Aidan: Created page with "== Background == * A collection of primary immunodeficiencies characterized by normal total IgG but decrease in one or more subclasses of IgG {| class="wikitable" !Subclass !Proportion of Total IgGCiteRef::vidarsson2014ig |- |IgG1 |60% |- |IgG2 |32% |- |IgG3 |4% |- |IgG4 |4% |} == Clinical Manifestations == * The majority of people who have IgG subtype deficiency are asymptomatic * Symptoms could include recurrent URTI (most common),..."

2026-01-14T18:40:17Z

Created page with "== Background == * A collection of primary immunodeficiencies characterized by normal total IgG but decrease in one or more subclasses of IgG {| class="wikitable" !Subclass !Proportion of Total IgGCiteRef::vidarsson2014ig |- |IgG1 |60% |- |IgG2 |32% |- |IgG3 |4% |- |IgG4 |4% |} == Clinical Manifestations == * The majority of people who have IgG subtype deficiency are asymptomatic * Symptoms could include recurrent URTI (most common),..."

New page

== Background ==

* A collection of [[Primary immunodeficiency|primary immunodeficiencies]] characterized by normal total IgG but decrease in one or more subclasses of IgG

{| class="wikitable"
!Subclass
!Proportion of Total IgG[[CiteRef::vidarsson2014ig]]
|-
|IgG1
|60%
|-
|IgG2
|32%
|-
|IgG3
|4%
|-
|IgG4
|4%
|}

== Clinical Manifestations ==

* The majority of people who have IgG subtype deficiency are asymptomatic
* Symptoms could include recurrent URTI (most common), recurrent pneumonias (more with IgG2+4), recurrent GI infection (more IgG1, IgG2+4, and IgG3+4), bronchiectasis (particularly IgG2+4 and IgG3+4), recurrent HSV (more IgG3 and IgG4 and IgG3+4), and recurrent VZV (most notably IgG3)[[CiteRef::dogru2025re]]
* Associated with autoimmunity in general (may be a symptoms rather than cause)
* May be associated with atopic disease, ataxia-telangiectasia, vasculitis, and [[IBD]] (particularly IgG4 deficiency)
** Inflammatory arthritis most notable with IgG1+3
** Thyroid disorders
* May be associated with [[asthma]] and [[COPD]], particularly IgG1 and IgG2 deficiencies

{| class="wikitable"
!Subclass Deficiency[[CiteRef::dogru2025re]]
!Infections
!Immune Dysregulation
|-
|IgG1
|
|
|-
|IgG2
|
|
|-
|IgG3
|VZV
|
|-
|IgG4
|
|
|-
|IgG1+3
|
|inflammatory arthritis
|-
|IgG2+4
|pneumonia, bronchiectasis
|splenomegaly
|-
|IgG3+4
|
|
|}
[[Category:Primary immunodeficiencies]]

IgG subclass deficiency - Revision history