Human granulocytotropic anaplasmosis - Revision history

Aidan: Redirected page to Anaplasma phagocytophilum

2019-08-13T17:42:09Z

Redirected page to Anaplasma phagocytophilum

← Older revision		Revision as of 17:42, 13 August 2019
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	* ~~Infection caused by ''~~[[Anaplasma phagocytophilum]]''		#REDIRECT [[Anaplasma phagocytophilum]]

	= Clinical Presentation =

	* Incubation period of 1 to 2 weeks
	* Usually an acute undifferentiated fever
	* Can be mild or severe
	* Fever, headache, malaise, and myalgias are common
	* Can also cause nausea, vomiting, diarrhea, cough, arthralgias, nuchal rigidity, and confusion
	* Less than 10% have rash, most of which is concurrent Lyme disease
	* 36% of cases require hospitalization, and it is severe in 3 to 7%
	* Severe complications include respiratory failure, septic shock, rhabdomyolysis, hemorrhage, and opportunistic infections
	** Rare meningoencephalitis
	* Higher case-fatality rate in Shandong Province in China, for no clear reason (16% versus 2.6%)
	* Thrombocytopenia, lerkopenia, and mild anemia are common
	** Return to normal range within 14 days, but with persistent left shift
	* Abnormal liver enzymes are common in the first 7 days

	= Diagnosis =

	* 20-80% of patients will have circulating neutrophils with detectable '''morulae''' on blood film (in neutrophils/granulocytes)
	* Serology used to diagnose, by measuring IgG levels ≥1:64 or a fourfold rise
	** IgM testing less sensitive and specific
	* Culture not done routinely
	* PCR possible

	= Management =

	* Doxycycline 100 mg po bid

Aidan: Split species away from disease

2019-08-13T17:23:28Z

Split species away from disease

← Older revision		Revision as of 17:23, 13 August 2019
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	= ~~Human~~ ~~granulocytotropic~~ ~~anaplasmosis~~ (''Anaplasma phagocytophilum''~~) =~~		* Infection caused by ''[[Anaplasma phagocytophilum]]''

		⚫	= Clinical Presentation =
	== Microbiology ==

	* Small, obligate intracellular Gram-negative bacterium
	* Related to Ehrlichia and Rickettsiae
	* Tropism for neutrophils

⚫	== Clinical Presentation ==

	* Incubation period of 1 to 2 weeks		* Incubation period of 1 to 2 weeks
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	* Abnormal liver enzymes are common in the first 7 days		* Abnormal liver enzymes are common in the first 7 days

	== Diagnosis ==		= Diagnosis =

	* 20-80% of patients will have circulating neutrophils with detectable '''morulae''' on blood film (in neutrophils/granulocytes)		* 20-80% of patients will have circulating neutrophils with detectable '''morulae''' on blood film (in neutrophils/granulocytes)
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	* PCR possible		* PCR possible

	== Management ==		= Management =

	* Doxycycline 100 mg po bid		* Doxycycline 100 mg po bid

Aidan: Aidan moved page Anaplasmosis (A. phagocytophilum) to Human granulocytotropic anaplasmosis without leaving a redirect

2019-08-13T17:21:02Z

Aidan moved page Anaplasmosis (A. phagocytophilum) to Human granulocytotropic anaplasmosis without leaving a redirect

← Older revision	Revision as of 17:21, 13 August 2019
(No difference)

Maintenance script: Imported from text file

2019-08-11T18:05:47Z

Imported from text file

New page

= Human granulocytotropic anaplasmosis (''Anaplasma phagocytophilum'') =

== Microbiology ==

* Small, obligate intracellular Gram-negative bacterium
* Related to Ehrlichia and Rickettsiae
* Tropism for neutrophils

== Clinical Presentation ==

* Incubation period of 1 to 2 weeks
* Usually an acute undifferentiated fever
* Can be mild or severe
* Fever, headache, malaise, and myalgias are common
* Can also cause nausea, vomiting, diarrhea, cough, arthralgias, nuchal rigidity, and confusion
* Less than 10% have rash, most of which is concurrent Lyme disease
* 36% of cases require hospitalization, and it is severe in 3 to 7%
* Severe complications include respiratory failure, septic shock, rhabdomyolysis, hemorrhage, and opportunistic infections
** Rare meningoencephalitis
* Higher case-fatality rate in Shandong Province in China, for no clear reason (16% versus 2.6%)
* Thrombocytopenia, lerkopenia, and mild anemia are common
** Return to normal range within 14 days, but with persistent left shift
* Abnormal liver enzymes are common in the first 7 days

== Diagnosis ==

* 20-80% of patients will have circulating neutrophils with detectable '''morulae''' on blood film (in neutrophils/granulocytes)
* Serology used to diagnose, by measuring IgG levels ≥1:64 or a fourfold rise
** IgM testing less sensitive and specific
* Culture not done routinely
* PCR possible

== Management ==

* Doxycycline 100 mg po bid