Hepatitis E virus - Revision history

Aidan: added more virology info

2022-08-30T13:38:04Z

added more virology info

← Older revision		Revision as of 13:38, 30 August 2022
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* ~~Member~~ of the [[Family::Hepeviridae]] family of RNA viruses		* Refers to viruses in the [[Family::Hepeviridae]] family of RNA viruses
			** Genus [[Genus::Orthohepevirus]], which infects terrestrial mammals and contains species A-D
			*** HEV-A is the main human pathogen
			**** Genotypes 1 and 2 only infect humans
			**** Genotypes 3 and 4 circulate in pigs but can infect humans
			*** HEV-C circulates in rodents and ferrets
			** Genus [[Piscihepevirus]], which infects the cutthroat trout and is not of clinical interest
	* Four genotypes, g1 through g4		* Four genotypes, g1 through g4

	=== Epidemiology ===		=== Epidemiology ===
			* Present globally
	* g1 and g2 are more common in developing countries		* g1 and g2 are more common in developing countries
	** Cause epidemic hepatitis		** Cause epidemic hepatitis
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	** Zoonoses associated with pigs; humans are incidental hosts		** Zoonoses associated with pigs; humans are incidental hosts
	** Most severe infections in pregnant women		** Most severe infections in pregnant women
			* May also be transmitted by transplant or transfusion

	== Clinical Manifestations ==		== Clinical Manifestations ==
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	** [[Cholestasis]] more common in pregnant women		** [[Cholestasis]] more common in pregnant women
	* Liver enzyme abnormalities, over 1000 initially, and [[Causes::hyperbilirubinemia]]		* Liver enzyme abnormalities, over 1000 initially, and [[Causes::hyperbilirubinemia]]
	* ~~Can~~ progress to fulminant hepatitis		* Usually self-limited, but some patients progress to fulminant hepatitis
			* In immunocompromised patients, may lead to chronic infection and [[cirrhosis]]
	* Particularly high mortality rate in pregnant women (25% in third trimester)		* Particularly high mortality rate in pregnant women (25% in third trimester)

Aidan at 12:44, 14 August 2020

2020-08-14T12:44:44Z

← Older revision		Revision as of 12:44, 14 August 2020
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	== Background ==		== Background ==
	=== Microbiology ===		=== Microbiology ===
	* Member of the Hepeviridae family of RNA viruses		* Member of the [[Family::Hepeviridae]] family of RNA viruses
	* ~~Gour~~ genotypes, g1 through g4		* Four genotypes, g1 through g4

	=== Epidemiology ===		=== Epidemiology ===
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	* Particularly high mortality rate in pregnant women (25% in third trimester)		* Particularly high mortality rate in pregnant women (25% in third trimester)

	[[Category:~~RNA viruses~~]]		[[Category:Hepeviridae]]

Aidan: /* Clinical Manifestations */

2020-08-05T13:41:25Z

Clinical Manifestations

← Older revision		Revision as of 13:41, 5 August 2020
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	== Clinical Manifestations ==		== Clinical Manifestations ==
	* Incubation period of about 4 to 6 weeks		* Incubation period of about [[Usual incubation period::4 to 6 weeks]]
	* Flu-like prodrome lasting 1 to 10 days with a low-grade fever, followed by hepatitis		* Flu-like prodrome lasting 1 to 10 days with a low-grade [[Causes::fever]], followed by [[Causes::hepatitis]]
	* May develop pale stools, dark urine, and jaundice		* May develop [[Causes::pale stools]], [[Causes::dark urine]], and [[Causes::jaundice]]
	* Hepatomegaly and sometimes splenomegaly		* [[Causes::Hepatomegaly]] and sometimes [[splenomegaly]]
	** Cholestasis more common in pregnant women		** [[Cholestasis]] more common in pregnant women
	* Liver enzyme abnormalities, over 1000 initially, and hyperbilirubinemia		* Liver enzyme abnormalities, over 1000 initially, and [[Causes::hyperbilirubinemia]]
	* Can progress to fulminant hepatitis		* Can progress to fulminant hepatitis
	* Particularly high mortality rate in pregnant women (25% in third trimester)		* Particularly high mortality rate in pregnant women (25% in third trimester)

Aidan: Text replacement - "Clinical Presentation" to "Clinical Manifestations"

2020-07-14T23:31:18Z

Text replacement - "Clinical Presentation" to "Clinical Manifestations"

← Older revision		Revision as of 23:31, 14 July 2020
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	** Most severe infections in pregnant women		** Most severe infections in pregnant women

	== Clinical ~~Presentation~~ ==		== Clinical Manifestations ==
	* Incubation period of about 4 to 6 weeks		* Incubation period of about 4 to 6 weeks
	* Flu-like prodrome lasting 1 to 10 days with a low-grade fever, followed by hepatitis		* Flu-like prodrome lasting 1 to 10 days with a low-grade fever, followed by hepatitis

Aidan: Initial page creation

2019-11-11T03:18:27Z

Initial page creation

New page

== Background ==
=== Microbiology ===
* Member of the Hepeviridae family of RNA viruses
* Gour genotypes, g1 through g4

=== Epidemiology ===
* g1 and g2 are more common in developing countries
** Cause epidemic hepatitis
** Transmitted fecal-orally
** Associated with contaminated water and poor sanitation
* g3 and g4 more common in the North America and Europe
** Zoonoses associated with pigs; humans are incidental hosts
** Most severe infections in pregnant women

== Clinical Presentation ==
* Incubation period of about 4 to 6 weeks
* Flu-like prodrome lasting 1 to 10 days with a low-grade fever, followed by hepatitis
* May develop pale stools, dark urine, and jaundice
* Hepatomegaly and sometimes splenomegaly
** Cholestasis more common in pregnant women
* Liver enzyme abnormalities, over 1000 initially, and hyperbilirubinemia
* Can progress to fulminant hepatitis
* Particularly high mortality rate in pregnant women (25% in third trimester)

[[Category:RNA viruses]]