (e.g. &quot;Show me 2 fingers&quot;, &quot;Close you eyes and stick out your tongue&quot;<br /> |1<br /> |-<br /> |Writing<br /> |ability to write a standard sentence (e.g. &quot;Our national bird is the bald eagle&quot;)<br /> |1<br /> |-<br /> |Attention<br /> |ability to count backwards from 100 by 10<br /> |1<br /> |}<br /> <br /> == Management ==<br /> <br /> * High-dose steroids, depending on grading<br /> <br /> [[Category:Hematology]]<br /> [[Category:Oncology]]<br /> [[Category:Neurology]]<br /> [[Category:Adverse drug reactions]]</div>

Aidan